Objective:To review the English-language literature as it relates to the rat intraovarian insulin-like growth factor (IGF) systgem, special emphasis being placed on the hypotheses under study.
Methods:A thorough literature review of the English-language literature.
Results:Current data support the view that intraovarian IGF-I may act as an amplifier of gonadotropin hormonal action. The role of IGF-I as a determinant of follicular fate remains a matter of study.
Conclusions:The intraovarian IGF-I system may play a central role in ovarian physiology by amplifying gonadotropin hormonal action and, possibly, by playing a role in determining follicular fate.
1. Liu J-P, Baker J, Perkins AS, Robertson EJ, Efstratiadis A. Mice carrying null mutations of the genes encoding insulin-like growth factor 1 (Igf-1) and type 1 IGF receptor (Igf1r). Cell1993;75:59-72.
2.
2. Efstratiadis A. IGFs and dwarf mice: Genetic and epigenetic control of embryonic growth. In: Sizonenko PC, Aubert ML, VAssali J-D, eds. Developmental endocrinology, frontiers in endocrinology. Vol. 6. Ares-Serono Symposia Publications, 1994:27-43.
3.
3. Nakatani A, Shimasaki S, Erickson GF, Ling N. Tissue-specific expression of four insulin-like growth factor-binding proteins (1,2,3, and 4) in the rat ovary. Endocrinology1991;129:1521-1529.
4.
4. Erickson GF, Nakatani A, Ling N, Shimasaki S. Cyclic changes in insulin-like growth factor binding protein-4 messenger ribonucleic acid in the rat ovary. Endocrinology1992;130:625-636.
5.
5. Erickson G, Nakatani A, Ling N, Shimasaki S. Localization of insulin-like growth factor-binding protein-5 messenger ribonucleic acid in rat ovaries during the estrous cycle. Endocrinology1992;130:1867-1878.
6.
6. Oliver JE, Aitman TJ, Powell JF, Wilson CA, Clayton Rn. Insulin-like growth factor I gene expression in the rat ovary is confined to the granulosa cells of developing follicles. Endocrinology1989;124:2671-2679.
7.
7. Zhou J, Chin E, Bondy C. Cellular pattern of insulin-like growth factor-I (IGF-I) and IGF-I receptor gene expression in the developing and mature ovarian follicle. Endocrinology1991;129:3281-3288.
8.
8. Adashi EY, Resnick EC, Svoboda ME, Van Wyk JJ. Follicle-stimulating hormone enhances somatomedin-C binding to cultured rat granulosa cells: Evidence for cAMP-dependence. J Biol Chem1986;261:3923-3926.
9.
9. Adashi EY, Resnick CE, Svoboda ME, Van Wyk JJ. In vivo regulation of granulosa cell somatomedin-C/insulin-like growth factor-I receptors. Endocrinology1988;122:1383-1390.
10.
10. Adashi Ey, Resnick CE, Vera A. Hernandez ER. In vivo regulation of granulosa cell type I insulin-like growth factor receptors: Evidence for an inhibitory role for the putative endogenous ligand(s) of the ovarian GnRH receptor. Endocrinology1991;128:3130-3138.
11.
11. Adashi EY, Resnick CE, Hernandez ER, Hurwitz A, Rosenfeld RG. Follicle-stimulating hormone inhibits the constitutive release of insulin-like growth factor binding proteins by cultured rat ovarian granulosa cells. Endocrinology1990;126:1305-1307.
12.
12. Adashi Ey, Resnick CE, Hurwitz A, Ricciarelli E, Hernandez ER, Rosenfeld RG. Ovarian granulosa cell-derived insulin-like growth factor binding proteins: Modulatory role of follicle-stimulating hormone. Endocrinology1991;128:754-760.
13.
13. Adashi EY, Resnick, CE, Tedeschi C, Rosenfeld RG. A kinase-mediated regulation of granulosa cell-derived insulin-like growth factor binding proteins: Disparate response sensitivities of distinct IGFBP species. Endocrinology1993;132:1463-1468.
14.
14. Liu X-J, Malkowski M, Guo Y, Erickson GF, Shimasaki S, Ling N. Development of specific antibodies to rat insulin-like growth factor-binding proteins (IGFBP-2 to -6): Analysis of IGFBP production by rat granulosa cells. Endocrinology1993;132:1176-1183.
15.
15. Fielder PJ, Pham H, Adashi EY, Rosenfeld RG. Insulin-like growth factors (IGFs) block FSH-induced proteolysis of IGF-binding protein-5 (BP-5) in cultured t granulosa cells. Endocrinology1993;133:415-418.
16.
16. Adashi EY, Resnick CE, Ricciarelh E, et al. Granulosa cell-derived insulin-like growth factor (IGF) binding proteins are inhibitory of IGF-I hormonal action: Evidence derived from the use of a truncated IGF-I analog. J Clin Invest1992;90:1593-1599.
17.
