Pipamperon is a potent neuroleptic drug with many side effects, including prolongation of the QT interval. We report a case of a child treated for leukemia in which prolongation of the QT interval was observed. Physicians and pharmacists should be cautious for drug–drug interactions when pipamperon is prescribed, especially in combination with other QT-prolongating agents. Alternative strategies should be used whenever possible.
Jibson M. Second-generation antipsychotic medications: pharmacology, administration, and side effects. In: Hermann R (ed.) UpToDate. Waltham, MA (accessed 12 January 2017).
2.
Berul C, Seslar P, Zimetbaum P, et al. Acquired long QT syndrome. In: Downey B (ed.) UpToDate. Waltham, MA (accessed 12 January 2017).
3.
Dipiperon. Summary of product characteristics, www.bcfi.be (accessed 21 June 2017).
4.
De PontiFPoluzziECavalliAet al.Safety of non-antiarrhythmic drugs that prolong the QT interval or induce torsade de pointes: an overview. Drug Saf2002; 25: 263–263.
5.
DrewBJAckermanMJFunkMet al.Prevention of torsade de pointes in hospital settings: a scientific statement from the American Heart Association and the American College of Cardiology Foundation. Circulation2010; 121: 1047–1047.
6.
GlassmanAHBiggerJT. Antipsychotic drugs: prolonged QTc interval, torsade de pointes, and sudden death. Am J Psychiatry2001; 158: 1774–1782.
VigiAccess. Uppsala Monitoring Centre, www.vigiaccess.org (accessed 21 June 2017).
12.
DavissWBPatelNCRobbASet al.Clonidine for attention-deficit/hyperactivity disorder: II. ECG changes and adverse events analysis. J Am Acad Child Adolesc Psychiatry2008; 47: 189–198.
13.
KarzAJMcGonigleDPGoldbergJFet al.Effects of aripiprazole on the QTc: a case report. J Clin Psychiatry2015; 76: 1648–1649.
14.
BaschEHeskethPJKrisMGet al.Antiemetics: American Society of Clinical Oncology clinical practice guideline update. J Oncol Pract2011; 7: 395–398.
15.
TriccoACSoobiahCAntonyJet al.Safety of serotonin (5-HT3) receptor antagonists in patients undergoing surgery and chemotherapy: protocol for a systematic review and network meta-analysis. Syst Rev2013; 2: 46–46.
