Long-term potentiation (LTP) is a widely studied form of activity-dependent synaptic plasticity. Hippocampal LTP evoked in the dentate and CA1 areas requires calcium influx through N-methyl-D-aspartate (NMDA) receptor-channel complexes, a process triggered during high-frequency stimulation by conjunctive presy naptic glutamate release and postsynaptic depolarization. It has been suggested that alterations in GABAergic recurrent and/or feedforward inhibitory synaptic transmission may accompany LTP induction in these hippocampal areas. To this end, possible LTP-related modifications in functional inhibition are ad dressed in the context of both paired-pulse depression and the excitatory postsynaptic potential-spike (E-S) relationship. Consideration is also given as to how GABAergic processes may contribute mechanistically to the induction of NMDA receptor-dependent LTP. It is concluded that although GABAergic disinhibition may contribute to the induction of LTP, it is not yet clear whether or not the induction of LTP has a lasting impact on inhibitory processes. NEUROSCIENTIST 3:226-236, 1997
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