Tissue Concentrations after a Single-Dose,Orally Administered Ofloxacin in Patients with Diabetic Foot Infections

Abstract

We studied the penetration of orally administered ofloxacin at the site of diabetes-related foot infections in patients with a planned debridement of the lesion. A total of nine patients received 800 mg of oral ofloxacin 120 to 150 minutes before surgery. During surgery, vital margin tissue and a serum sample were obtained. Serum and tissue concentrations of ofloxacin were measured. From seven patients sufficient amounts of tissue were obtained. Mean serum concentration was 7.0 ± 3.5 mg/liter; mean tissue concentrations was 11.5 ± 8.4 mg/kg. Mean serum and tissue concentrations exceed the minimal inhibitory concentration₉₀ (MIC₉₀) of commonly involved pathogens. This indicates that orally administered ofloxacin can be an effective treatment for infected diabetic foot lesions.

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References

1. Anonymous: NCCLS Interpretive Tables. ANNLDO, 7: 25–30, 1990.

2. Duckworth

Fisher

J. F.

Carter

S. A.

et al.: Tissue penetration of clindamycin in diabetic foot infections. J. Antimicrob. Chemother., 31: 581–584, 1993.

3. Fuchs

P. C.

: In vitro antimicrobial activity and susceptibility testing of ofloxacin: current status. Am. J. Med., 87(6C): S10–S13, 1989.

4. Gentry

L. O.

: Diagnosis and management of the diabetic foot ulcer. J. Antimicrob. Chemother., 32(suppl A): 77–89, 1993.

5. Gerding

D. N.

Hitt

J. A.

: Tissue penetration of the new quinolones in humans. Rev. Infect. Dis., 11(suppl 5): S1046–S1057, 1989.

6. Kong

M. F.

Macdonald

I. A.

Tattersall

R. B.

: Gastric emptying in diabetes. Diabet. Med., 13: 112–119, 1996.

7. Perea

E. J.

: Ofloxacin concentrations in tissues involved in respiratory tract infections. J. Antimicrob. Chemother., 26(suppl D): 55–60, 1990.

8. Pijnenburg

C. C.

Teulings

C. J. A.

Philipse

R. C. A.

et al.: Het scheiden van geneesmiddelen op ge-endcapte octadecylsilyl HPLC-kolommen: niet alleen natte-vinger werk. [Separation of pharmaceuticals on endcapped octadecylsilyl HPLC columns: more than trial and error]. Ziekenhuisfarmacie, 9: 24–29, 1993.

9. Sato

Inoue

Fujii

Aoyama

Mitsuhashi

: Antibacterial activity of ofloxacin and its mode of action. Infection, 14(suppl 4): 226–230, 1986.

10.

10. Seabrook

G. R.

Edmiston

C. E.

Schmit

D. D.

et al.: Comparison of serum and tissue antibiotic levels in diabetes related foot infections. Surgery, 110: 671–676, 1991.

11.

11. Storm

A. J.

Bouter

K. P.

Diepersloot

R. J. A.

et al.: Tissue concentrations of an orally administered antibiotic in diabetic patients with foot infections. J. Antimicrob. Chemother., 34: 449–451, 1994.

12.

12. Warlich

Korting

H. C.

Schafer Korting

Mutschler

: Multiple-dose pharmacokinetics of ofloxacin in serum, saliva, and skin blister fluid of healthy volunteers. Antimicrob. Agents Chemother., 34: 78–81, 1990.

13.

13. West

N. J.

: Systemic antimicrobial treatment of foot infections in diabetic patients. Am. J. Health Syst. Pharm., 52: 1199–1207, 1995.

14.

14. Wolfson

J. S.

Hooper

D. C.

: Comparative pharmacokinetics of ofloxacin and ciprofloxacin. Am J Med., 87(6C): S31–S36, 1989.