Kaposi sarcoma (KS) is a low-grade mesenchymal angioproliferative disease, mostly observed in immune compromised patients. KS is mostly encountered in HIV-positive or organ transplant patients. The drugs causing immunosuppression have also been associated with KS. Here, we present a KS experience associated with rituximab-based therapy.
BrownEEWhitbyDVitaleF, et al.Virologic, hematologic, and immunologic risk factors for classic Kaposi sarcoma. Cancer2006; 107: 2282–2290.
2.
NaranjoCABustoUSellersEM, et al.A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther1981; 30: 239–245.
3.
VitaleFBriffaDVWhitbyD, et al.Kaposi's sarcoma herpes virus and Kaposi's sarcoma in the elderly populations of 3 Mediterranean islands. Int J Cancer2001; 91: 588–591.
4.
LeeSYJoYMChungWT, et al.Disseminated cutaneous and visceral Kaposi sarcoma in a woman with rheumatoid arthritis receiving leflunomide. Rheumatol Int2012; 32: 1065–1068.
5.
BouattarTKazmouhiLAlhamanyZ, et al.Kaposi's sarcoma following immunosuppressive therapy for vasculitis. Saudi J Kidney Dis Transpl2011; 22: 319–323.
6.
UreshinoHAndoTKojimaK, et al.Rituximab-containing chemotherapy (R-CHOP)-induced Kaposi's Sarcoma in an HIV-negative patient with diffuse large B cell lymphoma. Intern Med2015; 54: 3205–3208.
7.
TremblayCFriedmannD. Kaposi sarcoma associated with iatrogenic immunosuppression: a rare complication of bullous pemphigoid treatment. J Cutan Med Surg2017; 21: 449–451.
8.
TrattnerAHodakEDavidM, et al.The appearance of Kaposi sarcoma during corticosteroid therapy. Cancer1993; 72: 1779–1783.
9.
ErbanSBSokasRK. Kaposi's sarcoma in an elderly man with Wegener's granulomatosis treated with cyclophosphamide and corticosteroids. Arch Intern Med1988; 148: 1201–1203.
10.
CliffordKSDemierreMF. Progression of classic Kaposi's sarcoma with rituximab. J Am Acad Dermatol2005; 53: 155–157.
11.
PantanowitzLFruhKMarconiS, et al.Pathology of rituximab-induced Kaposi sarcoma flare. BMC Clin Pathol2008; 8: 7–7.
12.
LawABRyanGLadeS, et al.Development of Kaposi's sarcoma after complete remission of multicentric Castlemans disease with rituximab therapy in a HHV8-positive, HIV-negative patient. Int J Hematol2010; 91: 347–348.
13.
VoogEMorschhauserFSolal-CelignyP. Neutropenia in patients treated with rituximab. N Engl J Med2003; 348: 2691–2694.
14.
MozessohnLChanKKFeldJJ, et al.Hepatitis B reactivation in HBsAg-negative/HBcAb-positive patients receiving rituximab for lymphoma: a meta-analysis. J Viral Hepat2015; 22: 842–849.
15.
CasperCKrantzEMCoreyL, et al.Valganciclovir for suppression of human herpesvirus-8 replication: a randomized, double-blind, placebo-controlled, crossover trial. J Infect Dis2008; 198: 23–30.
