Nordström M. , Lindblad B., Anderson H., et al. Deep venous thrombosis and occult malignancy: an epidemiological study. Br Med J1994;308:891.
2.
Prandoni P., Lensing Awa, Büller HR, et al. Deep vein thrombosis and the incidence of subsequent symptomatic cancer. N Engl J Med1992;327:1128.
3.
Nordström M. , Lindblad B., Bergqvist D., Kjellström T.A prospective study of the incidence of deep vein thrombosis within a defined urban population . J Int Med1992;232:155.
4.
Monreal M., Lafoz E., Casals A., et al.Occult cancer in patients with deep venous thrombosis. Cancer1991;67:541.
5.
Aderka D., Brown A., Zellikovski A., Pinkhas J.Idiopathic deep vein thrombosis in an apparently healthy patient as a premonitory sign of occult cancer. Cancer1986;57:1846.
6.
Constantini V., Zacharski LRFibrin and cancer. Thromb Haemost1993;69:406.
7.
Geczy CLCellular mechanism for the activation of blood coagulation. Int Rev Cytol1994;152:49.
8.
Lindahl AKBlood coagulation inhibitors in malignant disease. Norwegian Cancer Society, Oslo, Norway, 1992 .
9.
Contrino J., Hao G., Kreutzer DL, Rickles FRIn situ detection of tissue factor in vascular endothelial cells: correlation with the malignant phenotype of human breast disease. Nat Med1996;2:209.
10.
Nicolaides AN , Irving D.Clinical factors and the risk of deep venous thrombosis. In: Nicolaides AN , ed. Thromboembolism. Lancaster: MTP Co., Ltd, 1975:193.
11.
Pinsky DJ, Yan SF, Lawson CH, et al. Hypoxia and modification of the endothelium: Implications for regulation of vascular hemostatic properties. Cell Bio1995;6:283.
12.
Tempelhoff v G-F, Heilmann L.Alterations in the clotting system and hemorrheologie: early signs of thrombophilia in patients with different gynecologic malignancies [Abstract]. Br J Haematol1994;87(suppl 1);191.
13.
Lowe Gdo.Blood rheology, hemostasis and vascular disease. In: Bloom AL, Forbes CD, Thomas DP, Tuddenham ECD , eds. Haemostasis and Thrombosis. New York: Churchill Livingstone, 1994 .
14.
Miller B., Heilmann L.Hemorrheological parameters in patients with gynecologic malignancies . Gynecol Oncol1989;33:177.
15.
Tempelhoff v G-F, Dietrich M., Niemann F., et al. Blood coagulation and thrombosis in patients with ovarian malignancy. Thromb Haemost1997;77:456.
16.
Ogawa S., Gerlach A., Esposito C., et al. Hypoxia modulates the barrier in coagulant function of cultured bovine endothelium. J Clin Invest1990;85:1090.
17.
Jain RKTransport of molecules across tumor vasculature. Cancer Met Rev1987;6:559.
18.
Warren BAThe vascular morphology of tumors. In: Peterson HJ, ed. Tumor Blood Circulation, Angiogenesis, Vascular Morphology and Blood Flow in Experimental and Human Tumours. Boca Raton: CRC Press, 1979.
19.
Walsh JJ, Bonnar J., Wright FWA study of pulmonary embolism and deep leg vein thrombosis after major gynecologic surgery using labelled fibrinogen phlebography and lung scanning . J Obstet Gynecol Br1984 ;81:311.
20.
Adolf J., Buttermann JG, Weidenbach A., Gmeinder F.Optimierung der postoperativen Thromboseprophylaxe in der Gyndkologie . Geburtsh u Frauenheilk1978;38:98.
21.
Ballard RM, Bradley-Watson PJ, Johnstone FD, et al. Low dose of subcutaneous heparin in the prevention of deep vein thrombosis after gynecological surgery. J Obstet Gynecol Br1973;80:469.
22.
Bonnar J., Walsh J.Prevention of thrombosis after pelvic surgery by British Dextran 70 . Lancet1972;II:614.
23.
Turner G., Brooks J.The efficacy of graduated compression stockings in the prevention of deep vein thrombosis after major gynecologic surgery. Br J Obstet Gynecol1984 ;91:588.
24.
