Restricted accessResearch articleFirst published online 2025-9
Getting Under Your Skin (and into your Brain): The Problematic Effects of Galactic Cosmic Radiation on Collaboration and Cognition for Long Distance Space Missions
Galactic Cosmic Radiation (GCR) poses significant risks to astronauts during long-distance space missions. Although much progress is being made in other areas of science and engineering for the future of spaceflight, our understanding of the implications of GCR remains limited. The potential for negative consequences arises, not only with physical health, but also with behavioral and cognitive health. In this paper we briefly review the research linking GCR exposure to problems in cognition. We then provide notional research questions to better assess this impact as it relates to team cognition. Our goal is to highlight the importance of this topic and help develop research questions for understanding the cognitive and collaboration challenges posed by GCR in long distance missions.
AcharyaM. M.BaulchJ. E.KleinP. M.BaddourA. A. D.ApodacaL. A.KramárE. A.AlikhaniL.GarciaC.AnguloM. C.BatraR. S.FallgrenC. M.BorakT. B.LimoliC. L. (2019). New concerns for neurocognitive function during deep space exposures to chronic, low dose-rate, neutron radiation. eNeuro, 6(4), ENEURO.0094-19.2019. https://doi.org/10.1523/ENEURO.0094-19.2019
2.
AlaghbandY.BoubacarD.AkbarM.StanforthR.LeeJ.ChmielewskiN. N.LimoliC. L. (2023). Galactic cosmic radiation exposure causes multifaceted neurocognitive impairments. Cellular and Molecular Life Sciences, 80(1), 29. https://doi.org/10.1007/s00018-022-04666-8
3.
BabuB.PawarS.MittalA.KolanthaiE.NealC. J.CoathupM.SealS. (2023). Nanotechnology enabled radioprotectants to reduce space radiation-induced reactive oxidative species. Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 15(5), e1896. https://doi.org/10.1002/wnan.1896
4.
BiermannP. L.KronbergP. P.AllenM. L.MeliA.SeoE.-S. (2019). The origin of the most energetic galactic cosmic rays: Supernova explosions into massive star plasma winds. Galaxies, 7(2), 48. https://doi.org/10.3390/galaxies7020048
5.
ChenZ.LiY.RasheedM.WangH.LeiR.ZhaoT.DengY.MaH. (2023). Altered expression of inflammation-associated molecules in striatum: An implication for sensitivity to heavy ion radiations. Frontiers in Cellular Neuroscience, 17, 1252958. https://doi.org/10.3389/fncel.2023.1252958
6.
DeChurchL. A.LungeanuA.ContractorN. S. (2024). Think like a team: Shared mental models predict creativity and problem-solving in space analogs. Acta Astronautica, 214, 701–711. https://doi.org/10.1016/j.actaastro.2023.10.022
7.
DesaiR. I.KangasB. D.LucO. T.SolakidouE.SmithE. C.DawesM. H.MaX.MakriyannisA.ChatterjeeS.DayehM. A.Muñoz-JaramilloA.DesaiM. I.LimoliC. L. (2023). Complex 33-beam simulated galactic cosmic radiation exposure impacts cognitive function and prefrontal cortex neurotransmitter networks in male mice. Nature Communications, 14(1), 7779. https://doi.org/10.1038/s41467-023-42173-x
8.
DesaiR. I.LimoliC. L.StarkC. E. L.StarkS. M. (2022). Impact of spaceflight stressors on behavior and cognition: A molecular, neurochemical, and neurobiological perspective. Neuroscience and Biobehavioral Reviews, 138, 104676. https://doi.org/10.1016/j.neubiorev.2022.104676
9.
DuttaS. M.HadleyM. M.PetermanS.JewellJ. S.DuncanV. D.BrittenR. A. (2018). Quantitative proteomic analysis of the hippocampus of rats with GCR-induced spatial memory impairment. Radiation Research, 189(2), 136–145. https://doi.org/10.1667/RR14822.1
10.
