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Immune checkpoint inhibitors oncology cancer care subcutaneous administration

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Keytruda Qlex (pembrolizumab and berahyaluronidase alfa-pmph) [prescribing information]. Rahway, NJ: Merck Sharp & Dohme LLC, September 2025.

Opdivo Qvantig (nivolumab and hyaluronidase-nvhy) [prescribing information]. Princeton, NJ: Bristol-Myers Squibb Company, December 2024.

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Keytruda (pembrolizumab) [prescribing information]. Rahway, NJ: Merck Sharp & Dohme LLC, August 2025.

Opdivo (nivolumab) [prescribing information]. Princeton, NJ: Bristol-Myers Squibb Company, June 2025.

Tecentriq (atezolizumab) [prescribing information]. South San Francisco, CA: Genentech, Inc, October 2025.

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. ENHANZE® drug delivery technology: a novel approach to subcutaneous administration using recombinant human hyaluronidase PH20. Drug Deliv 2019; 26: 98–106.

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, et al. Systematic literature review of intravenous versus subcutaneous administration of oncology therapies: a clinical, economic and patient perspective. Cancer Treat Rev 2025; 139: 102974.

Subcutaneous immune checkpoint inhibitors: A new era in oncology care

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