Acute pancreatitis is a rare complication of chemotherapy agents. We describe the case of a patient with multiple myeloma who developed acute pancreatitis after treatment with bortezomib, a proteasome inhibitor commonly used in the treatment of this disease. We reviewed the available medical literature on this topic, and found other seven similar cases, all after intravenous bortezomib. Our case is the first one occurring with the subcutaneous route of administration.
Li DestriGInnaoVPetrilloG. A rare pancreatic pseudoaneurysm in patient with acute pancreatitis and multiple myeloma. Ann Ital Chir2011; 82: 301–304.
8.
SolakogluTAkyolPGuneyT. Acute pancreatitis caused by bortezomib. Pancreatology2013; 13: 189–190.
9.
SolakogluTAkarMAktan KoskerT. Is bortezomib a rare cause of acute pancreatitis?JOP2013; 14: 682–683.
10.
MihailaRG. A possible rare complication of bortezomib treatment: acute pancreatitis. Acta Medica Transilvanica2013; 2: 269–271.
11.
GuptaHBansalRKhannaS. An unusual complication of bortezomib therapy: acute pancreatitis. Indian J Nephrol2014; 24: 135–136.
12.
WangHHTsuiJWangXY. Bortezomib-induced acute pancreatitis in a patient with multiple myeloma. Leuk Lymphoma2014; 55: 1404–1405.
13.
TrivediCDPitchumoniCS. Drug-induced pancreatitis: an update. J Clin Gastroenterol2005; 39: 709–716.
14.
TalamoGCavalloFZangariM. Clinical and biological features of multiple myeloma involving the gastrointestinal system. Haematologica2006; 91: 964–967.
15.
KeinoDOhyamaRAshikagaT. Efficacy of chemotherapy combined with bortezomib for two cases of relapsed/refractory acute lymphoblastic leukemia. Rinsho Ketsueki2014; 55: 327–333.