FaisG.MancaA.BolognesiF.BorselliM.ConcasA.BusuttiM.BroggiG.SannaP.Castillo-AlemanY. M.Rivero-JiménezR. A.Bencomo-HernandezA. A.Ventura-CarmenateY.AlteaM.PantaleoA.GabrielliG.BiglioliF.CaoG.GiannaccareG. (2022). Wide range applications of Spirulina: From Earth to space missions. Marine Drugs, 20(5), 299. https://doi.org/10.3390/md20050299
11.
FioreS. M.KäosaarA.WiltshireT. J. (2024). An operational assessment of team cognition for long-distance space missions. Proceedings of the Human Factors and Ergonomics Society Annual Meeting, 68(1), 1316–1322. https://doi.org/10.1177/10711813241284572
12.
FioreS. M.WiltshireT. J.SanzE. J. (2015). Critical team cognitive processes for long-duration exploration missions (NASA TM-2015-218583). NASA Technical Memorandum. https://ntrs.nasa.gov/citations/20150019648
13.
FischerU.MosierK.OrasanuJ. (2013). The impact of transmission delays on mission control–space crew communication. Proceedings of the Human Factors and Ergonomics Society Annual Meeting, 57(1), 1372–1376. https://doi.org/10.1177/1541931213571303
14.
GoldenS. J.ChangC.-H. (Daisy)KozlowskiS. W. J. (2018). Teams in isolated, confined, and extreme (ICE) environments: Review and integration. Journal of Organizational Behavior, 39(6), 701–715. https://doi.org/10.1002/job.2288
15.
JandialR.HoshideR.WatersJ. D.LimoliC. L. (2018). Space–brain: The negative effects of space exposure on the central nervous system. Surgical Neurology International, 9, 9. https://doi.org/10.4103/sni.sni_250_17
16.
KäosaarA.FioreS. M.GomezC.BurkeC. S. (2024). Understanding team cognition in support of long-distance space missions. Proceedings of the Human Factors and Ergonomics Society Annual Meeting, 68(1), 1837–1842. https://doi.org/10.1177/10711813241260664
17.
KäosaarA.Marques-QuinteiroP.BurkeS. (2021). Fantastic teams and where to find them: Understanding team processes in space and analog environments through the IMOI framework. Team Performance Management, 28(3–4), 109–124. https://doi.org/10.1108/TPM-02-2021-0012
18.
KifferF.BoermaM.AllenA. (2019). Behavioral effects of space radiation: A comprehensive review of animal studies. Life Sciences in Space Research, 21, 1–21. https://doi.org/10.1016/j.lssr.2019.02.004
19.
KleinP. M.GhoshS.GoswamiM.Romero-WeaverA. L.BrittenR. A. (2021). Detrimental impacts of mixed-ion radiation on nervous system function. Neurobiology of Disease, 151, 105252. https://doi.org/10.1016/j.nbd.2021.105252
KrukowskiK.FengX.PaladiniM. S.SacramentoK.GrueK.RiparipL.-K.JonesT.Campbell-BeachlerM.NelsonG. A.RosiS. (2021). The impact of deep space radiation on cognitive performance: From biological sex to biomarkers to countermeasures. Science Advances, 7(42), eabg6702. https://doi.org/10.1126/sciadv.abg6702
22.
LiuQ.HuangY.DuanM.YangQ.RenB.TangF. (2022). Microglia as therapeutic target for radiation-induced brain injury. International Journal of Molecular Sciences, 23(15), 8286. https://doi.org/10.3390/ijms23158286
LuebkeM.ParulekarM.ThomasF. P. (2023). Fluid biomarkers for the diagnosis of neurodegenerative diseases. Biomedicine & Pharmacotherapy, 8, 100062. https://doi.org/10.1016/j.bionps.2023.100062
25.
LungeanuA.Mesmer-MagnusJ. R.NilerA. A.DeChurchL. A.ContractorN. S. (2023). Organizing for Mars: A task management perspective on work within spaceflight multiteam systems. Human Factors, 65(6), 1199–1220. https://doi.org/10.1177/00187208221129939
26.
