Achilles tendon pain or rupture after fluoroquionolone treatment has been described as an uncommon adverse effect. We report two patients with ciprofloxacin-associated Achilles tendon disease, one with histopathological examination. Microscopic evaluation showed irregular collagen fiber arrangement, hypercellularity, and increased interfibrillar glycosaminoglycans. These pathological features are also seen in tendon overuse injuries in athletes.
Get full access to this article
View all access options for this article.
References
1.
. JorgensenC.AnayaJ.M.DidryC.CanovasF.SerreI.BaldetP.KahnM.F.SanyJ.: Arthropathies et tendinopathie achilléenne intuites par la péfloxacine; a propos d'une observation. Rev. Rhum. Mal. Ostéoartic., 58:623–625, 1991.
2.
. KatoM.TakadaS.KashidaY.NomuraM.: Histological examination on Achilles tendon lesions induced by quinolone antibacterial agents in juvenile rats. Toxicol. Pathol., 23:385–392, 1995.
3.
. MartensM.WoutersP.BurssensA.MulierJ.C.: Patellar tendinitis: pathology and results of treatment. Acta Orthop. Scand., 53:445–450, 1982.
4.
. MovinT.GadA.ReinholtF.P.RolfC.: Tendon histopathology in longstanding achillodynia: biopsy findings in 40 patients. Acta Orthop. Scand., 68:170–175, 1997.
5.
. RoyerR.J.PierfitteC.NetterP.: Features of tendon disorders with fluoroquinolones. Therapie, 49:75–76, 1994.
