Objective:To determine the effect os stage III and IV endometriosis on serum concentration of soluble intracellular adhesion molecule-1 (ICAM-1), vascular cellular adhesion molecule-1 (VCAM-1), and E-selectin.
Methods:Sera from women with laparoscopically proven stage III and IV endometriosis were analyzed for the presence of soluble ICAM-1, VCAM-1, and E-selectin using enzyne-linked immunosorbent assays. Concentrations of these molecules were compared with those of laparoscopically proven disease-free controls.
Results:When compared with controls, women with stage III and IV endometriosis had higher serum concentration of soluble E-selectin.
Conclusion:Significant aberrations in levels of circulating adhesion molecules were found in women with stage III and IV endometriosis. These findings might shed light on the pathogenesis of endometriosis and be useful in the development of biochemical markers for disease stage.
1. Sampson JA. Peritoneal endometriosis due to menstrual dissemination of endometrial tissue into the perioneal cavity. Am J Obstet Gynecol1927'14;422-429.
2.
2. McLaren, J, Prentice A, Charnock-Jones DS, Smith SK. Vascular endothelial growth factor (VEGF) concentrations are elevated in peritoneal fluid of women with endometriosis. Human Reprod1996;11:220-223.
4. Martin DC, Ling FW. Endometriosis and pain. Clinical Obstet Gynecol1999;42:664-686.
5.
5. Strathy JH, Molgaard CA, Coulman CB. Endometriosis and infertility: A laparoscopic study of endometriosis among fertile and infertile women. Fertil Steril1982;38:667-672.
6.
6. Lebovic DI, Mueller MD, Taylor RN. Immunobiology of endometriosis. Fertil Steril2001;75:1-10.
7.
7. Oosterlynck DJ, Cornillie FJ, Waer M, Vandeputte M, Koninckx PR. Women with endometriosis show a defect in natural killer activity resulting in a decreased cytotoxicity to autologous endometrium. Fertil Steril1991;56:45-51.
8.
8. Oosterlynck DJ, Meuleman C, Waer M, Koninckx PR, Vandeputte M. Immunosuppressive activity of peritoneal fluid in women with endometriosis. Obstet Gynecol1993;82:206-212.
9.
9. Hirata J, Kikuchi Y, Imaizumi F, Tode T, Nagata I. Endometriotic tissues produce immunosuppressive factors. Gynecol Obstet Invest1994;37:43-47.
10.
10. Gearing AJH, Newman W. Circulating adhesion molecules in disease. Immunol Today1993;14:506-512.
11.
11. Collins T. Adhesion molecules in leukocyte emigration. Sci Am1995;Nov/Dec:28-35.
13. Djurovic S, Schjetlein R, Wisloff F, Haugen G, Berg K. Increased levels of intercellular adhesion molecules and vascular cell adhesion molecules in pre-eclampsia. Br J Obstet Gynecol1997;104:466-470.
14.
14. Jones SC, Bankd RE, Haidar A, et al. Adhesion molecules in inflammatory bowel disease. Gut1995;36:724-730.
15.
15. Busacca M, Vigano P, Magri B, Vignali M. The adhesion molecules on human endometrial stromal cells. Ann N Y Acad Sci1994;734:43-46.
16.
16. Cannistra SA, Ottensmeier C, Tidy J, DeFranzo B. Vascular cell adhesion molecule-1 expressed by pertoneal mesothelium partly mediates the binding of activated human T lymphocytes. Exp Hematol1994;22:996-1002.
17.
17. Somigliana E, Vigano P, Gaffuri B, Guarneri D, Busacca M, Vignali M. Human endometrial stromal cells as a source of soluble intercellular adhesion molecule (ICAM)-1 molecules. Hum Reprod1996;11:1190-1194.
18.
18. Wu MH, Vang BC, Hsu CC, Lee YC, Huang KE. The expression of soluble intercellular adhesion molecule-1 in endometriosis. Fertil Steril1998;70:1139-1142.
19.
19. De Placido G, Alviggi C, Di Palma G, et al. Serum concentrations of soluble human leukocyte class I antigens and of the soluble intercellular adhesion molecule-1 in endometriosis: Relationship with stage and non-pigmented peritoneal lesions. Hum Reprod1998;13:3206-3210.
20.
20. Revised American Fertility Society classification of endometriosis: 1985. Fertil Steril1985;43:351-352.
21.
21. Eisermann J, Gast MJ, Pineda J, Odem RR, Collins JL. Tumor necrosis factor in peritoneal fluid of women undergoing laparoscopic surgery. Fertil Steril1988;50:573-579.
