Fibrinogen,Hematocrit,and Platelets in Mild Kidney Dysfunction and the Role of Uric Acid: An Italian Male Population Study

Indeed there is a close relationship between estimated glomerular filtration rate (eGFR) and serum uric acid (SUA) levels. ¹ This may explain the concomitant improvement in SUA levels and eGFR observed in patients with coronary heart disease (CHD) or peripheral arterial disease after prescribing a statin.^2–4 Of additional interest, in the CHD studies,^2,3 SUA was an independent predictor of CHD recurrent events.

We reviewed the evidence showing an association between SUA levels and abnormal liver function tests (LFTs) in patients with nonalcoholic fatty liver disease (NAFLD). ⁵ We also showed that NAFLD was associated with a greater risk of vascular events in patients with CHD. ⁶ Furthermore, in this study, ⁶ patients with NAFLD on a statin benefited more from lipid-lowering treatment than those without NAFLD in terms of a decrease in vascular events. In this context, does the study by Corrêa Leite ¹ discusses about LFTs If yes, we would be interested to know whether there are any significant correlations between LFTs and SUA levels. ⁵

Hyperuricemia seems to be more frequent in patients with metabolic syndrome, a condition that is associated with increased risk of vascular events. ⁷ It follows that we would be interested to know whether the population described by Corrêa Leite ¹ could be reanalyzed as those with and without metabolic syndrome.

Several drugs can influence SUA levels. ⁸ These associations complicate the definition of the contribution of SUA to the risk of vascular events.