Clarke-Pearson DL, deLong E., Synan IS, et al. A controlled trial of two dose low dose heparin regimens for the prevention of postoperative deep vein thrombosis . Obstet Gynecol1990 ;75:684.
25.
Clarke-Pearson DL, Synan I., Hinshaw W., et al. Prevention of postoperative venous thromboembolism by external pneumatic calf compression in patients with gynecologic malignancy. Obstet Gynecol1984;63:92.
26.
Clarke-Pearson DL, Coleman RE, Synan IS, et al. Venous thromboembolism prophylaxis in gynecologic oncology: a prospective controlled trial of low dose heparin . Am J Obstet Gynecol1983; 145:606.
27.
Clarke-Pearson DL, Creasman WI, Coleman RE, et al. Perioperative external pneumatic calf compression as thromboembolism prophylaxis in gynecologic oncology: report of a randomized controlled trial: Gynecol Oncol1984;18:226.
28.
Heilmann L. , Kruck A., Schindler E.Thromboseprophylaxe in der Gyndkologie: Doppelblindvergleich zwischen niedermolekularen (LMWH) und unfraktionierten (UFH) Heparin. Geburtsh und Frauenheilk1989;48:803.
29.
Hohl MK, Lüscher KP, Tickey J., et al. Prevention of postoperative thromboembolism by Dextran 70 or low dose heparin. Obstet Gynecol1980;55:497.
30.
Kunz S., Drähne A., Briel RCPropkylaxe der postoperativen Thromboembolie—Erfahrungen mit Heparin-Dihydergot in der Gynäkologie. In: Pabst HW, Maurer G, eds. Postoperative Thromboembolie-Prophylaxe . Stuttgart: Schattauer, 1977.
31.
McCarthy TG , McQueen J., Johnstone FD, et al. A comparison of low dose subcutaneous heparin and intravenous dextran 70 in the prophylaxis of deep venous thrombosis after gynecological surgery. J Obstet Gynecol Br1974;81:486.
32.
Taberner DA , Poller L., Bursletor RW, Jones JBOral anticoagulants controlled by the British comparative thromboplastin versus low dose heparin in prophylaxis of deep vein thrombosis. Br Med J1978;1:272.
33.
Clarke-Pearson DL, Synan IS, Dodge R., et al. A randomized trial of low dose heparin and intermittent pneumatic calf compression for the prevention of deep venous thrombosis after gynecologic oncology surgery . Am J Obstet Gynecol1993;168:1146.
34.
Heilmann L. , von Tempelhoff GF, Herrle B., et al. Low dose heparin versus niedermolekulares Heparin zur Thromboseprophylaxe in der operativen gyndkologischen Onkologie . Geburtsh u Frauenheilk1997;57:1.
35.
Kakkar VVPrevention of venous thromboembolism. In: Bloom AI, Forbes CD, Thomas DP, Tuddenham EGD , eds. Haemostasis and Thrombosis. London : Churchill Livingstone, 1994.
36.
Gallus A., Cade J., Ockelford P., et al. Orgaran (ORG 10172) or Heparin for preventing venous thrombosis after elective surgery for malignant diseases? A double blind randomized comparison . Thromb Haemost1993;70:562.
37.
Kakkar VVEffectiveness and safety of low molecular weight heparins (LMWH) in the prevention of venous thrombembolism (VTE). Thromb Haemost1995;74:364.
38.
Borstadt E. , Urdahl K., Handerland G., Abildgaard U.Comparison of low molecular weight heparin vs. unfractionated heparin in gynecological surgery. Acta Obstet Gynecol Scand1988;67:99.
39.
Fareed J., Callas DJ, Hoppensteadt D., et al. Recent developments in antithrombotic agents. Exp Opin Invest Drugs1995;4:389.
40.
Bona RD, Sivjee KY, Hickey ADThe efficacy and safety of oral anticoagulance in patients with cancer . Thromb Haemost1995;74: 1055.
41.
Friend JR, Kakkar VVDeep vein thrombosis in obstetric and gynecological patients. In: Kakkar VV, Jonkar ZJ, eds. Thromboembolism Diagnosis and Treatment . New York: Churchill Livingston , 1972 .
42.
Gore M., Miller KE, Soong SJ, et al. Vascular plasminogen activator levels and thromboembolic disease in patients with gynecologic malignancy. Am J Obstet Gynecol1984; 149:830.
43.
