Abstract
Background:
The usage of antimicrobials is commonly associated with the emergence of resistant phenotypes in microorganisms. Health care facilities are required to measure antimicrobial consumption and monitor consumption trends to promote its rationale use. The aim of this study is to estimate the antimicrobial consumption in the hospital using the defined daily dose (DDD) methodology and to determine the percentage of antibiotics consumed as per the Access, Watch, and Reserve classification.
Methods:
This retrospective observational study was conducted at Apollo Proton Cancer Centre, Chennai over a period of 1 year from January 2023 to December 2023. All inpatients admitted to the multidisciplinary critical care unit, surgical intensive care units, and wards were included in the study. Antimicrobial stewardship data collected by the clinical pharmacist were reviewed retrospectively. The calculation of antibiotic consumption was done using the DDD/1,000 patient-days formula, and the average of it was estimated using Microsoft Excel 2022 edition.
Results:
A total of 5,029 inpatients were included in the study. The average antimicrobial consumption for the high-end antibiotics, restricted antifungals, and other antibiotics was found to be 637.9, 87.6, and 559.2, respectively. The most commonly consumed antibiotic was meropenem (51.4%) followed by cefoperazone–sulbactam (34.7%), piperacillin–tazobactam (34.2%), and teicoplanin (15.2%).
Conclusion:
In this study, the utilization of Watch (73%) group antibiotics was more than that of the Access (18%) group and Reserve (9%) antibiotics. These findings suggest an urgent need for strengthening the existing antimicrobial stewardship program in the health care setting to improve the antibiotic metrics.
Keywords
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