Activin A/Follistatin System: Another Link to Heparin-induced Osteoporosis?

Vale W , Rivier J , Vaughan J , et al. Purification and isolation of an FSH releasing protein from porcine follicular fluid. Nature 1986;321:776.

Robertson DM , Klein R , de Vos FL , et al. The isolation of polypeptides with FSH suppressing activity from bovine follicular fluid which are structurally different to inhibin. Biochem Biophys Res Commun 1987;149:744.

Chen YG , Lui HM , Lin SL , et al. Regulation of cell proliferation, apoptosis, and carcinogenesis by activin. Exp Biol Med 2002;227:75.

Shav-Tal Y , Zipori D. The role of activin A in regulation of hemopoiesis. Stem Cells 2002;20:493.

Phillips DI , Jones KL , Scheerlinck JY , et al. Evidence for activin A and follistatin involvement in the systemic inflammatory response. Mol Cell Endocrinol 2001;180:155.

Molloy CJ , Taylor DS , Pawlowski JE . Novel cardiovascular actions of the activins. J Endocrinol 1999;161:179.

Naumnik B , Borawski J , Myśliwiec M. Activin A/follistatin—new cytokines, new perspectives. Pol Arch Med Wewn 2003;4:431.

Sakai R , Eto Y. Involvement of activin in the regulation of bone metabolism. Mol Cell Endocrinol 2001;180:183.

Sakai R , Fujita S , Ilorie T , et al. Activin increases bone mass and mechanical strength of lumbar vertebrae in aged overiectomized rats. Bone 2000;27:91.

Borawski J , Naumnik B , Myśliwiec M. Hepatocyte growth factor: A possible mediator of heparin-induced osteoporosis? Clin Appl Thromb Hemost 2003;9:171.

Phillips DJ , Jones KL , McGaw DJ , et al. Release of activin and follistatin during cardiovascular procedures is largely due to heparin administration. J Clin Endocrinol Metab 2000;85:2411.

Borawski J , Naumnik B , Myśliwiec M. Activation of hepatocyte growth factor/activin A/follistatin system during hemodialysis: Role of heparin. Kidney Int 2003;64:2229.

Sandset PM , Bendz B , Hansen JB . Physiological function of tissue factor pathway inhibitor and interaction with heparins. Haemostasis 2000;30(Suppl 2):48.

Naumnik B , Borawski J , Myśliwiec M. Different effects of enoxaparin and unfractionated heparin on extrinsic blood coagulation during haemodialysis. Nephrol Dial Transplant 2003;18:1376.