Anemia produces deleterious effects in the older patient with cancer and corresponds with an increasing prevalence of comorbid conditions. Erythropoietin can improve anemia of chronic disease, the most common form of anemia in the elderly.
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References
1.
GlaspyJ., BukowskiR., SteinbergD.. Impact of therapy with epoetin alfa on clinical outcomes in patients with nonmyeloid malignancies during cancer chemotherapy in community oncology practice.J Clin Oncol.1997; 15: 1218–1234.
2.
CellaD.. (FACT-An) scale: a new tool for the assessment of outcome in cancer anemia and fatigue.Semin Hematol.1997; 34: 13–19.
3.
BalducciL., LymanG.H.. Cancer in the elderly: epidemiologic and clinical implications.Clin Geriatr Med.1997; 13: 1–14.
MoscinskiL.. The aging bone marrow. In: BalducciL., LymanG.H., ErshlerW.B., eds. Comprehensive Geriatric Oncology.London, England: Harwood Academic Publishers. Hardwood Press.1998: 413–420.
9.
ChattaG.S., PriceT.H., AllenR.C.. Effects of in vivo recombinant methionyl human granulocyte colony-stimulating factor on the neutrophil response and peripheral blood colony-forming cells in healthy young and elderly adult volunteers.Blood.1994; 84: 2923–2929.
10.
HyrotaY., OkamuraS., KimuraN.. Hematopoiesis in the aged as studied by “in vitro” colony assay.Eur J Haematol.1988; 40: 83–90.
11.
MorraL., MocciaF., MazzarelloG.P.. Defective burst-promoting activity of T lymphocytes from anemic and non-anemic elderly people.Ann Hematol.1994; 68: 67–71.
12.
JoostenE., Van HoveL., LesaffreE.. Serum erythropoietin levels in elderly inpatients with anemia of chronic disorders and iron deficiency anemia.J Am Geriatr Soc.1993; 41: 1301–1304.
13.
NafzigerJ., PaillaK., LucianiL.. Decreased erythropoietin responsiveness to iron deficiency anemia in the elderly.Am J Hematol.1993; 43: 172–176.
14.
MatsuoT., KarioK., KodomaK.. An inappropriate erythropoietic response to iron deficiency anemia in the elderly.Clin Lab Hematol.1995; 17: 317–321.
TasakiT., OhtoH., NoguchiM.. Iron and erythropoietin measurements in autologous blood donors with anemia: implications for management.Transfusion.1994; 34: 337–343.
17.
GoodnoughL.T., PriceT.H., ParvinC.A.. The endogenous erythropoietin response and the erythropoietic response to blood loss anemia: the effects of age and gender.J Lab Clin Med.1995; 126: 57–64.
18.
CascinuS., Del FerroE., FedeliA.. Recombinant human erythropoietin treatment in elderly cancer patients with cisplatin-associated anemia.Oncology.1995; 52: 422–426.
19.
BaldwinJ.G.. Hematopoietic function in the elderly.Arch Intern Med.1988; 148: 2544–2546.
20.
InelmenI.M., D'AlessioM., GattoM.R.. Descriptive analysis of the prevalence of anemia in a randomly selected sample of elderly people living at home: some results of an Italian multicentric study.Aging.1994; 6: 81–89.
21.
AniaB.J., SumanV.J., FairbanksV.F.. Prevalence of anemia in medical practice: community versus referral patients.Mayo Clinic Proc.1994; 69: 730–735.
22.
AniaB.J., SumanV.J., FairbanksV.F.. Incidence of anemia in older people: an epidemiologic study of a well defined population.J Am Geriatr Soc.1997; 45: 825–831.
23.
KirkebyO.J., FossumS., RisoeC.. Anemia in elderly patients: incidence and causes of low hemoglobin concentration in a city general practice.Scand J Prim Health Care.1991; 9: 167–171.
24.
Nilsson-EhleH., JagenburgR., LandahlS.. Haematological abnormalities and reference intervals in the elderly: a cross-sectional comparative study of three urban Swedish population samples aged 70, 75 and 81 years.Acta Med Scand.1988; 224: 595–604.
25.
SahadevanS., ChooP.W., JayaratnamF.J.. Anaemia in hospitalised elderly.Singapore Med J.1995; 36: 375–378.
26.
CarmelR.. Prevalence of undiagnosed pernicious anemia in the elderly.Arch Intern Med.1996; 156: 1097–1100.
27.
AnttilaP., IhalainenJ., SaloA.. Idiopathic macrocytic anemia in the aged: molecular and cytogenetic findings.Br J Haematol.1995; 90: 797–803.
28.
CarpenterM.A., KendallR.G., O'BrienA.E.. Reduced erythropoietin response to anaemia in elderly patients with normocytic anaemia.Eur J Haematol.1992; 49: 119–121.
29.
JoostenE., Van HoveL., LeSaffreE.. Serum erythropoietin levels in elderly inpatients with anemia of chronic disorders or iron deficiency anemia.J Am Geriatr Soc.1993; 41: 1401–1304.
30.
NormanE.J., MorrisonJ.A.. Screening elderly populations for cobalamin (vitamin B-12) deficiency using urinary methylmalonic acid assay by gas chromatography mass spectrometry.Am J Med.1993; 94: 589–593.
31.
PennypackerL.C., AllenR.H., KellyJ.P.. High prevalence of cobalamine deficiency in elderly outpatients.J Am Geriatr Soc.1992; 40: 1197–1204.
32.
SumnerA.E., ChinM.M., AbrahmJ.L.. Elevated methylmalonic acid and total homocysteine levels show high prevalence of vitamin B12 deficiency after gastric surgery.Ann Intern Med.1996; 124: 469–476.
33.
HerzlichB., HerbertV.. Depletion of serum holotranscobalamin II: an early sign of negative vitamin B12 balance.Lab Invest.1988; 58: 332–337.
34.
JoostenE., PelemansW., DevosP.. Cobalamin absorption and serum homocysteine and methylmalonic acid in elderly subjects with low serum cobalamin.Eur J Haematol.1993; 51: 25–30.
35.
GuayattG.H., PattersonC., AliM.. Diagnosis of iron-deficiency anemia in the elderly.Am J Med.1990; 88: 205–209.
36.
SmiejaM.J., CookD.J., HuntD.L.. Recognizing and investigating iron-deficiency anemia in hospitalized elderly people.Can Med Assoc J.1966; 155: 691–696.
BiaggioniI., RobertsonD., KrantzS.. The anemia of primary autonomic failure and its reversal with recombinant erythropoietin.Ann Intern Med.1994; 121: 181–186.
39.
KrantzS.B.. Pathogenesis and treatment of the anemia of chronic disease.Am J Med Sci.1994; 307: 353–359.
40.
Del MastroL., VenturiniM., LionettoR.. Randomized phase III trial evaluating the role of erythropoietin in the prevention of chemotherapy-induced anemia.J Clin Oncol.1997; 15: 2715–2721.
41.
DaltonW.. Personal communication. Symposium: Anemia in Cancer Patients: Current Understanding and Management. Key West, Florida, October 17-18, 1997.