The Glycoprotein IIIa PLA1/A2 Polymorphism—A Defect Responsible for the Sticky Platelet Syndrome?

Bick RL . Sticky platelet syndrome: A common cause of unexplained arterial and venous thrombosis. Clin Appl Thromb Haemost 1998;4:77.

Chittoor SR , Elsehety AE , Roberts GF , et al. Sticky platele syndrome: A case report and a review of the literature. Clin Appl Thromb Haemost 1999;4:280.

Mammen EF . Ten years’ experience with the“sticky platelet syndrome.” Clin Appl Thromb Haemost 1995;1:66.

Bick RL , Hoppensteadt D . Thrombohemorrhagic defects and recurrent miscarriage syndrome. Blood 2004;104:712a.

Klamroth R , Seibt F , Rimpler H , et al. Reccurent vascular access site thrombosis in patients on hemodialysis—a problem of thrombophilia? Blood 2004;104:300a.

Mammen EF . Sticky platelet syndrome. Semin Thromb Haemost 1999;25:361.

Michelson AD , Furman MI , Goldschmidt-Clermont P , et al. Platelet GP IIIa PLA2 polymorphisms display different sensitivities to agonists. Circulation 2000;101:1013.

Carlsson LE , Greinacher A , Spitzer C , et al. Polymorphisms of the human platelet antigens HPA-1, HPA-2, HPA-3, and HPA-5 on the platelet receptors for fibrinogen (GPIIb/IIIa), von Willebrand factor (GPIb/IX), and collagen (GPIa/IIa) are not correlated with an increased risk for stroke. Stroke 1997;28:1392.

Carter AM , Ossei-Gerning N , Wilson IJ , et al. Association of the platelet PLA polymorphism of glycoprotein IIb/IIIa and the fibrinogen Bß 448 polymorphism with myocardial infarction and extent of coronary artery disease. Circulation 1997;96:1424.

Kastrati A , Schomig A , Seyfarth M , et al. PLA polymorphism of platelet glycoprotein IIIa and risk of restenosis after coronary stent placement. Circulation 1999;99:1005.

Weiss EJ , Bray PF , Tayback M , et al. A polymorphism of a platelet glycoprotein receptor as an inherited risk factor for coronary thrombosis. N Engl J Med 1996;334:1090.

Feng DL , Lindpaintner K , Larson MG , et al. Increased platelet aggregability associated with platelet GPIIIa PLA2 polymorphism: The Framingham Offspring Study. Arterioscler Thromb Vasc Biol 1999;19:1142.

Newman PJ , Derbes RS , Aster RH . The human platelet alloimunogen PLA1 and PLA2 are associated with a leucine 33/proline 33 amino acid polymorphism in membrane glycoprotein IIIa and are distinguishable by DNA typing. J Clin Invest 1989;83:1778.

Renner W , Winkler M , Hoffmann C , et al. The PlA1/A2 polymorphism of platelet glycoprotein IIIa is not associated with deep venous thrombosis. Int Angiol 2001;20:148.

Ridker PM , Hennekens CH , Schmitz C , et al. PIA1/A2 polymorphism of platelet glycoprotein IIIa and risks of myocardial infarction, stroke, and venous thrombosis. Lancet 1997;349:385.