HamermanD.Toward an understanding of frailty. Ann Intern Med.1999; 130: 945–950.
2.
CasselC.K.Money, medicine, and Methuselah. Mt Sinai J Med.1998; 65: 237–245.
3.
DuthieE.H.Physiology of aging: relevance to symptoms, perceptions, and treatment tolerance. In: BalducciL., LymanG.H., ErshlerW.B., eds. Comprehensive Geriatric Oncology.Amsterdam, The Netherlands: Harwood Academic Publ; 1998: 247–262.
4.
ExtermannM., OvercashJ., LymanG.H.Comorbidity and functional status are independent in older cancer patients. J Clin Oncol.1998; 16: 1582–1587.
5.
BalducciL., StantaG.Cancer in the frail patient: a coming epidemic. Hematol Oncol Clin North Am.2000; 14: 235–250. Review.
6.
ReubenD.B., RubensteinL.V., HirschS.H.Value of functional status as predictor of mortality: results of a prospective study. Am J Med.1992; 93: 663–669.
7.
MantonK.G.A longitudinal study of functional change and mortality in the United States. J Gerontol.1988; 43: S153–S161.
8.
InouyeS.K., PeduzziP.N., RobisonJ.T.Importance of functional measures in predicting mortality among older hospitalized patients. JAMA.1998; 279: 1187–1193.
9.
SatarianoW.A., RaglandD.R.The effect of comorbidity on 3-year survival of women with primary breast cancer. Ann Intern Med.1994; 120: 104–110.
10.
PiccirilloJ.F.Inclusion of comorbidity in a staging system for head and neck cancer. Oncology (Huntingt).1995; 831–836; discussion 841,845–848.
11.
NewschafferC.J., BushT.L., PenberthyL.E.Does comorbid disease interact with cancer? An epidemiological analysis of mortality in a cohort of elderly breast cancer patients. J Gerontol A Biol Sci Med Sci.1998; 53A: M372–378.
12.
ExtermannM.Assessment of the older cancer patient. Hematol Oncol Clin North Am.2000; 14: 63–77.
13.
EaglesJ.M., BeattieJ.A.G., RestallD.B.Relationship between cognitive impairment and early a death in the elderly. Br Med J.1990; 300: 239–240.
14.
FlackerJ.M., KielyD.K.A practical approach to identifying mortality-related factors in established long-term care residents. J Am Geriatr Soc.1998; 46: 1012–1015.
15.
WinogradC.H., GeretyM.B., ChungM.Screening for frailty: criteria and predictors of outcomes. J Am Geriatr Soc.1991; 39: 778–784.
16.
CovinskyK.E., KahanaE., ChinM.H.Depressive symptoms and 3-year mortality in older hospitalized medical patients. Ann Intern Med.1999; 130: 563–569.
17.
TinettiM.E., WilliamsC.S.The effect of falls and fall injuries on functioning in community-dwelling older persons. J Gerontol A Biol Sci Med Sci.1998; 53: M112–M119.
18.
InouyeS.K., BogardusS.T.Jr, CharpentierP.A.A multicomponent intervention to prevent delirium in hospitalized older patients. N Engl J Med.1999; 340: 669–676.
19.
RockwoodK., StadnykK., MacknightC.A brief clinical instrument to classify frailty in elderly people. Lancet.1999; 353: 205–206.
20.
MendoncaJ.D., VelamoorV.R., SauveD.Key features of maltreatment of the infirm elderly in home settings. Can J Psychiatry.1996; 41: 107–113.
21.
BalducciL., ExtermannM.Cancer and aging: an evolving panorama. Hematol Oncol Clin North Am.2000; 14: 1–16.
22.
NarainP., RubensteinL.Z., WielandG.D.Predictors of immediate and 6-month outcome in hospitalized elderly patients: the importance of functional status. J Am Geriatr Soc.1988; 36: 775–783.
23.
Barberger-GateauP., FabrigouleC., HelmerC.Functional impairment in instrumental activities of daily living: an early clinical sign of dementia?J Am Geriatr Soc.1999; 47: 456–462.
24.
