Bisphosphonates are associated with an important number of inflammatory ocular side-effects including but not limited to conjunctivitis, episcleritis, scleritis, uveitis, and optic neuritis. The intravenous bisphosphonates appear to be linked with more severe ocular inflammation than the orally administered ones. These eye complications tend to resolve with the bisphosphonate discontinuation and can re-occur with its re-challenge. We present here the first case of an acute retinal pigment epithelial detachment associated with pamidronate infusion in a 59-year-old patient with metastatic prostate cancer. J Oncol Pharm Practice (2009) 15: 119—121.
Fraunfelder FW, Fraunfelder FT, Jensvold B.Scleritis and other ocular side effects associated with pamidronate disodium. Am J Ophthalmol2003; 135: 219-22.
2.
Leung S., Ashar BH, Miller RGBisphosphonate-associated scleritis: a case report and review. South Med J2005; 98: 733-5.
3.
des Grottes JM, Schrooyen M., Dumon JC, Body JJRetrobulbar optic neuritis after pamidronate administration in a patient with a history of cutaneous porphyria. Clin Rheumatol1997; 16: 93-5.
4.
Stack R., Tarr K.Drug-induced optic neuritis and uveitis secondary to bisphosphonates. N Z Med J2006; 119: U1888.
5.
Gilhotra JS, Gilhotra AK, Holdaway IM et al. Acute retinal pigment epitheliitis associated with intravenous bisphosphonate. Br J Ophthalmol2006; 90: 798-9.
