Akt Goes Cycling

Manning B.D. , Cantley L.C. . AKT/PKB signaling: navigating downstream. Cell. 2007; 129(7): 1261–1274.

Bellacosa A. , Kumar C.C. , Di Cristofano A. . Activation of AKT kinases in cancer: implications for therapeutic targeting. Adv Cancer Res. 2005; 94: 29–86.

Vivanco I. , Sawyers C.L. . The phosphatidylinositol 3-kinase AKT pathway in human cancer. Nat Rev Cancer. 2002; 2(7): 489–501.

Mahajan K. , Coppola D. , Challa S. . Ack1 mediated AKT/PKB tyrosine 176 phosphorylation regulates its activation. PLoS One. 2010; 5(3): e9646.

Mahajan K. , Mahajan N.P. . PI3K-independent AKT activation in cancers: a treasure trove for novel therapeutics. J Cell Physiol. 2012; 227(9): 3178–3184.

Franke T.F. , Yang S.I. , Chan T.O. . The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase. Cell. 1995; 81(5): 727–736.

Burgering B.M. , Coffer P.J. . Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction. Nature. 1995; 376(6541): 599–602.

Stephens L. , Anderson K. , Stokoe D. . Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B. Science. 1998; 279(5351): 710–714.

Stokoe D. , Stephens L.R. , Copeland T. . Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B. Science. 1997; 277(5325): 567–570.

Sarbassov D.D. , Guertin D.A. , Ali S.M. . Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science. 2005; 307(5712): 1098–1101.

Joung S.M. , Park Z.Y. , Rani S. . Akt contributes to activation of the TRIF-dependent signaling pathways of TLRs by interacting with TANK-binding kinase 1. J Immunol. 2011; 186(1): 499–507.

Liu P. , Begley M. , Michowski W. . Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus. Nature. 2014; 508(7497): 541–545.

Guo J.P. , Coppola D. , Cheng J.Q. . IKBKE protein activates Akt independent of phosphatidylinositol 3-kinase/PDK1/mTORC2 and the pleckstrin homology domain to sustain malignant transformation. J Biol Chem. 2011; 286(43): 37389–37398.

Xie X. , Zhang D. , Zhao B. . IkappaB kinase epsilon and TANK-binding kinase 1 activate AKT by direct phosphorylation. Proc Natl Acad Sci USA. 2011; 108(16): 6474–6479.

Mahajan K. , Coppola D. , Chen Y.A. . Ack1 tyrosine kinase activation correlates with pancreatic cancer progression. Am J Pathol. 2012; 180(4): 1386–1393.

Chen R. , Kim O. , Yang J. . Regulation of Akt/PKB activation by tyrosine phosphorylation. J Biol Chem. 2001; 276(34): 31858–31862.

Zheng Y. , Peng M. , Wang Z. . Protein tyrosine kinase 6 directly phosphorylates AKT and promotes AKT activation in response to epidermal growth factor. Mol Cell Biol. 2010; 30(17): 4280–4292.

Gallorini M. , Cataldi A. , di Giacomo V. . Cyclin-dependent kinase modulators and cancer therapy. BioDrugs. 2012; 26(6): 377–391.

Hirai H. , Sootome H. , Nakatsuru Y. . MK-2206, an allosteric Akt inhibitor, enhances antitumor efficacy by standard chemotherapeutic agents or molecular targeted drugs in vitro and in vivo. Mol Cancer Ther. 2010; 9(7): 1956–1967.