Catheter-Related Bloodstream Infections,Part I: Pathogenesis,Diagnosis,and Management

Gross P.A. , Barrett T.L. , Dellinger P.E. . Purpose of quality standards for infectious diseases. Infectious Diseases Society of America. Clin Infect Dis. 1994; 18: 421.

Maki D.G. , Mermel L.A. . Infections due to infusion therapy. In: Bennett J.V. , Brachman P.S. , eds. Hospital Infections. Philadelphia, Pa: Lippincott-Raven; 1998.

Pearson M.L. . Guideline for prevention of intravascular device-related infections. Hospital Infection Control Practices Advisory Committee. Infect Control Hosp Epidemiol. 1996; 17: 438–473.

Jarvis W.R. , Edwards J.E. , Culver D.H. . Nosocomial infection rates in adult and pediatric intensive care units in the United States. Am J Med. 1991; 91(suppl 3B): 185S–191S.

Mayhall C.G. . Diagnosis and management of infections of implantable devices used for prolonged venous access. Curr Clin Top Infect Dis. 1992; 12: 83–110.

Pittet D. , Tarara D. , Wenzel R.P. . Nosocomial bloodstream infection in critically ill patients: excess length of stay, extra costs, and attributable mortality. JAMA. 1994; 271: 1598–1601.

Heiselman D. . Nosocomial bloodstream infections in the critically ill. JAMA. 1994; 272: 1819–1820.

Edgeworth J.D. , Treacher D.F. , Eykyn S.J. . A 25-year study of nosocomial bacteremia in an adult intensive care unit. Crit Care Med. 1999; 27: 1421–1428.

Maki D.G. , Stolz S.M. , Wheeler S. . Prevention of central venous catheter–related bloodstream infection by use of an antiseptic-impregnated catheter. A randomized, controlled trial. Ann Intern Med. 1997; 127: 257–266.

Mermel L.A. , McCormick R.D. , Springman S.R. . The pathogenesis and epidemiology of catheter-related infection with pulmonary artery Swan-Ganz catheters: a prospective study utilizing molecular sub-typing. Am J Med. 1991; 91: 197S–205S.

Raad I. , Costerton W. , Sabharwal U. . Ultrastructural analysis of indwelling vascular catheters: a quantitative relationship between luminal colonization and duration of placement. J Infect Dis. 1993; 168: 400–407.

Lopes J.D. , dos Reis M. , Brentani R.R. . Presence of laminin receptors in Staphylococcus aureus. Science. 1985; 229: 275–277.

Herrmann M. , Suchard S.J. , Boxer L.A. . Thrombospondin binds to Staphylococcus aureus and promotes staphylococcal adherence to surfaces. Infect Immun. 1991; 59: 279–288.

Herrmann M. , Vaudaux P.E. , Pittet D. . Fibronectin, fibrinogen, and laminin act as mediators of adherence of clinical staphylococcal isolates to foreign material. J Infect Dis. 1988; 158: 693–701.

Vaudaux P. , Pittet D. , Haeberli A. . Fibronectin is more active than fibrin or fibrinogen in promoting Staphylococcus aureus adherence to inserted intravascular catheters. J Infect Dis. 1993; 167: 633–641.

Nilsson M. , Frykberg L. , Flock J.I. . A fibrinogen-binding protein of Staphylococcus epidermidis. Infect Immun. 1998; 66: 2666–2673.

Hanna H.A. , Raad I. . Blood products: a significant risk factor for long-term catheter-related bloodstream infections in cancer patients. Infect Control Hosp Epidemiol. 2001; 22: 165–166.

Mermel L.A. . Bacteriology, safety and prevention of infection associated with continuous intravenous infusions. Blood Coagul Fibrinolysis. 1996; 7(suppl 1): S45–S51.

Kiehn T.E. , Armstrong D. . Changes in the spectrum of organisms causing bacteremia and fungemia in immunocompromised patients due to venous access devices. Eur J Clin Microbiol Infect Dis. 1990; 9: 869–872.

Kristinsson K.G. . Diagnosis of catheter-related infections. In: Seifert H. , Jansen B. , Farr B.M. , eds. Catheter-Related Infections. New York, NY: M Dekker; 1997.

Cooper G.L. , Hopkins C.C. . Rapid diagnosis of intravascular catheter-associated infection by direct gram staining of catheter segments. N Engl J Med. 1985; 312: 1142–1147.

Kite P. , Dobbins B.M. , Wilcox M.H. . Rapid diagnosis of central-venous-catheter-related bloodstream infection without catheter removal. Lancet. 1999; 354: 1504–1507.