MarcinkowskiM. A.BellS. T.RomaP. G. (2021). The nature of conflict for teams in isolated, confined, and extreme environments. Acta Astronautica, 181, 81–91. https://doi.org/10.1016/j.actaastro.2021.01.004
Montay-GruelP.AcharyaM. M.PeterssonK.AlikhaniL.YakkalaC.AllenB. D.BaddourA. A. D.GonzalezA.BatraR.TaghaviS.LimoliC. L. (2019). Long-term neurocognitive benefits of FLASH radiotherapy driven by reduced reactive oxygen species. Proceedings of the National Academy of Sciences of the United States of America, 116(22), 10943–10951. https://doi.org/10.1073/pnas.1901777116
29.
PalinkasL. A.SuedfeldP. (2021). Psychosocial issues in isolated and confined extreme environments. Neuroscience and Biobehavioral Reviews, 126, 413–429. https://doi.org/10.1016/j.neubiorev.2021.03.032
PariharV. K.AllenB. D.CaressiC.KwokS.ChuE.TranK. K.ChmielewskiN. N.CraverB. M.BaulchJ. E.AcharyaM. M.LimoliC. L. (2020). Sex-specific cognitive deficits following space radiation exposure. Frontiers in Behavioral Neuroscience, 14, 535885. https://doi.org/10.3389/fnbeh.2020.535885
32.
PariharV. K.MarosoM.SyageA.AllenB. D.AnguloM. C.SolteszI.LimoliC. L. (2018). Persistent nature of alterations in cognition and neuronal circuit excitability after exposure to simulated cosmic radiation in mice. Experimental Neurology, 305, 44–55. https://doi.org/10.1016/j.expneurol.2018.03.009
33.
ParisiM. E.McTigueK. R.PanontinT. L.WuS.-C.VeraA. H. (2022, May). Extreme problem solving II: How can 4 astronauts do the jobs of 80 experts? In SpaceCHI 2.0: Advancing Human-Computer Interaction for Space Exploration, New Orleans, LA. NASA. https://ntrs.nasa.gov/citations/20220005539
34.
PatelZ. S.BrunstetterT. J.TarverW. J.WhitmireA. M.ZwartS. R.SmithS. M.HuffJ. L. (2020). Red risks for a journey to the red planet: The highest priority human health risks for a mission to Mars. NPJ Microgravity, 6, 33. https://doi.org/10.1038/s41526-020-00124-6
35.
RaberJ.AllenA. R.SharmaS.AllenB.RosiS.OlsenR. H. J.DavisM. J.EiwazM.FikeJ. R.NelsonG. A.VlkolinskýR. (2019). Combined effects of three high-energy charged particle beams important for space flight on brain, behavioral, and cognitive endpoints in B6D2F1 female and male mice. Frontiers in Physiology, 10, 179. https://doi.org/10.3389/fphys.2019.00179
36.
RieneckerK. D. A.PaladiniM. S.GrueK.KrukowskiK.RosiS. (2021). Microglia: Ally and enemy in deep space. Neuroscience and Biobehavioral Reviews, 126, 509–514. https://doi.org/10.1016/j.neubiorev.2021.03.036
SimonsenL. C.SlabaT. C.GuidaP.RusekA. (2020). NASA’s first ground-based Galactic Cosmic Ray Simulator: Enabling a new era in space radiobiology research. PLOS Biology, 18(5), e3000669. https://doi.org/10.1371/journal.pbio.3000669
39.
TosunD.LandauS.AisenP. S.PetersenR. C.JackC. R.JagustW.WeinerM. W. (2021). Detection of β-amyloid positivity in Alzheimer’s Disease Neuroimaging Initiative participants with demographics, cognition, MRI, and plasma biomarkers. Brain Communications, 3(2), fcab008. https://doi.org/10.1093/braincomms/fcab008
