Abstract
Background:
Bone marrow stimulation (BMS) is the most frequently performed surgical procedure for osteochondral lesions of the talus (OLTs). After the surgical intervention, one of the first goals of rehabilitation is to resume weightbearing. This study aims to compare clinical and radiologic outcomes between immediate weightbearing and delayed weightbearing, which represent unrestricted weightbearing and weightbearing starting at 6 weeks postoperatively.
Methods:
All patients who underwent BMS for their OLT between July 2019 and September 2022 in our clinic were screened for eligibility. Patients were retrospectively included with prospective collected data and were matched into 2 groups, the immediate weightbearing group or the delayed weightbearing group. The following variables were used for matching: age, gender, side, lesion size (volume and surface measured on CT scans), primary or nonprimary lesion, body mass index (BMI) and the numeric rating scale (NRS) of pain during walking. The primary outcome of this study is the comparison of the change in NRS of pain during walking between baseline and 12 months postoperatively, between both groups. Secondary outcomes consist of change in the NRS of pain during running, NRS pain during stairclimbing, NRS pain during rest, 36-Item Short Form Health Survey, Foot and Ankle Outcome Score, return to work, return to sport, and radiologic outcomes between both groups at 12 months.
Results:
After matching, 13 patients per group were included. Both groups showed improvement in NRS pain during walking from baseline to 12 months postoperatively. The difference in change scores between immediate and delayed weightbearing was not statistically significant (
Conclusion:
This matched cohort study found no statistically significant difference in clinical or radiologic outcomes at 12 months between immediate and delayed weightbearing following arthroscopic BMS for talar osteochondral lesions. Although early weightbearing may be feasible and well tolerated, the small sample size and wide CIs limit the strength of conclusions. These findings should be considered hypothesis-generating and underscore the need for larger, prospective trials.
Introduction
Bone marrow stimulation (BMS) is the most frequently performed surgical procedure for osteochondral lesions of the talus (OLTs). 4 This procedure aims to alleviate symptoms by facilitating sufficient bony filling and the formation of fibrocartilage following debridement of an OLT. After surgical intervention, rehabilitation is required to regain ankle function. 1 One of the first steps in rehabilitation is resumption of weightbearing. As it is known that loading plays a role in the quality and volume of osteochondral lesion repair tissue, postoperative weightbearing after BMS is an important topic. 2 Historical assumptions that a certain period of nonweightbearing (NWB) is required to facilitate cartilage restoration after BMS has led to a more conservative management in the postoperative treatment strategies after BMS. 13
In the current literature, resumption of weightbearing is divided into 2 different strategies: early weightbearing and delayed weightbearing. Different definitions exist for early weightbearing and delayed weightbearing. 20 Early weightbearing is considered as resumption of (partial) weightbearing between day 1 and week 2 postoperative, whereas delayed weightbearing is considered as resuming (partial) weightbearing from week 6 or later. 20 In the current literature, most articles support the benefits of resumption of partial weightbearing within the first week and resuming full weightbearing at 6 weeks.6,8,11
Both early weightbearing and delayed weightbearing yield satisfactory clinical outcomes (ie, pain and function) and no differences between these 2 strategies were observed in prior studies.5,11 The clinical advantage of early weightbearing relies on the fact that patients are less restricted in their activities, which possibly leads to higher satisfaction rates and improved (early) clinical outcomes. Another advantage of early weightbearing is that movement restrictions can be avoided as patients with weightbearing constraints often demonstrate noncompliance in relation to weightbearing restrictions.3,15 Additionally, it can lead to earlier return to sport and return to work compared with delayed weightbearing. However, the literature on early weightbearing is scarce. To our knowledge, no prospective registered comparative studies comparing early weightbearing, considered as immediate unrestricted weightbearing, with delayed weightbearing (6 weeks nonweightbearing) without bracing or splinting have been published. Additionally, outcomes on return to work and return to sport are limited. The aim of this study is to add knowledge on clinical outcomes and safety of immediate weightbearing after arthroscopic BMS.
Methods
This study is a retrospective analysis of prospectively collected data. The study was approved by the Medical Ethics Committee at the University of Amsterdam (reference number: 08/326) and is written in accordance with the Declaration of Helsinki. Informed consent was obtained from all patients included in the study.
