Chlamydia trachomatis is the most prevalent sexually transmitted bacterial infection among adolescents in the United States. Chlamydia infections that go untreated may cause complications such as pelvic inflammatory disease, ectopic pregnancy, epididymitis, and infertility. Screening has become easier and more cost-effective with the development of nucleic acid amplification tests. Two common treatments for chlamydia infections are a single dose of azithromycin and a 7-day course of doxycycline. Although the Centers for Disease Control and Prevention has published guidelines regarding screening for and treating chlamydia, only a small percentage of correctional health care facilities adhere to them. Correctional facilities have the opportunity to prevent transmission of chlamydia within a population that has limited access to health care.