REVIEW ■ : Glial Derived Extracellular Matrix Components: Important Roles in Axon Growth and Guidance

Abstract

Axon growth and guidance, and the correct recognition of distant targets by growth cones rank among the most spectacular achievements of the developing nervous system. The establishment and reformation of adequate networks and the plasticity of synaptic connections are vital for the function and the restoration of the nervous system under conditions of health and disease. Therefore, considerable efforts have been devoted to the elucidation of the molecular and cellular bases of the establishment of interneuronal con nections. It is well established that interactions between neurons and astrocytes are of regulatory importance in this context. Thus, astroglia guides migrating neurons and advancing growth cones to their destination. On the other hand, astrocytes design transient boundaries that deflect axons and segregate groups of neurons, and form scars involved in the inhibition of axonal regeneration after lesion. This duplicity of astroglia is presumably mediated by various gene families. Among these, extracellular matrix (ECM) con stituents seem particularly suited to embody and mediate the ambivalence of astrocytes because these compounds appear to exert either conducive or inhibitory/repulsive effects depending on interacting cell types and conditions. Furthermore, ECM constituents are upregulated by astrocytes upon lesion and con tribute to the construction of glial scars. This review focuses on this class of compounds and their possible functions in the wiring of neural networks. NEUROSCIENTIST 3:371-380, 1997