Review : Evolution of the Motor System: Why the Elephant's Trunk Works Like a Human's Hand

Abstract

The nucleus of Darkschewitsch, the nucleus accessorius medialis of Bechterew, and the parvicellular red nucleus in the mammalian mesodiencephalon fuse with each other and thus have borders that are not always distinct. These structures project topographically to the inferior olive and receive inputs from motor cortex, premotor cortex, substantia nigra, and cerebellar nuclei, which suggests that these nuclei play an important role in mammalian motor control. Furthermore, the nuclei show developmental differences that correspond with species-specialized body parts, such as the human's hand, the axial muscular system of the whale, and the elephant's trunk, to name just a few. We focus here on the differences in these meso diencephalo-olivo-cerebellar projections among certain mammals and propose that these brain structures are altered as the animal's gross anatomy alters. We also suggest that well-developed mesodiencephalo olivo-cerebellar projections may be an important factor for the differentiation of the large neocortex of the human, primate, elephant, and whale during evolutionary progress. NEUROSCIENTIST 5:217-226, 1999