Patient Selection
All patients who underwent arthroscopic BMS for OLTs in our clinic between July 2019 and September 2022 were screened for eligibility. The inclusion and exclusion criteria are presented in Table 1. After applying the inclusion and exclusion criteria, patients were matched into 2 groups, the immediate weightbearing group or the delayed weightbearing group, based on received postoperative weightbearing protocol. Both protocols are described in Table 2. The choice of postoperative protocol was solely based on the treating surgeons’ preference, without any other influencing factors. This nonrandom allocation may have introduced selection bias and limits the ability to infer causality.
Exclusion and Inclusion Criteria.
Abbreviations: ATFL, anterior talofibular ligament; BMS, bone marrow stimulation; CRPS, complex regional pain syndrome; CT, Computed Tomography; OLT, osteochondral lesion of the talus.
Definitions of Postoperative Rehabilitation Protocols.
Abbreviation: ROM, range of motion.
Clinical Evaluation
The following patient characteristics were collected at baseline: age, gender, weight, height, body mass index (BMI), affected side, primary/nonprimary origin of the lesion, and postoperative regimen (ie, immediate weightbearing or delayed weightbearing) as described in Table 2. By means of questionnaires, the following outcomes were collected at baseline and at the 12-month follow-up: numeric rating scale (NRS) scores for the subscales of pain during walking, pain during rest, pain during running, and pain during stair climbing; Foot and Ankle Outcome Score; and 36-Item Short Form Health Survey score. All questionnaires were sent with Electronic Data Capture (EDC) program Castor. Additionally, all patients were evaluated for complications including wound infections within 6 weeks following surgery or reoperations within 12 months after surgery.
Radiologic evaluation
Radiologic characteristics were collected from the electronic patient files. Measurements were performed by 2 independent researchers on all baseline computed tomography (CT) scans (TB, JH). The following lesion characteristics were measured at baseline and at 12-month follow-up: anteroposterior (AP) size (mm), medial-lateral (ML) size (mm), depth (mm). Based on all diameters, lesion surface (mm2) was calculated according to the formula 0.79 × AP × ML, and lesion volume (cm3) was calculated according to the ellipsoid formula. The lesion locations were collected according to the 9-grid scale. 7 Additionally, the volume of bone filling at final follow-up was measured and graded as good (67%-100%), moderate (34%-66%), or poor (0%-33%). 17 Cyst recurrence was assessed by 2 independent researchers (TB, JH) and was defined as persistence or recurrence of cysts in the treated area.
Outcome Measures
The primary outcome of this study is the comparison of the change in NRS of pain during walking, between baseline and at 12 months postoperatively between both groups. Furthermore, the proportion of patients exceeding the minimal clinically important difference (MCID) in both groups was calculated. Secondary outcomes consisted of change in the NRS subscale scores of pain during running, pain during stairclimbing, and pain during rest; 36-Item Short Form Health Survey score; Foot and Ankle Outcome Score subscales return to work and return to sport; and radiologic outcomes between both groups at 12 months.
Return to Sport and Work Outcomes
Preoperatively, data on the level (ie, amateur, competitive, or professional) and type of sports were collected. Return to sport was defined as return to any level of sports. Return to work was defined as return to their own work function with minimal adjustment of working activities.
Statistical Analysis
Matching in this study was conducted according to the propensity score–matching strategy. The following variables were used for matching: age, gender, side, lesion size (volume and surface), primary or nonprimary lesion, BMI, and pain at baseline measured with the NRS of pain during walking. The sample size calculation was based on a power of 80% with a level of significance of .05. An MCID of 2 with an SD of 1.3 on the primary outcome was used as this correlates with “much better.”14,19 This resulted in a minimum of 10 patients per treatment group in order to reach a power of 80%.
All continuous baseline characteristics are presented in mean (SD) or median and interquartile range depending on distribution of the data. Categorical characteristics are presented in absolute numbers and percentages. Normality of the data was determined based on the Shapiro-Wilkinson test and visual inspection.
For the comparison between both groups, an unpaired
For the measurement of lesion sizes, an interobserver reliability was calculated using a 2-way random interclass correlation (ICC) model. The ICC was interpreted as poor (0.40), moderate (0.40-0.75), substantial (0.75-0.90), or excellent reliability (>0.90). 22 Two researchers (TB, JH) assessed the bone filling and cyst recurrence together and consulted a third researcher (JD) in case of doubt or disagreement.
