Introduction: Climate change is one of the major factors making home visiting of patients more challenging and complex. The increasing concentration of greenhouse gases intensifies climate change impacts, prompting a crucial investigation into how environmental shifts are influencing the practice of home visiting and the well-being of individuals and families relying on these services. Objective: To explore the effects of climate change on home visit practices in the Ho Municipality of Ghana. Method: This study employed a qualitative descriptive approach and a purposive sampling technique to recruit 19 participants to reach data saturation. In-depth interviews were conducted, audio recorded, and analyzed using thematic analysis. Results: Three themes (Negative Outcomes of Climate Change, Daily Confronts, and Strategies to Allay these Confronts) were generated. Conclusion: Based on the study's findings, a climate-resilient strategy and evidence-based training on coping mechanisms should be developed to sustain and improve the home visiting program.