Maki D.G. , Weise C.E. , Sarafin H.W. . A semiquantitative culture method for identifying intravenous-catheter-related infection. N Engl J Med. 1977; 296: 1305–1309.

Cleri D.J. , Corrado M.L. , Seligman S.J. . Quantitative culture of intravenous catheters and other intravascular inserts. J Infect Dis. 1980; 141: 781–786.

Brun-Buisson C. , Abrouk F. , Legrand P. . Diagnosis of central venous catheter-related sepsis. Critical level of quantitative tip cultures. Arch Intern Med. 1987; 147: 873–877.

Schmitt S.K. , Knapp C. , Hall G.S. . Impact of chlorhexidine-silver sulfadiazine-impregnated central venous catheters on in vitro quantitation of catheter-associated bacteria. J Clin Microbiol. 1996; 34: 508–511.

Bouza E. , Burillo A. , Munoz P. . Catheter-related infections: diagnosis and intravascular treatment. Clin Microbiol Infect. 2002; 8: 265–274.

Sherertz R.J. , Raad I.I. , Belani A. . Three-year experience with sonicated vascular catheter cultures in a clinical microbiology laboratory. J Clin Microbiol. 1990; 28: 76–82.

Heard S.O. , Wagle M. , Vijayakumar E. . Influence of triple-lumen central venous catheters coated with chlorhexidine and silver sulfadiazine on the incidence of catheter-related bacteremia. Arch Intern Med. 1998; 158: 81–87.

Widmer A.F. , Nettleman M. , Flint K. . The clinical impact of culturing central venous catheters. A prospective study. Arch Intern Med. 1992; 152: 1299–1302.

DesJardin J.A. , Falagas M.E. , Ruthazer R. . Clinical utility of blood cultures drawn from indwelling central venous catheters in hospitalized patients with cancer. Ann Intern Med. 1999; 131: 641–647.

Fan S.T. , Teoh-Chan C.H. , Lau K.F. . Evaluation of central venous catheter sepsis by differential quantitative blood culture. Eur J Clin Microbiol Infect Dis. 1989; 8: 142–144.

Capdevila J.A. , Planes A.M. , Polomar M. . Value of differential quantitative blood cultures in the diagnosis of catheter-related sepsis. Eur J Clin Microbiol Infect Dis. 1992; 11: 403–407.

Kite P. , Dobbins B.M. , Wilcox M.H. . Evaluation of a novel endoluminal brush method for in situ diagnosis of catheter-related sepsis. J Clin Pathol. 1997; 50: 278–282.

Blot F. , Schmidt E. , Nitenberg G. . Earlier positivity of central-venous-versus peripheral-blood cultures is highly predictive of catheter-related sepsis. J Clin Microbiol. 1998; 36: 105–109.

Blot F. , Nitenberg G. , Chachaty E. . Diagnosis of catheter-related bacteraemia: a prospective comparison of the time to positivity of hub-blood versus peripheral-blood cultures. Lancet. 1999; 354: 1071–1077.

Whitman E.D. , Boatman A.M. . Comparison of diagnostic specimens and methods to evaluate infected venous access ports. Am J Surg. 1995; 170: 665–670.

Douard M.C. , Arlet G. , Longuet P. . Diagnosis of venous access port related infections. Clin Infect Dis. 1999; 29: 1197–1202.

Fidalgo S. , Vazquez F. , Mendoza M.C. . Bacteremia due to Staphylococcus epidermidis: microbiologic, epidemiologic, clinical, and prognostic features. Rev Infect Dis. 1990; 12: 520–528.

Pollack P.F. , Kadden M. , Byrne W.J. . 100 patient years’ experience with the Broviac silastic catheter for central venous nutrition. JPEN J Parenter Enteral Nutr. 1981; 5: 32–36.

Herrmann M. , Peters G. . Catheter-associated infections caused by coagulase-negative staphylococci: clinical and biological aspects. In: Seifert H. , Jansen B. , Farr B.M. , eds. Catheter-Related Infections. New York, NY: M Dekker; 1997.

Raad I. , Davis S. , Khan A. . Impact of central venous catheter removal on the recurrence of catheter-related coagulase-negative staphylococci bacteremia. Infect Control Hosp Epidemiol. 1992; 13: 215–221.

Raad I.I. , Sabbagh M.F. . Optimal duration of therapy for catheter-related Staphylococcus aureus bacteremia: a study of 55 cases and review. Clin Infect Dis. 1992; 14: 75–82.

Raad I. , Narro J. , Khan A. . Serious complications of vascular catheter-related Staphylococcus aureus bacteremia in cancer patients. Eur J Clin Microbiol Infect Dis. 1992; 11: 675–682.

