Tumors arising from the renal tubular epithelium have variable characteristics and have been subject to a variety of histologic classifications.
Methods
The authors describe the distinct clinical, pathologic, phenotypic, and genotypic features of different types of renal tumors.
Results
The Mainz classification is now widely accepted because characteristic genetic alterations have been demonstrated in each tumor type.
Conclusions
The increasing emphasis on utilizing genetic characteristics of specific tumors is reflected by the more widespread use of the Mainz classification for renal cell tumors.
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