Intra-articular radiation treatment using dysprosium-165 ferric hydroxide macroaggregate has been performed on eight patients with refractory synovitis of the ankle. Seventy-five percent (six patients) responded well to the treatment, and there were no complications from the injection. Although ankle synovectomy is not often indicated, those patients with rheumatoid synovitis without significant joint destruction respond favorably to radiation treatment.
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References
1.
. ElboarJ.E.ThomasW.H.WeinfeldM.S.PotterT.A.: Talonavicular arthrodesis for rheumatoid arthritis of the hindfoot. Orthop. Clin. North Am., 7:821, 1976.
2.
. FerkelR.D.: Soft tissue pathology of the ankle. In Operative Arthroscopy. McGintyJ.B. (eds.), New York, New York, Raven Press, p. 713, 1991.
3.
. GschwendN.: Synovectomy. In Textbook of Rheumatology, 3rd Ed. KelleyW.N.HarrisE.D.RuddyS.SledgeC.B. (eds.), Philadelphia, W. B. Saunders, pp. 1934–1961, 1989.
4.
. GumpelJ.M.BeerT.C.CrawleyJ.C.FarranH.E.: 90Yttrium in persistent synovitis of the knee: a single center of comparison of four radiocolloids. Br. J. Radiol., 48:377, 1975.
5.
. HeywoodA.W.B.: Rheumatoid arthritis—the orthopaedic contribution III. The trunk and lower limb. S. Afr. Med. J., 41:267, 1967.
6.
. HnatowichD.J.KramerR.I.SledgeC.B.NobleJ.ShortkroffS.: Dysprosium-165 ferric hydroxide macroaggregates* for radiation synovectomy. J. Nucl. Med., 19:303, 1978.
7.
. JakubowskiS.: Synovectomy in rheumatoid arthritis. In Synovectomy and Arthroplasty in Rheumatoid Arthritis. ChapchalG. (ed.), New York, Intercontinental Medical Book Corp., p.* 1967.
8.
. JakubowskiS.: Synowektomia stawv skokowogeleniowego gos' ccu przewleklym postepujacym (Ankle joint synovectomy in rheumatoid arthritis). Chir. Narzadow Ruchu Ortop. Pol., 35:683, 1970.
9.
. KirkupJ.: Rheumatoid arthritis and ankle surgery. Ann. Rheum. Dis., 49(Suppl 2):837–844, 1990.
10.
. MohingW.KohlerG.ColdewayJ.: Synovectomy of the ankle joint. Int. Orthop., 6:117–121, 1982.
11.
. NobleJ.JonesA.G.DavisM.A.SledgeC.B.KramerR.I.LiviniE.: Leakage of radioactive particle systems from a synovial joint studied with a gamma camera: its application to radiation synovectomy. J. Bone Joint Surg., 65A:381, 1983.
12.
. ParisienJ.S.ShereffM.J.: The role of arthroscopy in the diagnosis and management of disorders of the ankle. Foot Ankle, 2:144–149, 1981.
13.
. PetersonL.F.A.: Surgery for rheumatoid arthritis—timing and techniques: the lower extremity. J. Bone Joint Surg., 50A:587, 1968.
. SledgeC.B.ZuckermanJ.D.ShortkroffS.ZalutskyM.R.VenkatesanP.SnyderM.A.BarrettW.P.: Synovectomy of the rheumatoid knee using intra-articular injection of dysprosium-1 65 ferric hydroxide macroaggregates. J. Bone Joint Surg., 69A:970, 1987.
16.
. SledgeC.B.ZuckermanJ.D.ZalutskyM.R.AtcherR.W.ShortkroffS.LionbergerD.R.RoseH.A.HursonB. JLankennerP.A.Jr.AndersonR.J.BloomerW.A.: Treatment of rheumatoid synovitis of the knee with intra-articular injection of dysprosium-165 ferric hydroxide macroaggregates. Arthritis Rheum., 29:153, 1986.
17.
. SteinbrockerO.TraegerC.H.BattermanR.C.: Therapeutic criteria in rheumatoid arthritis. J. A. M. A., 140:659, 1949.
18.
. VahvanenV.: Synovectomy of the talocrural joint in rheumatoid arthritis. Ann. Chir. Gynaecol. Fenn., 57:576, 1968.
19.
. VainioK.: Orthopaedic surgery in the treatment of rheumatoid arthritis. Ann. Clin. Res., 7:216, 1975.
20.
. VainioK.: The ankle joint. Ann. Chir. Gynaecol., 45(Suppl 1):9, 1956.
21.
. VidigalE.JacobyR.K.DixonA.St. RatliffJ.A.H.KirkupJ.: The foot in chronic rheumatoid arthritis. Ann. Rheum. Dis., 34:292, 1975.
. ZalutskyM.R.VenkatesanP.P.EnglishR.J.ShortkroffS.SledgeC.B.AdelsteinS.J.: Radiation synovectomy with 165 Dy-FHMA: lymph node uptake and radiation dosimetry calculations. Int. J. Nucl. Med. Biol., 12:457, 1986.
24.
. ZuckermanJ.D.SledgeC. BShortkroffS.VenkatesanP.: Treatment of antigen-induced arthritis in rabbits with dysprosium-165 ferric hydroxide macroaggregates. J. Orthop. Res., 7:50, 1989.