A Functional Ser413/Ser413 PAI-2 Polymorphism Is Associated With Susceptibility and Damage Index Score in Systemic Lupus Erythematosus

Abstract

Systemic lupus erythematosus in some cases is characterized for development of thrombotic events with a significantly increased risk of mortality. The frequencies and clinical associations of Ser⁴¹³/Cys⁴¹³ PAI-2 polymorphism in 40 systemic lupus erythematosus, 50 rheumatoid arthritis patients, and 100 healthy subjects were investigated. The Ser⁴¹³/Ser⁴¹³ genotype frequency was 53% (lupus), 36% (rheumatoid arthritis), and 35% (healthy subjects). The Ser⁴¹³ allele was associated with systemic lupus erythematosus (P = .04, odds ratio = 1.76, 95% confidence interval = 1.01-3.06). In all, 4 patient carriers of Ser⁴¹³/Ser⁴¹³ genotype, developed thrombotic events. The lupus patients identified with Ser⁴¹³/Ser⁴¹³ genotype showed an increased damage (57%), compared with Ser⁴¹³/Cys⁴¹³ and Cys⁴¹³/Cys⁴¹³ genotypes, with significant difference (P = .03). These findings suggest an association of Ser⁴¹³/Ser⁴¹³ genotype with greater damage index score and Ser⁴¹³ allele with systemic lupus erythematosus. Besides, PAI-2 polymorphism could be related with thrombotic phenomena in systemic lupus erythematosus

Keywords

plasminogen activator inhibitor 2 polymorphism SLE RA

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