Free accessResearch articleFirst published online 2000-10
Thromboembolic Prophylaxis With Danaparoïd (Orgaran®) in a High-Thrombosis-Risk Pregnant Woman With a History of Heparin-Induced Thrombocytopenia (HIT) and Widal' s Disease
There is no consensus concerning thromboembolic prophylaxis in high-risk pregnant women with a previous his tory of heparin-induced thrombocytopenia. An alternative an ticoagulant therapy is danaparoïd, whereas unfractioned and low-molecular-weight heparin therapy is contraindicated. We report a case of successful thrombosis prophylaxis using dan aparoid in a high-thrombosis-risk pregnant woman with a his tory of heparin-induced thrombocytopenia during a previous pregnancy and Widal's disease.
Warkentin TE , Chong BH, Greinacher A.Heparin-induced thrombocytopenia; towards consensus. Thromb Haemost1998;79:1.
2.
Warkentin TE , Kelton JGA 14-year study of heparin-induced thrombocytopenia . Am J Med1996;101:502.
3.
Greinacher A. , Michels I., Mueller-Eckhardt C.Heparin associated thrombocytopenia: the antibody is not heparin specific. Thromb Haemost1992;67:545.
4.
Magnani HNHeparin-induced thrombocytopenia: an overview of 230 patients treated with Orgaran (Org 10172). Thromb Haemost1993;70:554.
5.
Warkentin TEDanaparoïd (Orgaran®) for the treatment of heparin-induced thrombocytopenia (HIT) and thrombosis: effects on in vivo thrombin and cross-linked fibrin generation, and evaluation of the clinical significance of in vitro cross-reactivity (XR) of Danaparoïd for HIT-IgG. Blood1996;88(suppl 1):626a.
6.
Gill J., Kovacs MJSuccessful use of danaparoid in treatment of heparin-induced thrombocytopenia during twin pregnancy. Obstet Gynecol1997 ;90:648.
7.
Ballem P.Acquired thrombophilia in pregnancy. Semin Thromb Haemost1998;24(suppl 1):41.
8.
Ginsberg JSThromboembolism and pregnancy. Thromb Haemost1999;82:620.
9.
Cadroy Y., Grandjean H., Pichon J., et al.Evaluation of six markers of haemostatic system in normal pregnancy and pregnancy complicated by hypertension or pre-eclampsia. Br J Obstet Gynecol1993;100:416.
10.
Widal F., Abrami P., Lermoyer J.First complete description of the aspirin idiosyncrasy-asthma-nasal polyposis syndrome (plus urticaria)-1922 (with a note on aspirin desensitization). J Asthma1987;24:297.