MonfardiniS., FerrucciL., FratinoL.Validation of a multidimensional evaluation scale for use in elderly cancer patients. Cancer.1996; 77: 395–401.
25.
PaolissoG., TagliamonteM.R., RizzoM.R.Oxidative stress and advancing age: results in healthy centenarians. J Am Geriatr Soc.1998; 46: 833–838.
26.
StantaG.Morbid anatomy of aging. In: BalducciL., LymanG.H., ErshlerW.B., eds. Comprehensive Geriatric Oncology.Amsterdam, The Netherlands: Harwood Academic Publ; 1998: 229–235.
27.
CovaD., BerettaG., BalducciL.Cancer chemotherapy in the older person. In: BalducciL., LymanG.H., ErshlerW.B., eds. Comprehensive Geriatric Oncology.Amsterdam, The Netherlands: Harwood Academic Publ; 1998: 429–442.
28.
JitapunkulS., HarwoodR.Plasma osmolality and survival of elderly continuing-care patients. Age Ageing.1990; 19: 346–347.
29.
RinkL., CakmanI., KirchnerH.Altered cytokine production in the elderly. Mech Ageing Dev.1998; 102: 199–209.
30.
HackV., BreitkreutzR., KinscherfR.The redox state as a correlate of senescence and wasting and as a target for therapeutic intervention. Blood.1998; 59–67.
31.
JetteA.M., JetteD.U., NgJ.Are performance-based measures sufficiently reliable for use in multicenter trials?J Gerontol A Biol Sci Med Sci.1999; 54: M3–6.
32.
ExtermannM.Acute leukemia in the elderly. Clin Geriatr Med.1997; 13: 227–244.
33.
BuchnerT.Treatment of acute myeloid leukemia in the older patient. In: BalducciL., LymanG.H., ErshlerW.B., eds. Comprehensive Geriatric Oncology.Amsterdam, The Netherlands: Harwood Academic Publ; 1998: 545–550.
34.
O'ReillyS.E., ConnorsJ.M., MacphersonN.Malignant lymphomas in the elderly. Clin Geriatr Med.1997; 13: 251–264.
35.
ThigpenJ.T.Ovarian cancer in the older patient. In: BalducciL., LymanG.H., ErshlerW.B., eds. Comprehensive Geriatric Oncology.Amsterdam, The Netherlands: Harwood Academic Publ; 1998: 721–732.
36.
WillmanC.L.The prognostic significance of the expression and function of multidrug resistance transporter proteins in acute myeloid leukemia: studies of the Southwest Oncology Group Leukemia Research Program. Semin Hematol.1997; 34(suppl 5): 25–33.
37.
PretiH.A., CabanillasF., TalpazM.Prognostic value of serum interleukin-6 in diffuse large-cell lymphoma. Ann Intern Med.1997; 127: 186–194.
NewcombP.A., CarboneP.P.Cancer treatment and age: patient perspectives. J Natl Cancer Inst.1993; 85: 1580–1584.
41.
ChristmanK., MussH.B., CaseL.D.Chemotherapy of metastatic breast cancer in the elderly: the Piedmont Oncology Association experience. JAMA.1992; 268: 57–62.
42.
IbrahimN., BuzdarA., FryeD.Should age be a determinant factor in treating breast cancer patients with combination chemotherapy?Proc Annu Meet Am Soc Clin Oncol.1993; 12: 68.
43.
Giovanazzi-BannonS., RademakerA., LaiG.Treatment tolerance of elderly cancer patients entered onto phase II clinical trials: an Illinois Cancer Center study. J Clin Oncol.1994; 12: 2447–2452.
44.
GelmanR.S., TaylorSG4th. Cyclophosphamide, methotrexate and 5-fluorouracil chemotherapy in women more than 65 year old with advanced breast cancer: the elimination of age trend in toxicity by using doses based on creatinine clearance. J Clin Oncol.1984; 2: 1404–1413.
45.
BalducciL.Special problems in the management of older persons with cancer. ASCO educational booklet; 1999.
46.
SteinB.N., PetrelliN.J., DouglassH.O.Age and sex are independent predictors of 5-fluorouracil toxicity: analysis of a large scale phase III trial. Cancer.1995; 75: 11–17.
