Anaphylaxis related to drug therapy with 5-HT3 antagonists, in particular, palonosetron has not been reported frequently in the literature. Here a case is presented where the patient possibly had an anaphylactic reaction to palonosetron. In this case report, a 40-year-old female with ovarian cancer developed shortness of breath and hypotension after receiving her palonosetron as part of her premedication for chemotherapy. The patient recovered successfully with fluids and supportive care. This case demonstrates that even after successful treatment in the past with palonosetron a patient may later develop a hypersensitivity to the agent.
Executive summary of disease management of drug hypersensitivity: a practice parameter. Joint Task Force on Practice Parameters, the American Academy of Allergy, Asthma and Immunology, and the Joint Council of Allergy, Asthma and Immunology. Ann Allergy Immunol1999; 83: 665–700.
3.
DittoAM. Drug allergy. In: GrammerLCGreenbergerPA (eds) Patterson’s allergic diseases, 6th ed. Philadelphia: Lippincott Willams & Wilkins, 2002, p. 295.
4.
JickH. Adverse drug reactions: the magnitude of the problem. J Allergy Clin Immunol1984; 74: 555–557.
5.
LazarouJPomeranzBHCoreyPN. Incidence of adverse drug reactions in hospitalized patients: a meta-analysis of prospective studies. JAMA1998; 279: 1200–1205.
6.
RiedlMACasillasAM. Adverse drug reactions: types and treatment options. Am Fam Physician2003; 68: 1781–1791.
7.
NavoMKunthurABadellML. Evaluation of the incidence of carboplatin hypersensitivity reactions in cancer patients. Gynecol Oncol2006; 103(2): 608–613.
8.
Eisai Inc. Aloxi [Package Insert]. Woodcliff Lake, NY: Eisai Inc., September 2008.
9.
ToniniGVincenziBSantiniD. New drugs for chemotherapy-induced nausea and vomiting: focus on palonosetron. Expert Opin Drug Metab Toxicol2005; 1: 143–149.
10.
GuptaYKShanmugamSPPadhyBMGoyalA. Palonosetron induced anaphylaxis in an adult female. Br J Clin Pharmacol2010; 70(1): 149–150.
11.
PerezEAHeskethPSandbachJ. Comparison of single-dose oral granisetron versus intravenous ondansetron in the prevention of nausea and vomiting induced by moderately emetogenic chemotherapy: a multicenter, double-blind, randomized parallel study. J Clin Oncol1998; 16: 754–754.
12.
BenlineTAFrenchJ. Anti-emetic drug effects on cognitive and psychomotor performance: granisetron vs. ondansetron. Aviat Space Environ Med1997; 68: 504–504.
RoujeauJCSternRS. Severe adverse cutaneous reactions to drugs. New Engl J Med1994; 331(19): 1272–1272.
17.
KoshibaHHosokawaKKuboA. Incidence of carboplatin-related hypersensitivity reactions in Japanese patients with gynecologic malignancies. Int J Gynecol Cancer2009; 19(3): 460–465.
18.
MarkmanMKennedyAWebsterK. Clinical features of hypersensitivity reactions to carboplatin. J Clin Oncol1999; 17(4): 1411–1445.
