Child maltreatment is a pervasive social problem often perpetuated by family members and is related to a wide array of negative life outcomes. Although substance use is an outcome commonly associated with experiences of child maltreatment, not all individuals who experience maltreatment struggle with such issues. Many individuals can positively adapt to experiences of maltreatment based on levels of resilience and susceptibility. Research suggests that genetic differences may partly explain why negative outcomes develop for some, but not for others. Few studies have examined the extent to which genetic and environmental factors influence the longitudinal association between child maltreatment and varying forms of substance use, leaving a fundamental gap in our current understanding of this association. The current study aims to address this gap by analyzing a sample of twins from the National Longitudinal Study of Adolescent to Adult Health (Add Health). Findings from a series of univariate and bivariate biometric models reveal that the longitudinal associations between maltreatment, cigarette use, and marijuana use are accounted for by additive genetic and nonshared environmental factors. Moreover, the magnitude of the contribution varies across unique subgroups of cigarette and marijuana use. Directions for future research and theoretical implications are discussed.
BeaverK. M.BoutwellB. B.BarnesJ. C.CooperJ. A. (2009). The biosocial underpinnings to adolescent victimization: Results from a longitudinal sample of twins. Youth Violence and Juvenile Justice, 7(3), 223–238. https://doi.org/10.1177/1541204009333830
2.
BeharieN.ScheidellJ. D.QuinnK.McGorrayS.VaddipartiK.KumarP. C.KhanM. R. (2019). Associations of adolescent exposure to severe violence with substance use from adolescence into adulthood: Direct versus indirect exposures. Substance Use and Misuse, 54(2), 191–202. https://doi.org/10.1080/10826084.2018.1495737
3.
CammackA. L.HaardörferR.SugliaS. F. (2019). Associations between child maltreatment, cigarette smoking, and nicotine dependence in young adults with a history of regular smoking. Annals of Epidemiology, 40(1), 13–20. https://doi.org/10.1016/j.annepidem.2019.10.003
ConnollyE. J. (2020). Further evaluating the relationship between adverse childhood experiences, antisocial behavior, and violent victimization: A sibling - comparison analysis. Youth Violence and Juvenile Justice, 18(1), 3–23. https://doi.org/10.1177/1541204019833145
6.
ConnollyE. J.KavishN. (2019). The causal relationship between childhood adversity and developmental trajectories of delinquency: A consideration of genetic and environmental confounds. Journal of Youth and Adolescence, 48(2), 199–211. https://doi.org/10.1007/s10964-018-0960-0
FaganA. A.Lee Van HornM.AntaramianS.HawkinsJ. D. (2011). How do families matter? Age and gender differences in family influences on delinquency and drug use. Youth Violence and Juvenile Justice, 9(2), 150–170. https://doi.org/10.1177/1541204010377748
9.
FergusonE. G.MannesZ. L.EnnisN. (2019). Is marijuana use associated with lower inflammation? Results from waves III and IV of the National Longitudinal Study of Adolescent to Adult Health. Drug and Alcohol Dependence, 198(1), 162–167. https://doi.org/10.1016/j.drugalcdep.2019.01.021
10.
HancockD. B.WangJ. C.GaddisN. C.LevyJ. L.SacconeN. L.StitzelJ. A.GoateA.BierutL. J.JohnsonE. O. (2015). A multiancestry study identifies novel genetic associations with CHRNA5 methylation in human brain and risk of nicotine dependence. Human molecular genetics, 24(20), 5940–5954.
11.
HandleyE. D.RogoschF. A.CicchettiD. (2017). From child maltreatment to emerging adult problem drinking: Identification of a multilevel internalizing pathway among African American youth. Development and Psychopathology, 29(5), 1807–1821. https://doi.org/10.1017/S0954579417001419
12.
HarrisK. M. (2013). The add health study: Design and accomplishments (pp. 1–22). Chapel Hill: Carolina Population Center, University of North Carolina at Chapel Hill.
13.
JaffeeS. R.CaspiA.MoffittT. E.TaylorA. (2004). Physical maltreatment victim to antisocial child: Evidence of an environmentally mediated process. Journal of Abnormal Psychology, 113(1), 44–55. https://doi.org/10.1037/0021-843X.113.1.44
14.
JamiE. S.HammerschlagA. R.BartelsM.MiddeldorpC. M. (2021). Parental characteristics and offspring mental health and related outcomes: A systematic review of genetically informative literature. Translational Psychiatry, 11(1), 1–38. https://doi.org/10.1038/s41398-021-01300-2
15.
