Cold storage allows the effective utilization of organs retrieved for transplantation. However, prolonged cold ischemia contributes to organ damage and increases patients’ morbidity and mortality and health care cost. Using recent data from the United Network for Organ Sharing, this paper examines the outcomes of live donor and deceased donor kidney transplants in relation to cold ischemia time.
MouzasG.L.The present status of organ preservation: a review.Postgrad Med J1967; 43: 712–5.
2.
HoffmanA., BergerC., PerskyL.Extracorporeal renal storage.Cleveland (OH): Williams and Wilkins; 1965.
3.
CollinsG.M., Bravo-ShugarmanM., TerasakiP.I.Kidney preservation for transportation. Initial perfusion and 30 hours’ ice storage.Lancet1969; ii: 1219–22.
4.
SouthardJ.H., van GulikT.M., AmetaniM.S.Important components of the UW solution.Transplantation1990; 49: 251–7.
5.
BelzerF.O., D'AlessandroA.M., HoffmannR.M.The use of UW solution in clinical transplantation. A 4-year experience.Ann Surg1992; 215: 579–83: discussion 584–5.
6.
OjoA.O., WolfeR.A., HeldP.J.Delayed graft function: risk factors and implications for renal allograft survival.Transplantation1997; 63: 968–74.
7.
SalahudeenA.K., HaiderN., MayW.Cold ischemia and the reduced long–term survival of cadaveric renal allografts.Kidney Int2004; 65: 713–8.
8.
SalahudeenA.K.Cold ischemic injury of transplanted kidneys: new insights from experimental studies.Am J Physiol Renal Physiol2004; 287: F181–7.
9.
SalahudeenA.K.Cold ischemic injury of transplanted organs: some new strategies against an old problem.Am J Transplant2004; 4: 1.