Windows of plasticity are fundamental for the correct formation of definitive brain circuits; these periods drive sensory and motor learning during development and ultimately learning and memory in adults. However, establishing windows of plasticity also imposes limitations on the central nervous system in terms of its capacity to recover from injury. Recent evidence highlights the important role that astrocytes and adenosine seem to play in controlling the duration of these critical periods of plasticity.
AckermanSDPérez-CatalánNAFreemanMRDoeCQ. 2021. Astrocytes close a motor circuit critical period. Nature592:414–20.
2.
Andrade-TalaveraYDuque-FeriaPPaulsenORodríguez-MorenoA.2016. Presynaptic spike timing-dependent long-term depression in the mouse hippocampus. Cereb Cortex26:3637–54.
3.
BlissTVCollingridgeGLMorrisRG. 2013. Synaptic plasticity in health and disease: introduction and overview. Philos Trans Royal Soc B36:20130129.
4.
BlundonJABayazitovITZakharenkoSS. 2011. Presynaptic gating of postsynaptically expressed plasticity at mature thalamocortical synapses. J Neurosci31:16012–25.
5.
BlundonJARoyNCTeubnerBJWYuJEomTYSampleKJ, et al. 2017. Restoring auditory cortex plasticity in adult mice by restricting thalamic adenosine signaling. Science356:1352–56.
6.
CajalSR. 1984. The Croonian lecture: la fine structure des centres nerveux. Proc Royal Soc London55:444–68.
7.
ChunSBayazitovITBlundonJAZakharenkoSS. 2013. Thalamocortical long-term potentiation becomes gated after the early critical period in the auditory cortex. J Neurosci33:7345–57.
8.
CrairMCMalenkaRC. 1995. A critical period for long-term potentiation at thalamocortical synapses. Nature375:325–8.
9.
DromerickAWGeedSBarthJBradyKGiannettiMLMitchellA, et al. 2021. Critical Period After Stroke Study (CPASS): a phase II clinical trial testing an optimal time for motor recovery after stroke in humans. Proc Natl Acad Sci U S A118(59):e2026676118.
10.
Falcón-MoyaRPérez-RodríguezMPrius-MengualJAndrade-TalaveraYArroyo-GarcíaLEPérez-ArtésR, et al. 2020. Astrocyte-mediated switch in spike timing-dependent plasticity during hippocampal development. Nat Comm11:4388.
11.
HenschTK. 2004. Critical period regulation. Ann Rev Neurosci27:549–79.
12.
HenschTK. 2005. Critical period plasticity in local cortical circuits. Nat Rev Neurosci6:877–88.
13.
HubelDMWieselTN. 2004. Brain and visual perception: the story of a 25-year collaboration. Oxford (UK): Oxford University Press.
14.
LinneM-LAćimovićJSaudargieneAManninenT.2022. Neuron-glia interactions and brain circuits. Adv Exp Med Biol1359:87–103.
15.
ManninenTSaudargieneALinneM-L.2020. Astrocyte-mediated spike-timing-dependent long-term depression modulates synaptic properties in the developing cortex. PLoS Comput Biol16(11):e1008360.
16.
Martínez-GallegoIPérez-RodríguezMCoatl-CuayaHFloresGRodríguez-MorenoA.2022. Adenosine and astrocytes determine the developmental dynamics of spike timing-dependent plasticity in the somatosensory cortex. J Neurosci42(31):6038–52.
17.
Martínez-GallegoIRodríguez-MorenoAAndrade-TalaveraY.2022. Role of group I metabotropic receptors in spike timing-dependent plasticity. Int J Mol Sci23(14):7807.
18.
Mateos-AparicioPRodríguez-MorenoA.2019. The impact of studying brain plasticity. Front Cell Neurosci13:66.
19.
Pérez-OtañoIRodríguez-MorenoA.2019. Presynaptic NMDARs and astrocytes ally to control circuit-specific information flow. Proc Natl Acad Sci U S A116(27):13166–8.
20.
Pérez-RodríguezMArroyo-GarcíaLEPrius-MengualJAndrade-TalaveraYArmengolJAPérez-VillegasEM, et al. 2019. Adenosine receptor-mediated developmental loss of spike timing-dependent depression in the hippocampus. Cereb Cortex29:3266–81.
21.
RibotJBretonRCalvoCFMoulardJEzanPZapataJ, et al. 2021. Astrocytes close the mouse critical period for visual plasticity. Science373:77–81.
