How Clinical Trial Data Sharing Platforms Can Advance the Study of Biomarkers

Abstract

Although data sharing platforms host diverse data types the features of these platforms are well-suited to facilitating biomarker research. Given the current state of biomarker discovery, an innovative paradigm to accelerate biomarker discovery is to utilize platforms such as Vivli to leverage researchers' abilities to integrate certain classes of biomarkers.

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References

Bauchner

et al., “Data Sharing: An Ethical and Scientific Imperative,” JAMA 315, no. 12 (2016): 1238–1240.

Mello

, et al., “Preparing for Responsible Sharing of Clinical Trial Data,” New England Journal of Medicine 369, no. 17 (2013): 1651-1658; see <https://nam.edu/moving-data-shar-ing-forward-the-launch-of-the-vivli-platform/> (last visited July 8, 2019).

Institute of Medicine, Sharing Clinical Trial Data: Maximizing Benefits, Minimizing Risk (Washington, DC: The National Academies Press, 2015), available at <https://doi.org/10.17226/18998> (last visited July 8, 2019).

B. E.

Bierer

, et al., “A Global, Neutral Platform for Sharing Trial Data,” New England Journal of Medicine 374, no. 25 (2016): 2411-2413.

Rockhold ,

Nisen , and

Freeman , “Data Sharing at a Crossroads,” New England Journal of Medicine 375, no. 12 (2016): 1115-1117.

J. S.

Ross

, et al., “Overview and Experience of the YODA Project with Clinical Trial Data Sharing after 5 years,” Scientific Data 5 (2018): article number 180268.

D. A.

Zarin and

Tse , “Sharing Individual Participant Data (IPD) Within the Context of the Trial Reporting System (TRS),” PLoS Medicine 13, no. 1 (2016): e1001946.

T. P. A.

Debray ,

K. G. M.

Moons ,

van Valkenhoef , et al., “Get Real in Individual Participant Data (IPD) Meta-Analysis: A Review of the Methodology,” Research Synthesis Methods 6, no. 4 (2015): 293–309.

S. J.

Nevitt

, et al., “Exploring Changes Over Time and Characteristics Associated with Data Retrieval Across Individual Participant Data Meta-Analyses: A Systematic Review,” BMJ 357 (2017): j1390.

10.

See <https://www.nlm.nih.gov/cde/> (last visited July 8, 2019).

11.

Bakkar ,

Boehringer , and

Bowser , “Use of Biomarkers in ALS Drug Development and Clinical Trials,” Brain Research 1607 (2015): 94–107.

12.

J. G.

Sledge ,

R. S.

Miller , and

Hauser , “CancerLinQ and the Future of Cancer Care,” American Society of Clinical Oncology Educational Book (2013): 430-434.

13.

American Society of Clinical Oncology, Annual Meeting, American Society of Clinical Oncology Educational Book, 430-434;

Green

, et al., “The Project Data Sphere Initiative: Accelerating Cancer Research by Sharing Data,” Oncologist 20, no. 5 (2015): 464-e20, doi: 10.1634/theoncologist.2014-0431.