Are the Current Guidelines for the Acceptance of Generic Low Molecular Weight Heparins Adequate?

Abstract

References

1. Fareed J , Kumar A , Walenga JM , Emanuele RM , Williamson K , Hoppensteadt D. Antithrombotic actions and pharmacokinetics of heparin fractions and fragments. Nouv Rev Fr Hematol 1984;26:267-267.

2. Fareed J , Walenga JM , Racanelli A , Hoppensteadt D , Huan X , Messmore HL . Validity of the newly established low-molecular-weight heparin standard in cross-referencing low-molecular-weight heparins. Haemostasis 1988;18(Suppl 3):33-33.

3. Barrett JS , Hainer JW , Kornhauser DM , et al. Anticoagulant pharmacodynamics of tinzaparin following 175 IU/kg subcutaneous administration to healthy volunteers. Thromb Res 2001;101:243-243.

4. Fareed J , Haas S , Sasahara A , eds. Differentiation of low molecular weight heparins. Applied and clinical considerations. Semin Thromb Hemost 1999;25(3):17-17.

5. Fareed J , Walenga JM , Hoppensteadt D , Huan X , Racanelli A. Comparative study on the in vitro and in vivo activities of seven low-molecular-weight heparins. Haemostasis 1988;18(Suppl 3):3-3.

6. Fareed J , Walenga JM , Williamson K , Emanuele RM , Kumar A , Hoppensteadt D. Studies on the antithrombotic effects and pharmacokinetics of heparin fractions and fragments. Semin Thromb Hemost 1985;11 (1):56-56.

7. Memorandum on a provisional International Standard for heparin. Bull WHO 1942;151-151.

8. Barrowcliffe TW , Curtiss AD , Johnson EA , Thomas DP. An internatiuonal standard for low molecular weight heparin. Thromb Haemost 1988;60:1-1.

9. Mulloy B , Gee C , Wheeler SF , Wait R , Gray E , Barrowcliffe TW. Molecular weight measurements of low molecular weight heparins by gel permeation chromatography. Thromb Haemost 1997;77(4):668-668.

10.

10. Cambus JP , Saivin S , Heilmann JJ , Caplain H , Boneu B , Houin G. The pharmacodynamics of tinzaparin in healthy volunteers. Br J Hematol 2002;116:649-649.

11.

11. The Wall Street Journal. Thursday June 12, 2003. Page A3-A3, Vol. CCXLI 114. Bush Acts to Speed Generics to Market (Leila Abboud).