17. Ui M, Shimonaka M, Shimasaki S. Ling N. An insulin-like growth factor-binding protein in ovarian follicular fluid blocks follicle-stimulating hormone-stimulated steroid production by ovarian granulosa cells. Endocrinology1989;125:912-916.
18.
18. Shimasaki S, Shimonaka M, Ui M, Inouye S, Shibata F, Ling N. Structural characterization of a follicle-stimulating hormone action inhibitor in porcine ovarian follicular fluid. J Biol Chem1990;265:2198-2202.
19.
19. Bicsak TS, Shimonaka M, Malkowski M, Ling N. Insulin-like growth factor-binding prtein (IGFBP) inhibition of granulosa cell function: Effect on cyclic adenosine 3′.5′-monophosphate, deoxyribonucleic acid synthesis, and comparison with the effect of an IGF-I antibody. Endocrinology1990;126:2184-2189.
20.
20. Bicsak TS, Long N, DePaolo LV. Ovarian intrabursal administration of insulin-like growth factor-binding protein inhibits follicle rupture in gonadotropin-treated immature female rats. Biol Reprod1991;44:599-603.
21.
21. Chun S-Y. Tilly JL. Furuta I, Tsafriri A, Hsueh AJW. Gonadotropin suppression of apoptosis in cultured preovulatory follicles: Mediatory role of endogenous IGF-I. Endocrinology1994;135:1845-1853.
24. Adashi EY, Resnick CE, Hurwitz A, et al. The intraovarian IGF system. Growth Reg1992;2:10-16.
25.
25. Hansson H-A, Nilsson A, Isgaard J, et al. Immunohistochemical localization of insulin-like growth factor I in the adult rat. Histochemistry1988;89:403-410.
26.
26. Hernandez ER, Roberts CH, LeRoith D, Adashi EY. Rat ovarian insulin-like growth factor I (IGF-I) gene expression is granulosa cell-selective: 5′UT mRNA variant representation and hormonal regulation. Endocrinology1989;125:572-574.
27.
27. Davoren JB, Kasson BG, Li CH, Hsuch AJW. Specific insulin-like growth factor (IGF) I- and II-binding sites on rat granulosa cells: Relation to IGF action. Endocrinology1986;119:2155-2162.
28.
28. Adashi EY, Resnick CE, Hernandez ER, Svoboda ME, Van Wyk JJ. Characterization and regulation of a specific cell membrane receptor for somatomedin-C/insulin-like growth factor-I in cultured rat granulosa cells. Endocrinology1988;122:194-201.
29.
29. Adashi EY, Resnick CE, Rosenfeld RG. Insulin-like growth factor-I (IGF-I) and IGF-II hormonal action in cultured rat granulosa cells: Mediation via type I but not type II IGF receptors. Endocrinology1989;126:216-222.
31. Adashi EY, Resnick CE, Svoboda ME, Van Wyk JJ. A novel role for somatomedin-C in the cytodifferentiation of the ovarian granulosa cell. Endocrinology1984;115:1227-1229.
32.
32. Adashi EY, REsnick CE, Svoboda ME, Van Wyk JJ. Somatomedin-C synergizes with follicle-stimulating hormone in the acquisition of progesterone biosynthetic capacity by cultured rat granulosa cells. Endocrinology1985;116:2135-2142.
33.
33. Davoren JB, Hsuch AJW, Li CH. Somatomedin-C augments FSH-induced differentiation of cultured rat granulosa cells. Am J Physiol1985;Vol:E26-E33.
34.
34. Adashi EY, Resnick CE, Brodie AMH, Svoboda ME, Van Wyk JJ. Somatomedin-C-mediated potentiation of follicle-stimulating hormone-induced aromatase activity of cultured rat granulosa cells. Endocrinology1985;117:2313-2320.
36. Adashi EY, Resnick CE, Svoboda ME, Van Wyk JJ. Somatomedin-C enhances induction of luteinizing hormone receptors by follicle-stimulating hormone in cultured rat granulosa cells. Endocrinology1985;116:2369-2375.
37.
37. Adashi EY, Resnick CE, Svoboda ME, Van Wyk JJ, Hascall VC, Yanagishita M. Independent and synergistic actions of somatomedin-C in the stimulation of proteoglycan biosynthesis by cultured rat granulosa cells. Endocrinology1986;118:456-459.
38.
38. Bicsak TA, Tucker EM, Cappel S, et al. Hormonal regulation of granulosa cell inhibin biosynthesis. Endocrinology1986;119:2711-2719.
39.
39. Zhien ZZ, Carson RS, Herington AC, Lee VK, Burger HG. Follicle-stimulating hormone and somatomedin-C stimulate inhibin production by rat granulosa cells in vitro. Endocrinology1987;120:1633-1638.
40.
