It is well-known that pulmonary embolism sometimes accompanies a bronchoconstrictive symptom, but the precise mechanism is not clearly understood. We report a unique case of antithrombin (AT) abnormality with no heparin-binding activity accompanied by pulmonary thromboembolism and asthmatic symptoms. Keeping AT activity >60% by infusion of AT concentrates, we successfully treated the asthmatic symptom, which did not respond to ordinary treatment for bronchial asthma and the anticoagulant therapy by warfarin potassium for pulmonary thromboembolism. Key Words: Antithrombin concentrates—Bronchial asthmatic symptom—Pulmonary thromboembolism—Antithrombin abnormality with no heparin binding activity
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References
1.
Sakuragawa N. , Takahashi K., Kondo S., Koide T.Antithrombin III Toyama: A hereditary abnormal antithrombin III of a patient with recurrent thrombophlebitis. Thromb Res1983;31:305.
2.
Emoto M., Tanimizu I., Sakuragawa N.Antithrombin III assay without influence of heparin cofactor II. Thromb Res1990;57:729.
3.
Koide T., Sakuragawa N., Odani S., Takahashi K., Ono T.Antithrombin III Toyama: Replacement of arginine-47 by cysteine in hereditary abnormal antithrombin III that lacks heparin-binding ability. Proc Natl Acad Sci USA1984;81:289.
4.
Braman SS, Davis SMWheezing in elderly asthma and other causes. Geriatr Clin N Am1986;2:269.
5.
Hollingsworth HMWheezing and stridor. Clin Chest Med1987; 8:231.
6.
Sasahara AA, Cannilla JE, Morse RL, Sidd JJ, Tremblay GMClinical and physiologic studies in pulmonary thromboembolism. Am J Cardiol1967;20:10.
7.
Gurewich V., Cohen ML, Thomas DPHumoral factors in massive pulmonary embolism: An experimental study. Am Heart J1968; 76:784.
8.
Gurewich V., Thomas D., Stein M., Wessler S.Bronchoconstriction in the presence of pulmonary embolism. Circulation1963;27:33.
9.
Windebank WJ , Boyd G., Moran F.Pulmonary thromboembolism presenting as asthma . Br Med J1973;13:90.
