4. Stat Proteins and Cancer

Darnell JE Jr , Kerr I.M. , Stark G.R. . Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science. 1994; 264: 1415–1421.

Darnell JE Jr . STATs and gene regulation. Science. 1997; 277: 1630–1635.

Akira S. . Functional roles of STAT family proteins: lessons from knockout mice. Stem Cells. 1999; 17: 138–146.

Yu C.L. , Meyer D.J. , Campbell G.S. . Enhanced DNA-binding activity of a Stat3-related protein in cells transformed by the Src oncoprotein. Science. 1995; 269: 81–83.

Bromberg J.F. , Horvath C.M. , Besser D. . Stat3 activation is required for cellular transformation by v-src. Mol Cell Biol. 1998; 18: 2553–2558.

Smith P.D. , Crompton M.R. . Expression of v-src in mammary epithelial cells induces transcription via STAT3. Biochem J. 1998; 331: 381–385.

Turkson J. , Bowman T. , Garcia R. . Stat3 activation by Src induces specific gene regulation and is required for cell transformation. Mol Cell Biol. 1998; 18: 2545–2552.

Besser D. , Bromberg J.F. , Darnell JE Jr . A single amino acid substitution in the v-Eyk intracellular domain results in activation of Stat3 and enhances cellular transformation. Mol Cell Biol. 1999; 19: 1401–1409.

Cao X. , Tay A. , Guy G.R. . Activation and association of Stat3 with Src in v-Src-transformed cell lines. Mol Cell Biol. 1996; 16: 1595–1603.

Carlesso N. , Frank D.A. , Griffin J.D. . Tyrosyl phosphorylation and DNA binding activity of signal transducers and activators of transcription (STAT) proteins in hematopoietic cell lines transformed by Bcr/Abl. J Exp Med. 1996; 183: 811–820.

Chaturvedi P. , Sharma S. , Reddy E.P. . Abrogation of interleukin-3 dependence of myeloid cells by the v-src oncogene requires SH2 and SH3 domains which specify activation of STATs. Mol Cell Biol. 1997; 17: 3295–3304.

Frank D.A. , Varticovski L. . BCR/abl leads to the constitutive activation of Stat proteins, and shares an epitope with tyrosine phosphorylated Stats. Leukemia. 1996; 10: 1724–1730.

Garcia R. , Yu C.L. , Hudnall A. . Constitutive activation of Stat3 in fibroblasts transformed by diverse oncoproteins and in breast carcinoma cells. Cell Growth Differ. 1997; 8: 1267–1276.

Ilaria RL Jr , Van Etten R.A. . P210 and P190(BCR/ABL) induce the tyrosine phosphorylation and DNA binding activity of multiple specific STAT family members. J Biol Chem. 1996; 271: 31704–31710.

Shuai K. , Halpern J. , ten Hoeve J. . Constitutive activation of STAT5 by the BCR-ABL oncogene in chronic myelogenous leukemia. Oncogene. 1996; 13: 247–254.

Zong C.S. , Zeng L. , Jiang Y. . Stat3 plays an important role in oncogenic Ros-and insulin-like growth factor I receptor-induced anchorage-independent growth. J Biol Chem. 1998; 273: 28065–28072.

Garcia R. , Jove R. . Activation of STAT transcription factors in oncogenic tyrosine kinase signaling. J Biomed Sci. 1998; 5: 79–85.

Sartor C.I. , Dziubinski M.L. , Yu C.L. . Role of epidermal growth factor receptor and STAT-3 activation in autonomous proliferation of SUM-102PT human breast cancer cells. Cancer Res. 1997; 57: 978–987.

Watson C.J. , Miller W.R. . Elevated levels of members of the STAT family of transcription factors in breast carcinoma nuclear extracts. Br J Cancer. 1995; 71: 840–844.

Grandis J.R. , Drenning S.D. , Chakraborty A. . Requirement of Stat3 but not Stat1 activation for epidermal growth factor receptor- mediated cell growth in vitro. J Clin Invest. 1998; 102: 1385–1392.

Chai S.K. , Nichols G.L. , Rothman P. . Constitutive activation of JAKs and STATs in BCR-Abl-expressing cell lines and peripheral blood cells derived from leukemic patients. J Immunol. 1997; 159: 4720–4728.

Gouilleux-Gruart V. , Gouilleux F. , Desaint C. . STAT-related transcription factors are constitutively activated in peripheral blood cells from acute leukemia patients. Blood. 1996; 87: 1692–1697.

Hayakawa F. , Towatari M. , Iida H. . Differential constitutive activation between STAT-related proteins and MAP kinase in primary acute myelogenous leukaemia. Br J Haematol. 1998; 101: 521–528.

Liu R.Y. , Fan C. , Garcia R. . Constitutive activation of the JAK2/STAT5 signal transduction pathway correlates with growth factor independence of megakaryocytic leukemic cell lines. Blood. 1999; 93: 2369–2379.

Migone T.S. , Lin J.X. , Cereseto A. . Constitutively activated Jak-STAT pathway in T cells transformed with HTLV-I. Science. 1995; 269: 79–81.

Weber-Nordt R.M. , Egen C. , Wehinger J. . Constitutive activation of STAT proteins in primary lymphoid and myeloid leukemia cells and in Epstein-Barr virus (EBV)-related lymphoma cell lines. Blood. 1996; 88: 809–816.

Lund T.C. , Garcia R. , Medveczky M.M. . Activation of STAT transcription factors by herpesvirus Saimiri Tip-484 requires p56lck. J Virol. 1997; 71: 6677–6682.

Lund T.C. , Prator P.C. , Medveczky M.M. . The Lck binding domain of herpesvirus saimiri tip-484 constitutively activates Lck and STAT3 in T cells. J Virol. 1999; 73: 1689–1694.

Nielsen M. , Kaltoft K. , Nordahl M. . Constitutive activation of a slowly migrating isoform of Stat3 in mycosis fungoides: tyrphostin AG490 inhibits Stat3 activation and growth of mycosis fungoides tumor cell lines. Proc Natl Acad Sci U S A. 1997; 94: 6764–6769.

Sun W.H. , Pabon C. , Alsayed Y. . Interferon-alpha resistance in a cutaneous T-cell lymphoma cell line is associated with lack of STAT1 expression. Blood. 1998; 91: 570–576.

Yu C.L. , Jove R. , Burakoff S.J. . Constitutive activation of the Janus kinase-STAT pathway in T lymphoma overexpressing the Lck protein tyrosine kinase. J Immunol. 1997; 159: 5206–5210.

Zhang Q. , Nowak I. , Vonderheid E.C. . Activation of Jak/STAT proteins involved in signal transduction pathway mediated by receptor for interleukin 2 in malignant T lymphocytes derived from cutaneous anaplastic large T-cell lymphoma and Sezary syndrome. Proc Natl Acad Sci U S A. 1996; 93: 9148–9153.

Catlett-Falcone R. , Landowski T.H. , Oshiro M.M. . Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells. Immunity. 1999; 10: 105–115.

Bromberg J.F. , Wrzeszczynska M.H. , Devgan G. . Stat3 as an oncogene. Cell. 1999; 98: 295–303.