Daptomycin has demonstrated antibacterial activity against several antibiotic-resistant strains, including vancomycin-resistant enterococci.1 A paucity of data exists concerning in vivo development of daptomycin resistance of enterococci. We describe an allogeneic bone marrow transplant patient, who was found to have vancomycin-resistant Enterococcus durans bacteremia, which subsequently developed resistance to daptomycin.
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Munoz-Price LS , Lolans K , Quinn JP.Emergence of resistance to daptomycin during treatment of vancomycin-resistant Enterococcus faecalis infection . Clin Infect Dis2005; 41: 565-566 .
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Long JK , Choueiri TK , Hall GS , et al.Daptomycin-resistant Enterococcus faecium in a patient with acute myeloid leukemia . Mayo Clin Proc2005; 80: 1215-1216 .
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Sabol K , Patterson JE , Lewis JS , et al.Emergence of daptomycin resistance in Enterococcus faecium during daptomycin therapy . Antimicrob Agents Chemother2005; 49: 1664-1665 .
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Mangili A , Bica I , Snydman DR , et al.Daptomycin-resistant, methicillin-resistant Staphylococcus aureus bacteremia . Clin Infect Dis2005; 40: 1058-1060 .
8.
Silverman JA , Oliver N , Andrew T , et al.Resistance studies with daptomycin . Antimicrob Agents Chemother2001; 45: 1799-1802 .
9.
Cui L , Tominaga E , Neoh H , et al.Correlation between reduced daptomycin susceptibility and vancomycin resistance in vancomycin-intermediate Staphylococcus aureus . Antimicrob Agents Chemother2006; 50: 1079-1082 .
10.
Jorgensen JH , Crawford SA , Kelly CC , et al.In vitro activity of daptomycin against vancomycin-resistant enterococci of various Van types and comparison of susceptibility testing methods . Antimicrob Agents Che-mother2003; 47: 3760-3763 .
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Wise R , Andrews JM , Ashby JP.Activity of daptomycin against Gram-positive pathogens: a comparison with other agents and the determination of a tentative breakpoint . J Antimicrob Chemother2001; 48: 563-567 .
12.
Johnson AP , Mushtaq S , Warner M , et al.Calcium-supplemented daptomycin Etest strips for susceptibility testing on Iso-Sensitest agar . J Antimicrob Chemother2004; 53: 860-862 .
13.
Cubist Pharmaceuticals . Prescribing information on Cubicin®, daptomycin. Lexington, MA , 2005.
14.
American Society for Microbiology, 2002: A-1387-A-1387 .
