Abstract
Introduction
Chronic myeloid leukemia (CML) is a malignant clonal disorder of hematopoietic stem cells characterized by a translocation of genetic material between chromosomes 9 and 22 resulting in the BCR-ABL fusion oncogene expression. Nilotinib is a potent second-generation tyrosine kinase inhibitor available as first line treatment. Among side effects QTc interval prolongation, pancreatitis, metabolic disorders and skin reactions are the most commonly seen.
Case Report
Here we describe a rare case of lichen planopilaris eruption that developed during therapy with nilotinib.
Management & Outcome
Nilotinib dosage was reduced together with introduction of hydroxychloroquine with progressive improvement of alopecia.
Discussion
Collaboration with dermatologist and nilotinib dose reduction allowed to continue the drug maintaining major molecular response and patient's quality of life.
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Supplementary Material
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