Malanoski G.J. , Samore M.H. , Pefanis A. . Staphylococcus aureus catheter-associated bacteremia. Minimal effective therapy and unusual infectious complications associated with arterial sheath catheters. Arch Intern Med. 1995; 155: 1161–1166.

Greene J.N. . Infections related to vascular access devices. Cancer Control. 1996; 3: 456–464.

Rosen A.B. , Fowler V.G. Jr. , Corey G.R. . Cost-effectiveness of transesophageal echocardiography to determine the duration of therapy for intravascular catheter-associated Staphylococcus aureus bacteremia. Ann Intern Med. 1999; 130: 810–820.

Krywda E. , Gotoff R. , Andris D. . Antibiotic lock treatment (ALT): impact on catheter salvage and cost savings. In: Program and Abstracts of the 35th Interscience Conference of Antimicrobial Agents and Chemotherapy. San Francisco, Calif; 1995: AJ4. Abstract.

Guedon C. , Nouvellon M. , Lalaude O. . Efficacy of antibiotic-lock technique with teicoplanin in staphylococcus epidermidis catheter-related sepsis during long-term parenteral nutrition. JPEN J Parenter Enteral Nutr. 2002; 26: 109–113.

Strinden W.D. , Helgerson R.B. , Maki D.G. . Candida septic thrombosis of the great central veins associated with central catheters. Clinical features and management. Ann Surg. 1985; 202: 653–658.

Raviglione M.C. , Battan R. , Pablos-Mendez A. . Infections associated with Hickman catheters in patients with acquired immunodeficiency syndrome. Am J Med. 1989; 86(pt 2): 780–786.

Gold H.S. , Karchmer A.W. . Catheter-associated Staphylococcus aureus bacteremia. Hosp Pract (Off Ed). 1996; 31: 133–137, 142-144, 150.

Lecciones J.A. , Lee J.W. , Navarro E.E. . Vascular catheter-associated fungemia in patients with cancer: analysis of 155 episodes. Clin Infect Dis. 1992; 14: 875–883.

Ashby M.J. , Neale J.E. , Knott S.J. . Effect of antibiotics on non-growing planktonic cells and biofilms of Escherichia coli. J Antimicrob Chemother. 1994; 33: 443–452.

Strinden W.D. , Helgerson R.B. , Maki D.G. . Candida septic thrombosis of the great central veins associated with central catheters. Ann Surg. 1985; 202: 653–658.

Dugdale D.C. , Ramsey P.G. . Staphylococcus aureus bacteremia in patients with Hickman catheters. Am J Med. 1990; 89: 137–141.

Gill M.V. , Klein N.C. , Cunha B.A. . Unusual organisms causing intravenous line infections in compromised hosts. I. Bacterial and algal infections. Infect Dis Clin Pract. 1996; 5: 244–255.

Raad I. , Bompart F. , Hachem R. . Prospective, randomized dose-ranging open phase II pilot study of quinupristin/dalfopristin versus vancomycin in the treatment of catheter-related staphylococcal bacteremia. Eur J Clin Microbiol Infect Dis. 1999; 18: 199–202.

Garcia R. , Raad I. . In vitro study of the potential role of quinupristin/dalfopristin in the treatment of catheter-related staphylococcal infections. Eur J Clin Microbiol Infect Dis. 1996; 15: 933–936.

Moellering R.C. Jr. . A novel antimicrobial agent joins the battle against resistant bacteria. Ann Intern Med. 1999; 130: 155–157.

Mermel L.A. , Farr B.M. , Sherertz R.J. . Guidelines for the management of intravascular catheter-related infections. J Intraven Nurs. 2001; 24: 180–205.

Steinberg J.P. , Clark C.C. , Hackman B.O. . Nosocomial and community-acquired Staphylococcus aureus bacteremias from 1980 to 1993: impact of intravascular devices and methicillin resistance. Clin Infect Dis. 1996; 23: 255–259.

Zeylemaker M.M. , Jaspers C.A. , van Kraaij M.G. . Long-term infectious complications and their relation to treatment duration in catheter-related Staphylococcus aureus bacteremia. Eur J Clin Microbiol Infect Dis. 2001; 20: 380–384.

Meunier F. . Management of candidemia. N Engl J Med. 1994; 331: 1371–1372.

Anaissie E.J. , Vartivarian S.E. , Abi-Said D. . Fluconazole versus amphotericin B in the treatment of hematogenous candidiasis: a matched cohort study. Am J Med. 1996; 101: 170–176.

Pfaller M.A. , Barry A.L. . In vitro susceptibilities of clinical yeast isolates to three antifungal agents determined by the microdilution method. Mycopathologia. 1995; 130: 3–9.