Clahsen PC, van de Velde CJH, Julien JP, et al. Thromboembolic complications after perioperative chemotherapy in women with early breast cancer: a European organization for research and treatment of cancer breast cancer cooperative group study. J Clin Oncol1994;12:1266.
44.
Saphner T., Tormey DC, Gray R.Venous and arterial thrombosis in patients who received adjuvant therapy for breast cancer. J Clin Oncol1991 ;9:286.
45.
Weiss RB, Dormey DC, Holland JFVenous thrombosis during multimodal treatment of primary breast carcinoma . Cancer Treat Rep1981;65:677.
46.
Levine M., Hirsh J., Gent M., et al. Double-blind randomized of very low dose warfarin for prevention of thromboembolism in stage IV breast cancer. Lancet1994;343:886.
47.
Tempelhoff v G-F, Dietrich M., Hommel G., Heilmann L.Blood coagulation during adjuvant epirubicin/cyclophosphamid chemotherapy in patients with primary operable breast cancer. J Clin Oncol1996 ;14:2560.
48.
Goodnough LT , Saito H., Manni A.Increased incidence of thromboembolism in stage IV breast cancer patients treated with five drug chemotherapy regimen: a study of 159 patients. Cancer1984; 54:1264.
49.
Canney PA, Wilkinson PMPulmonary embolism in patients receiving chemotherapy for advanced ovarian cancer. Europ J CancerClin Oncol1985 ;21:585.
50.
Bick RL, Fekete LF, Wilson WLAdriamycin and fibrinolysis. Thromb Res1976 ;8:467.
51.
Canobbio L. , Fassio T., Ardizzoni A., et al. Hypercoagulable state induced by cytostatic drugs in stage II breast cancer patients. Cancer1986;58:1032.
52.
Fisher B., Constantino J., Redmond C.Randomized clinical trial evaluating tamoxifen in the treatment of patients with node negative breast cancer who have estrogen-positive tumors . N Engl J Med1989;320:474.
53.
Pollow K., Kreienberg R., Juchem M., Hoffmann G.Hochdosierte Medroxyprogesteronacetat (MPA)-therapie beim fortgeschrittenen mammakarzinom unter besonderer berucksichtigung der MPAserumspiegel. Tumordiagn u Ther1995;14:49.
54.
Rutqvist LE , Mattson A.Cardiac and thromboembolic morbidity among postmenopausal women with early stage breast cancer in randomized trial of adjuvant tamoxifen. J Natl Cancer Inst1993 ; 85:1398.
55.
Pemberton KD , Melissari E., Kakkar VVThe influence of tamoxifen in vivo on the main natural anticoagulants and fibrinolysis. Blood Coag Fibrinolys1993;4:935.
56.
Lipton A., Harvey HA, Hamilton RWVenous thrombosis as a side effect of tamoxifen treatment. Cancer Treat Rep1984;68:887.
57.
McDonald CC, Alexander FE, Whyte BW, et al. Cardiac and vascular morbidity in women receiving adjuvant tamoxifen for breast cancer in a randomized trial. Br Med J1995;311:977.
58.
Hayes DF, van Zyl JA, Hacking A., et al. Randomized comparison of tamoxifen and two separate doses of toremifen in postmenopausal patients with metastatic breast cancer. J Clin Oncol1995; 13:2556.
59.
Anker G., Lonning PE, Ueland PM, et al. Plasma levels of the atherogenic amino acid homocysteine in post-menopausal women with breast cancer treated with tamoxifen. Int J Cancer1995;60: 365.
60.
Bastert G., Michel RIHochdosierte Gestagentherapie mit medroxyprogesteronacetat (HD-MPA) beim metastasierenden Mammakarzinom. Med Welt1983;34:378.
61.
Castiglione-Gertsch M., Pampallona S., Varini M., et al. Primary endocrine therapy for advanced breast cancer: To start with tamoxifen or with medroxyprogesteron acetate ? Ann Oncol1993; 4:735.
62.
Davila E., Vogel Chl, East D., et al. Clinical trial of high dose oral medroxyprogesteron acetate in the treatment of metastatic breast cancer and review of the literature . Cancer1988;61:2161.
63.
Della CunaRobustelli G., Pellegrini A., Ganzina F.Chemotherapy and hormonal treatment of advanced breast cancer. Farmitalia, Milano, 1982.
64.
