Capecitabine is a chemotherapeutic agent which is converted to fluorouracil by thymidine phosphorylase in human body. It is one of the commonly used agents in colorectal and metastatic breast cancers. Hand-foot syndrome is most commonly observed adverse effect of capecitabine; however, it has several adverse cutaneous and mucosal effects. To the best of our knowledge, no case with acneiform eruption has been reported so far. Here, we presented a 54-year-old man with development of capecitabine-related acneiform drug eruption.
WalkoCMLindleyC. Capecitabine: a review. Clin Ther2005; 27: 23–44.
2.
CassidyJTwelvesCvan CutsemE. First-line oral capecitabine therapy in metastatic colorectal cancer: a favorable safety profile compared with intravenous 5-fluorouracil/leucovorin. Ann Oncol2002; 13: 566–575.
3.
HeoYSChangHMKimTW. Hand-foot syndrome in patients treated with capecitabine-containing combination chemotherapy. J Clin Pharmacol2004; 44: 1166–1172.
4.
HagueJSIlchyshynA. Lichenoid photosensitive eruption due to capecitabine chemotherapy for metastatic breast cancer. Clin Exp Dermatol2007; 32: 102–103.
Du-ThanhAKlugerNBensallehH. Drug-induced acneiform eruption. Am J Clin Dermatol2011; 12: 233–245.
8.
AgeroALCDuzsaSWBenvenuto-AndradeC. Dermatological side effects associated with the epidermal growth factor receptor inhibitors. J Am Acad Dermatol2006; 55: 657–670.
9.
ArıcanÖÖnverN. A case report of cetuximab-related acneiform eruption. Turk J Dermatol2011; 5: 29–32.
10.
Kimyai-AsadiAJihMH. Follicular toxic effects of chimeric antiepidermal growth factor receptor antibody cetuximab used to treat human solid tumors. Arch Dermatol2002; 138: 129–131.