Berrouane Y.F. , Hollis R.J. , Pfaller M.A. . Strain variation among and antifungal susceptibilities of isolates of Candida krusei. J Clin Microbiol. 1996; 34: 1856–1858.

Rex J.H. , Walsh T.J. , Sobel J.D. . Practice guidelines for the treatment of candidiasis. Infectious Diseases Society of America. Clin Infect Dis. 2000; 30: 662–678.

Rex J.H. , Bennett J.E. , Sugar A.M. . A randomized trial comparing fluconazole with amphotericin B for the treatment of candidemia in patients without neutropenia. Candidemia Study Group and the National Institute. N Engl J Med. 1994; 331: 1325–1330.

Mermel L.A. , Farr B.M. , Sherertz R.J. . Guidelines for the management of intravascular catheter-related infections. Clin Infect Dis. 2001; 32: 1249–1272.

Pettigrew R.A. , Lang S.D. , Haydock D.A. . Catheter-related sepsis in patients on intravenous nutrition: a prospective study of quantitative catheter cultures and guidewire changes for suspected sepsis. Br J Surg. 1985; 72: 52–55.

Raad I. , Davis S. , Khan A. . Impact of central venous catheter removal on the recurrence of catheter-related coagulase-negative staphylococcal bacteremia. Infect Control Hosp Epidemiol. 1992; 13: 215–221.

Li J.S. , Sexton D.J. , Mick N. . Proposed modifications to the Duke criteria for the diagnosis of infective endocarditis. Clin Infect Dis. 2000; 30: 633–638.

Hartstein A.I. , Mulligan M.E. , Morthland V.H. . Recurrent Staphylococcus aureus bacteremia. J Clin Microbiol. 1992; 30: 670–674.

Rosen A.B. , Fowler V.G. Jr. , Corey G.R. . Cost-effectiveness of transesophageal echocardiography to determine the duration of therapy for intravascular catheter-associated Staphylococcus aureus bacteremia. Ann Intern Med. 1999; 130: 810–820.

Peacock S.J. , Eddleston M. , Emptage A. . Positive intravenous line tip cultures as predictors of bacteremia. J Hosp Infect. 1998; 40: 35–38.

Arnow P.M. , Quimosing E.M. , Beach M. . Consequences of intravascular catheter sepsis. Clin Infect Dis. 1993; 16: 778–784.

Hogevik H. , Alestig K. . Fungal endocarditis: a report on seven cases and a brief review. Infection. 1996; 24: 17–21.

Garrison P.K. , Freedman L.R. . Experimental endocarditis I. Staphylococcal endocarditis in rabbits resulting from placement of a polyethylene catheter in the right side of the heart. Yale J Biol Med. 1970; 42: 394–410.

Widmer A.F. , Nettleman M. , Flint K. . The clinical impact of culturing central venous catheters. A prospective study. Arch Intern Med. 1992; 152: 1299–1302.

Malanoski G.J. , Samore M.H. , Pefanis A. . Staphylococcus aureus catheter-associated bacteremia. Minimal effective therapy and unusual infectious complications associated with arterial sheath catheters. Arch Intern Med. 1995; 155: 1161–1166.

Kentos A. , Dufaye P. , Jacobs F. . Candida albicans septic thrombosis of the right atrium is associated with a central venous catheter. Clin Infect Dis. 1995; 21: 440–442.

Walsh T.J. , Bustamente C.I. , Vlahov D. . Candidal suppurative peripheral thrombophlebitis: recognition, prevention, and management. Infect Control. 1986; 7: 16–22.

Maki D.G. , McCormick R.D. , Uman S.J. . Septic endarteritis due to intra-arterial catheters for cancer chemotherapy. I. Evaluation of an outbreak. II. Risk factors, clinical features and management. III. Guidelines for prevention. Cancer. 1979; 44: 1228–1240.

Falk P.S. , Scuderi P.E. , Sherertz R.J. . Infected radial artery pseudoaneurysms occurring after percutaneous cannulation. Chest. 1992; 101: 490–495.

Benoit D. , Decruyenaere J. , Vandewoude K. . Management of candidal thrombophlebitis of the central veins: case report and review. Clin Infect Dis. 1998; 26: 393–397.

Prince A. , Heller B. , Levy J. . Management of fever in patients with central vein catheters. Pediatr Infect Dis. 1986; 5: 20–24.

Wilson W.R. , Karchmer A.W. , Dajani A.S. . Antibiotic treatment of adults with infective endocarditis due to streptococci, enterococci, staphylococci, and HACEK microorganisms American Heart Association. JAMA. 1995; 274: 1706–1713.