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Abstract

The enigma in understanding the regulation of ovarian function throughout the menstrual cycle is that both follicle-stimulating hormone (FSH) and luteinizing homone (LH) act on the ovary, at least in part through the cyclic adenosine monophosphate (cAMP) intracellular signaling pathway. If cAMP is a common intracellular messenger of gonadotropic stimulation during both the follicular and the luteal phases, how can the responses of the follicle and the corpus luteum to their respective trophic homones differ so dramatically? The actions of FSH and LH on the ovary are summarized and a mechanistic hypothesis is provided as to how ovarian cyclicity (initiation of follicular development, selection of a single prevulatory follicle, corpus luteum function, corpus luteum regression, and corpus luteum rescue during early pregnancy) could be controlled by a single intracellular messenger: cAMP.

Keywords

Selection of the preovulatory follicle cAMP gonadotropins corpus luteum function and regression

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References

Zeleznik AJ

Kubik CJ

. Ovarian responses in macaques to pulsatile infusion of FSH and LH: Increased sensitivity of the maturing follicle to FSH. Endocrinology1986;119:2025-2031.

Fauser B

Heusden AV

. Manipulation of human ovarian function: Physiological concepts and clinical consequences. Endocr Rev1997;18:71-106.

Sullivan MW

Stewart-Aikers A

Krasnow JS

Berga SL

Zeleznik AJ

. Ovarian responses in women to recombinant follicle stimulating hormone and luteinizing hormone: A role for LH in the final stages of follicular maturation. J Clin Endocrinol Metab1999;84:228-232.

Hutchison JH

Zeleznik AJ

. The rhesus monkey corpus luteum is dependent upon gonadotropin secretion throughout the luteal phase of the menstrual cycle. Endocrinology1984;115:1780-1786.

Hutchison JS

Zeleznik AJ

. Effect of different gonadotropin pulse frequencies on corpus luteum function in rhesus monkeys. Endocrinology1986;119:1964-1971.

Zeleznik AJ

. In vivo responses of the primate corpus luteum to luteinizing hormone and chorionic gonadotropin. Proc Natl Acad Sci U S A1998;95:1100-1107.

Somers JP

Benyo DF

Little-Ihrig L

Zeleznik AJ

. Luteinization in primates is accompanied by a loss of a 43-kilodalton adenosine 3′,5′-monophosphate response element-binding protein. Endocrinology1995;136:4764-4768.

Huang D

Shippmen-Appsasmy PM

Ortenm DJ

Hinrichsm SH

Prystowsky MB

. Promoter activity of the proliferating-cell nuclear antigen gene is associated with inducible CRE-binding proteins in interleukin 2-stimulated T lymphocytes. Mol Cell Biol1994;4:4233-4243.

Lee BH

Matthews MB

. Transcriptional coactivator cAMP response element binding protein mediates induction of the human proliferating cell nuclear antigen promoter by the adenovirus E1A oncoprotein. Proc Natl Acad Sci U S A1997;94:4481-4486.

10.

Riccio A

Ahn S

Davenport CM

Blendy JA

Ginty DD

. Mediation by a CREB family transcription factor of NGF-dependent survival of sympathetic neurons. Science1999;286:2358-2361.

11.

Wang JM

Chao JR

Chen W

Kuo ML

Yen JJ

Yang-Yen HF

. The antiapoptotic gene mcl-1 is up-regulated by the phosphatidylinositol 3-kinase/Akt signaling pathway through a transcription factor complex containing CREB. Mol Cell Biol1999;19:6195-6206.

Modifications in Gonadotropin Signaling: A Key to Understanding Cyclic Ovarian Function

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