JohnsonR. J.RossM. W.TaylorW. C.WilliamsM. L.CarvajalR. I.PetersR. J. (2005). A history of drug use and childhood sexual abuse among incarcerated males in a county jail. Substance Use & Misuse, 40(2), 211–229. https://doi.org/10.1081/ja-200048457
MillsR.AlatiR.StrathearnL.NajmanJ. M. (2014). Alcohol and tobacco use among maltreated and non ‐ maltreated adolescents in a birth cohort. Addiction, 109(4), 672–680. https://doi.org/10.1111/add.12447
18.
NylundK. L.AsparouhovT.MuthénB. O. (2007). Deciding on the number of classes in latent class analysis and growth mixture modeling: A monte carlo simulation study. Structural Equation Modeling: A Multidisciplinary Journal, 14(4), 535–569. https://doi.org/10.1080/10705510701575396
19.
PezzoliP.AntfolkJ.HatoumA. S.SanttilaP. (2019). Genetic vulnerability to experiencing child maltreatment. Frontiers in Genetics, 10(852), 1–10. https://doi.org/10.3389/fgene.2019.00852
20.
PhilibertR. A.BeachS. R.GunterT. D.BrodyG. H.MadanA.GerrardM. (2010). The effect of smoking on MAOA promoter methylation in DNA prepared from lymphoblasts and whole blood. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 153(2), 619–628.
21.
PittnerK.Van IjzendoornM. H.AlinkL. R.BuismanR. S.Compier-de BlockL. H.Van Den BergL. J.Bakermans-KranenburgM. J. (2019). The genetic and environmental etiology of child maltreatment in a parent - based extended family design. Development and Psychopathology, 31(1), 157–172. https://doi.org/10.1017/S0954579418001608
22.
PoldermanT. J.BenyaminB.De LeeuwC. A.SullivanP. F.Van BochovenA.VisscherP. M.PosthumaD. (2015). Meta - analysis of the heritability of human traits based on fifty years of twin studies. Nature Genetics, 47(7), 702–709. https://doi.org/10.1038/ng.3285
23.
Prom-WormleyE. C.EbejerJ.DickD. M.BowersM. S. (2017). The genetic epidemiology of substance use disorder: A review. Drug and Alcohol Dependence, 180, 241–259. https://doi.org/10.1016/j.drugalcdep.2017.06.040.
SchückherF.SellinT.FahlkeC.EngströmI. (2018). The impact of childhood maltreatment on age of onset of alcohol use disorder in women. European Addiction Research, 24(6), 278–285. https://doi.org/10.1159/000494766
26.
SchuckitM. A.SmithT. L.KalmijnJ. (2013). Relationships among independent major depressions, alcohol use, and other substance use and related problems over 30 years in 397 families. Journal of Studies on Alcohol and Drugs, 74(2), 271–279. https://doi.org/10.15288/jsad.2013.74.271
27.
SchwartzJ. A.WrightE. M.ValgardsonB. A. (2019). Adverse childhood experiences and deleterious outcomes in adulthood: A consideration of the simultaneous role of genetic and environmental influences in two independent samples from the United States. Child Abuse & Neglect, 88, 420–431. https://doi.org/10.1016/j.chiabu.2018.12.022.
28.
UdryJ. R. (2003). The national longitudinal study of adolescent health (Add Health), Waves I and II, 1994–1996; Wave III, 2001–2002. Carolina Population Center, University of North Carolina at Chapel Hill.
29.
Van derKnaapSchaeferJ. M.FrankenI. H. A.VerhulstF. C.vanOortRieseH. (2014). Catechol‐O‐methyltransferase gene methylation and substance use in adolescents: the TRAILS study. Genes, Brain and Behavior, 13(7), 618–625.
30.
WalshC.MacMillanH. L.JamiesonE. (2003). The relationship between parental substance abuse and child maltreatment: Findings from the ontario health supplement. Child Abuse & Neglect, 27(12), 1409–1425. https://doi.org/10.1016/j.chiabu.2003.07.002
WidomC. S.SchuckA. M.WhiteH. R. (2006). An examination of pathways from childhood victimization to violence: The role of early aggression and problematic alcohol use. Violence and Victims, 21(6), 675–690. https://doi.org/10.1891/0886-6708.21.6.675
33.
YoungS. E.RheeS. H.StallingsM. C.CorleyR. P.HewittJ. K. (2006). Genetic and environmental vulnerabilities underlying adolescent substance use and problem use: General or specific?Behavior Genetics, 36(4), 603–615. https://doi.org/10.1007/s10519-006-9066-7
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