GomezH., MasL., CasanovaL.Elderly patients with aggressive non-Hodgkin's lymphoma treated with CHOP chemotherapy plus granulocyte-macrophage colony-stimulating factor: identification of two age subgroups with differing hematological toxicity. J Clin Oncol.1998; 16: 2352–2358.
49.
ArmitageJ.O., PotterJ.F.Aggressive chemotherapy for diffuse histiocytic lymphoma in the elderly: increased complications with advancing age. J Am Geriatr Soc.1984; 32: 269–273.
50.
BalducciL.Corcoran MB. Antineoplastic chemotherapy of the older cancer patient. Hematol Oncol Clin North Am.2000; 14: 193–212.
51.
GurneyH.Dose calculation of anticancer drugs: a review of current practice and introduction of an alternative. J Clin Oncol.1996; 14: 2590–2611.
52.
BorkowskiJ.M., DuerrM., DonehowerR.C.Relation between age and clearance rate of nine investigational anticancer drugs from phase I pharmacokinetic data. Cancer Chemother Pharmacol.1994; 33: 493–496.
53.
BastionY., BlayJ.Y., DivineM.Elderly patients with aggressive non-Hodgkin's lymphoma: disease presentation, response to treatment, and survival: a Groupe d'Etude des Lymphomes de l'Adulte study on 453 patients older than 69 years. J Clin Oncol.1997; 15: 2945–2953.
54.
SonneveldP., de RidderM., van der LelieH.Comparison of doxorubicin and mitoxantrone in the treatment of elderly patients with advanced diffuse non-Hodgkin's lymphoma using CHOP vs CNOP chemotherapy. J Clin Oncol.1995; 13: 2530–2539.
55.
TirelliU., ErranteD., Van GlabbekeM.CHOP is the standard regimen in patients > or = 70 years of age with intermediate-grade and high-grade non-Hodgkin's lymphoma: results of a randomized study of the European Organization for Research and Treatment of Cancer Lymphoma Cooperative Study Group. J Clin Oncol.1998; 16: 27–34.
56.
SilberJ.H., FridmanM., DiPaolaR.S.First-cycle blood counts and subsequent neutropenia, dose reduction or delay in early-stage breast cancer therapy. J Clin Oncol.1998; 16: 2392–2400.
57.
RatainM.J., SchilskyR.L., ChoiK.E.Adaptive control of etoposide administration: impact of interpatient pharmacodynamic variability. Clin Pharmacol Ther.1989; 45: 226–233.
58.
PierelliL., PerilloA., GreggiS.Erythropoietin addition to granulocyte colony-stimulating factor abrogates life-threatening neutropenia and increases peripheral-blood progenitor-cell mobilization after epirubicin, paclitaxel and cisplatin combination chemotherapy: results of a randomized comparison. J Clin Oncol.1999; 17: 1288–1296.
59.
GabriloveJ.L., EinhornL.H., LivingstonR.B.Once weekly dosing of epoetin alfa is similar to three-times weekly dosing in increasing hemoglobin and quality of life. Proc Annu Meet Am Soc Clin Oncol.1999; 18: A574.
60.
GlaspyJ., BukowskiR., SteinbergD.Impact of therapy with epoetin alfa on clinical outcomes in patients with non-myeloid malignancies during cancer chemotherapy in community oncology practice. Procrit Study Group. J Clin Oncol.1997; 15: 1218–1234.
61.
DemetriG.D., KrisM., WadeJ.Quality-of-life benefit in chemotherapy patients treated with epoetin alfa is independent of disease response or tumor type: results from a prospective community oncology study. J Clin Oncol.1998; 16: 3412–3425.
62.
ReubenD.B., FrankJ.C., HirschS.H.A randomized clinical trial of outpatient geriatric assessment (CGA), coupled with an intervention, to increase adherence to recommendations. J Am Geriatr Soc.1999; 47: 269–276.
63.
TinettiM.E., BakerD.I., McAvayG.A multifactorial intervention to reduce the risk of falling among elderly people living in the community. N Engl J Med.1994; 331: 821–827.