40. Adashi EY, Resnick CE, Sbovoda ME, Van Wyk JJ. Somatomedin-C an amplifier of follicle-stimulating hormone action: Enhanced accumulation of adenosine 3′,5′-cyclic monophosphate. Endocrinology1986;118:149-156.
41.
41. Adashi EY, Resnick CE, Svoboda ME, Van Wyk JJ. Synergistic interactions of somatomedin-C with adenosine 3′,5′-cyclic monophosphate-dependent granulosa cell agonists. Biol Reprod1986;34:81-88.
42.
42. Adashi EY, Resnick CE, May JV, Knecht M, Svoboda ME, Van Wyk JJ. Somatomedin C/insulin-like growth factor I as an amplifier of follicle-stimulating hormone action: Studies on mechanism(s) and site(s) of action in cultured rat granulosa cells. Endocrinology1988;122:1583-1592.
43.
43. Adashi EY, Resnick CE, Rosenfeld RG. IGF-I stimulates granulosa cell-derived insulin-like growth factor binding protein-5: Evidence for mediation via type I IGF receptors. Mol Cell Endocrinol1994;99:279-284.
44.
44. Adashi EY, Resnick CE, Hurwitz A, et al. Insulin-like growth factors: The ovarian connection. Hum Reprod1991;6:1213-1219.
45.
45. Hammond JM, Mondschein JS, Samaras SE, Canning SF. The ovarian insulin-like growth factors, a local amplification mechanism for steroidogenesis and hormone action. J Steroid Biochem Mol Biol1991;40:441-446.
47. Hernandez ER, Roberts CT Jr, Hurwitz A, LeRoith D, Adashi EY. Rat ovarian insulin-like growth factor II gene expression is theca-interstitial cell-exclusive: Hormonal regulation and receptor distribution. Endocrinology1990;127:3249-3251.
48.
48. Levy MJ, Hernandez ER, Adashi EY, Stillman RJ, Roberts CT Jr, LeRoith D. Expression of the insulin-like growth factor (IGF)-I and II and IGF-I and II receptor genes during postnatal development of the rat ovary. Endocrinology1992;131:1202-1206.
49.
49. Hernandez ER, Hurwitz A, Botero L, et al. Insulin-like growth factor receptor gene expression in the rat ovary: Divergent regulation of distinct receptor species. Mol Endocrinol1991;5:1799-1805.
50.
50. Adashi EY, Resnick CE, Ricciarelli E, et al. Local tissue modification of follicle stimulating hormone action. In: Genazzani AR, Petraglia F, eds. Hormones in gyencological endocrinology. Carnforth, England: Parthenon Publishing Group, 1992:255-261.
51.
51. Adashi EY, Resnick CE, Rosenfeld RG, et al. Insulin-like growth factor (IGF) binding protein-1 is an antigonadotropin: Evidence that optimal follicle-stimulating hormone action in ovarian granulosa cells is contingent upon amplification by endogenously-derived IGFs. In: LeRoith Dr, Raizada MK, eds. Current directions in insulin-like growth factor research. New York: Plenum, Adv Exp Med Biol1993;343:337-385.
52.
52. Murphy LJ, Bell GI, Friesen HG. Tissue distribution of insulin-like growth factor-I and -II messenger ribonucleic acid in the adult rat. Endocrinology1987;120:1279-1282.
53.
53. Davoren BJ, Hsuch AJW. Growth hormone increases ovarian levels of immunoreactive somatomedin-C/insulin-like growth factor-I in vivo. Endocrinology1986;118:888-890.
54.
54. Carlsson B, Carlsson L, Billig H. Estrus cycle-dependent co-variation of insulin-like growth factor (IGF-I) messenger-ribonucleic acid and protein in the rat ovary. Mol Cell Endocrinol1989;64:271-275.
55.
55. Botero LF, Kokia E, Ricciarelli E, et al. IGF-I gene expression by primary cultures of ovarian cells: Insulin and dexamethasone-dependence. Endocrinology1993;132:2703-2708.
56.
56. Ricciarelli E, Hernandez ER, Hurwitz A, et al. The ovarian expression of the antigonadotropic insulin-like growth factor binding protein-2 is theca-interstitial cell-selective: Evidence for hormonal regulation. Endocrinology1991;129:2266-2268.
57.
57. Ricciarelli E, Hernandez ER, Kokia E, et al. Rat ovarian insulin-like growth factor binding protein-3: A growth hormone-dependent theca-interstitial cell-derived antigonadotropin. Endocrinology1992;130:3092-3094.
58.
58. Rohan RM, Ricciarelli E, Kiefer MC, Resnick CE, Adashi EY. Rat ovarian insulin-like growth factor binding protein-6: A pituitary-dependent theca-interstitial selective species with limiited antigonadotropic activity. Endocrinology1993;132:2507-2512.
59.
59. Hurwitz A, Adashi EY. Ovarian follicular atresia as an apoptotic process: A paradigm for programmed cell death in endocrine tissues. Mol Cell Endocrinol1992;84:C19-C23.