All statistical analysis were performed using R (version 4.1.0; Foundation for Statistical Computing, Vienna, Austria). 16 Validation of the analyses was performed using custom-made scripts in Python (version 3.11.8) with packages SciPy (1.11.2) and Matplotlib (version 3.7.2).18,23
Results
In total, 44 patients were eligible for this study. Fifteen patients were excluded because of incomplete baseline or follow-up data of the primary outcome. Fourteen patients were excluded because of additional procedures during surgery. Ten patients received additional ankle ligament surgery, 3 had a syndesmotic repair, and 1 underwent an open BMS. After matching, 13 patients per treatment group were included (Figure 1). Baseline characteristics are presented in Table 3 and the supplementary materials. Twenty patients had a history of ankle surgery, of which 18 patients had previous surgery on their OLT (16 arthroscopic and 2 open). Of these 18 patients, 1 had previously undergone ankle ligament reconstruction and 1 had a flexor hallucis longus release. Three patients had an osteophyte resection.

Selection procedure.
Baseline Characteristics.
Abbreviations: BMI, body mass index; F, female; L, left; M, male; R, right.
Clinical Outcomes
The mean NRS of pain during weightbearing improved from 5.2 to 3.7 (
Change in Clinical Outcomes at 12- Month Follow-up.
Abbreviations: ADL, activities of daily living; FAOS, Foot and Ankle Outcome Score; QOL, quality of life; NRS, numeric rating score.
No complications or reoperations were recorded in either group. In the immediate weightbearing group, 11 of 11 patients (100%) returned to work after a mean time of 7.3 weeks (SD: 3.7). In the delayed weightbearing group, 8 of 10 patients (80%) returned to work after a mean time of 9.8 weeks (SD: 6.8). Nine of 11 patients (81%) returned to sports after a mean time of 18.8 weeks (SD: 10.3) after immediate weightbearing. After delayed weightbearing, 9 of 10 patients (90%) returned to sport after a mean time of 19.2 weeks (SD: 12.0). Both rate and time of return to sport did not significantly differ between both groups. All return to work and return to sport outcomes are presented in the supplementary materials.
Radiologic outcomes
At 12-month follow-up, no significant differences were observed between either group in terms of cyst recurrence or lesion filling. All radiologic outcomes are presented in the supplementary materials. For lesion sizes, an ICC of 0.96 was calculated.
Discussion
The most important finding of this study is that there is no statistically significant difference in change on NRS pain during weightbearing between baseline and 12-month follow-up between immediate weightbearing and delayed weightbearing. A clinically relevant difference was observed in the proportion of patients who exceeded the MCID of 2, with a higher rate in the early weightbearing group. No other difference in patient reported outcomes, return to sport and return to work, or radiologic differences were found between both groups at the 12-month follow-up. No complications or reoperations occurred within the 1-year follow-up. These results support the feasibility of immediate postoperative weightbearing, but should be interpreted with caution because of the exploratory nature of the study and limited sample size.
Weightbearing after surgical procedures is a point of ongoing debate as early weightbearing provides an early return to normal function and provides better quality of life. However, it has been reported that the fibrin clot created as a result of the BMS needs a certain time of immobilization.9,21 On the contrary, another school of thought is that early weightbearing is needed for optimal fibrocartilage maturation. The literature regarding similar cartilage injuries in the knee has shown no adverse effects following early weightbearing, which supports the safety of early weightbearing in cartilage lesions.10,12 Additionally, noncompliance has been reported with delayed weightbearing. 21 These reasons emphasize the need for a study assessing early weightbearing (defined as immediate postoperative weightbearing).
This is the first study that describes clinical and radiologic outcomes after immediate postoperative weightbearing. In the current literature, several definitions have been used for early weightbearing. However, immediate progression to full weightbearing from the first postoperative day without bracing or splinting has not been published before. Wei et al 24 used braces and progressed to full weightbearing at 4 weeks, whereas the current study does not use any brace and allows full weightbearing immediately postoperation. Early weightbearing and avoidance of supportive plasters or braces enables patients to mobilize early and facilitates early return to normal function. Early return to normal function will improve quality of life and patient satisfaction. Findings of this study showed that there is no difference in clinical outcomes at 12 months while confirming that the benefits of early weightbearing do not negatively influence the outcomes at 12 months.