Merckle E., Bähr I., Henke A., et al. Sequenz und intervalltherapie beim metastasierende mammakarzinom mit tamoxifen und MPA. Tumordiagn u Ther1994 ;15:104.
65.
Pannuti F., Martoni A., Cilenti G., et al. Adjuvant therapy for operable breast cancer with medroxyprogesteron acetate alone in postmenopausal patients or in combination with CMF in premenopausal patients. Eur J Cancer Clin Oncol1988;24:423.
66.
Samonis G., Magioris AN, Bafaloukos D., Razis DVProspective randomized study of aminoglutethimide (AG) versus medroxyprogesterone acetate (MPA) versus AG + MPA in generalized breast cancer. Oncology1994 ;51:411.
67.
Parnes HL, Abrams JS, Tchekmeydyian NS, et al. A phase I/II study of high dose megestrol acetat in the treatment of metastatic breast cancer. Breast Cancer Res Treat1991;18:171.
68.
Tchekmedyian NS, Tait N., Abrams J., Aisner J.High-dose megestrol acetate in the treatment of advanced breast cancer. Semin Oncol1988 ;15(suppl 1):44.
69.
Anzivino F. , Pollutri E., Andollina A., et al. High doses of medroxyprogesteron acetate in oncology: Effects on the main parameters involved in blood clotting. IRCS Med Sc1997;5:577.
70.
Yamamoto H. , Noguchi S., Miyauchi K., et al. Changes in hamatologic parameters during treatment with medroxyprogesterone acetate for breast cancer . Jpn J Cancer Res1991 ;82:420.
71.
Kakkar VV, Cohen AT, Edmonson RA, et al. Low molecular weight versus standard heparin for prevention of venous thromboembolism after major abdominal surgery. Lancet1993;341:259.
72.
Settembrini PG, Olivari N., Codemo R., et al. Evaluation of intra-and post-operative tolerability of the LMWH CY 216 in neoplastic patients [Abstract]. Thromb Haemost1991 ;65:928.
73.
Hommes DW, Bura A., Mazzolai L., et al. Subcutaneous heparin compared with continuous intravenous heparin administration in the initial treatment of deep vein thrombosis. Ann Int Med1992; 116:279.
74.
Zacharski LR , Henderson WG, Forman WBBleeding complications from warfarin anticoagulation in patients with malignancy. J Med1985;16:535.
75.
Prandoni P.Prevention and treatment of deep vein thrombosis in cancer patients. Vessels1996;2:31.
76.
Bonnar J.Venous thromboembolism and gynecologic surgery. Clin Obstet Gynecol1985;28:432.
77.
Tyrell DJ, Kilfeather ST, Page CBTherapeutic uses of heparin beyond its traditional role as an anticoagulant . TiPs1995;16:198.
Hayes DFAngiogenesis and breast cancer. In: Shapiro CH, Henderson IC, eds. New directions in breast cancer: research and therapeutics. Hematol/OncolClin North Am1994;8:51.
80.
Norrby K., Ostergaard P.Basic fibroblast growth factor mediated de novo angiogenesis is more effectively suppressed by low molecular weight heparin than by high molecular weight heparin . Int J Microcirc Clin Exp1996;16:8.
81.
Wellstein A.Growth factor targeted and conventional therapy of breast cancer. Breast Cancer Res Treat1994;31:141.
Hirsh J., Siragusa S., Cosmi B., Ginsberg JSLow molecular weight heparin (LMWH) in the treatment of patients with an acute venous thrombembolism. Thromb Haemost1995 ;74:360.
84.
Hull RB, Raskob GE, Pineo GF, et al. Subcutaneous low molecular weight heparin compared with intravenous heparin in the treatment of proximal vein thrombosis. N Engl J Med1992;326:975.
85.
Hull RB, Pineo GFTherapeutic use of low molecular weight heparins: Knowledge to date and their application to therapy. Semin Thromb Hemost1994;20;339.
86.
Lensing Awa , Prins MH, Davidson BL, Hirsh J.Treatment of deep venous thrombosis with low molecular weight heparins. A metaanalysis. Arch Int Med1995;155:601.
87.
Prandoni P. , Lensing Awa, Büller HR, et al. Comparison of subcutaneous low moleculare weight heparin with intravenous standard heparin in proximal deep vein thrombosis . Lancet1992;339: 441.