Response Variation in Patients Treated With Clopidogrel

FDA Drug Safety Communication. Reduced effectiveness of Plavix (clopidogrel) in patients who are poor metabolizers of the drug (2010, March 12). Retrieved April 7, 2010, from FDA website: http://www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformationforpatientsandProviders/ucm203888.htm

Davi G. , Patrono C. Platelet activation and atherothrombosis. N Engl J Med. 2007;357(24): 2482-2494.

Yusuf S. , Zhao F. , Mehta SR , Chrolavicius S. , Tognoni G. , Fox KK Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation. N Engl J Med. 2001;345(7): 494-502.

Steinhubl SR , Berger PB , Mann JT 3rd , et al. Early and sustained dual oral antiplatelet therapy following percutaneous coronary intervention: a randomized controlled trial. J Am Med Assoc. 2002;288(19): 2411-2420.

Meadows TA , Bhatt DL Clinical aspects of platelet inhibitors and thrombus formation. Circ Res. 2007;100(9): 1261-1275.