Controversies in Antithrombotic Therapy in Cardiovascular Diseases

Abstract

Antithrombotic treatment became an important point in human medical treatment. Dicoumarols, heparin, aspi rin, and more recently, direct antithrombins and platelet glyco protein IIb/IIIa receptor blockers are the most frequent medi cations used as antithrombotics. The role of these drugs in the treatment of cardiovascular diseases remains controversial. Low-dose aspirin (80-100 mg/day) should be used for second ary prevention in patients with a history of coronary disease. Primary prevention in patients with no risk factors is not rec ommended. Studies using oral anticoagulant therapy indicated that long-term therapy achieves substantial benefit in arterial complications in patient survivors of myocardial infarction. Combined therapy of aspirin and a higher dose of oral antico agulant than that used in the CARS trial seem necessary after myocardial infarction, and further studies should be under taken. In the treatment of unstable angina, the combined use of aspirin and unfractioned heparin (UFH) is widely accepted. Low molecular weight heparin (LMWH) was also proposed for the treatment of these patients, but the beneficial effect of LMWH over UFH is a matter of discussion, and more prospec tive studies with different LMWHs should be undertaken be fore reaching a definitive answer. The use of hirudin needs additional studies because its superiority over heparin is un- proved. The initial clinical experience with blockers/inhibitors of platelet glycoprotein IIb/IIIa receptors has been promising, although some increase of bleeding was reported. According to published trials on the use of antiplatelet drugs and antithrom botic therapy in the prevention of acute closure after PTCA or after stent implantation, antithrombotic therapy decreased the incidence of abrupt closure or reocclusion at 30 days postan gioplasty, but neither antiplatelet agents nor other pharmaco logical agents have been shown to reduce significantly the rate of restenosis. Finally, oral anticoagulant in a target INR of 2.0 to 3.0 together with aspirin 100 mg/day provide good protec tion from thromboembolism and diminish the rate of minor bleeding complications in patients with cardiac valve replace ment.