When compared to studies that start with partial weightbearing and progress to full weightbearing at 4 weeks, it can be stated that there is no difference between immediate postoperative weightbearing in terms of clinical outcomes. 24 Although no complications or reoperations were observed in this small cohort, the need for bracing should be evaluated cautiously and confirmed in future studies.
This study shows that there were no significant differences at the 12-month follow-up between the immediate weightbearing group and delayed weightbearing group on the primary outcome, NRS during weightbearing. Furthermore, the Hedges
With an early return to sport and high rates of returning to sport in this study, immediate weightbearing should be considered in daily practice. However, results on the return to sport rate need to be interpreted with caution as we do not take into account the level of returning. This should be studied more closely in order to give patients a clear view on what to expect.
Besides the equal clinical outcomes found in this study, even radiologic outcomes were similar as well after 12 months in both groups. Furthermore, there was no difference in complications or reoperations between the 2 groups. This may affirm that immediate weightbearing is safe after arthroscopic BMS in comparison to delayed weightbearing.
Strengths and Limitations
To our knowledge, this is the first study that describes the comparison between immediate postoperative weightbearing and weightbearing after 6 weeks following arthroscopic BMS. Additionally, to our knowledge, this is the first weightbearing study comparing radiologic outcomes between immediate weightbearing and delayed weightbearing. Another strength is the return to sport and return to work outcomes, which has not been analyzed in literature. Furthermore, use of matching strategy and power calculation can be considered as strengths because this improves the methodologic quality.
However, our power calculation was based on an MCID for the NRS, which is not validated for OLTs. The clinical relevance of this threshold in OLTs remains uncertain. Another limitation is that this study lacks short-term outcomes, which made it difficult to draw conclusions in terms of clinical outcomes and patients’ satisfaction after 3 and 6 months. It is expected that patients would be more satisfied if they could return earlier to normal function, but outcomes of this study do not allow for this conclusion to be drawn as it may be affected by recall bias. Additionally, although patients were matched on key clinical variables, selection bias remains a risk because of the retrospective, surgeon-determined allocation to postoperative protocol. This design limits the ability to control for unmeasured confounding. Furthermore, duration of symptoms and physical therapy treatment before surgery is not included in this study, which might influence the success of the treatment. However, this factor may be affected by recall bias as well. Despite the power calculation, only 13 patients were included in each group. This limited sample size may reduce statistical power, increasing the risk of a type II error and leading to a false negative result. When considering the power calculation for the primary outcome, a large effect size was used based on existing literature. However, this may have contributed to the inability to detect statistically significant group differences within the limited sample size. Future studies need to assess subjective outcomes such as satisfaction and quality of life in the short term to confirm the supposed advantages of immediate weightbearing. Another limitation is the risk of type I errors as a result of multiple testing. In the present study, such a correction would not affect the conclusions drawn from the results, as it was not statistically significant and its exploratory origin. However, future studies with larger sample sizes should consider correcting for multiple comparisons to ensure the robustness of findings.
The current study is conducted in a retrospective manner with a prospective database. Although matching is conducted on the most important factors, a randomized controlled trial with a noninferiority design is needed to assess the outcomes on a higher methodological level. Additionally, the effect of weightbearing on long-term radiologic outcomes is not known.
Conclusion
This study did not identify any meaningful differences in outcomes between immediate and delayed weightbearing after arthroscopic bone marrow stimulation for talar osteochondral lesions. Because of methodologic limitations and small sample size, the results should be interpreted cautiously and warrant further investigation in larger prospective studies.
Supplemental Material
sj-docx-2-fai-10.1177_10711007251348196 – Supplemental material for Immediate Postoperative Weightbearing Following Arthroscopic Bone Marrow Stimulation for Talar Osteochondral Lesions
Supplemental material, sj-docx-2-fai-10.1177_10711007251348196 for Immediate Postoperative Weightbearing Following Arthroscopic Bone Marrow Stimulation for Talar Osteochondral Lesions by Tristan M. F. Buck, Jari Dahmen, Quinten G. H. Rikken, Julian J. Hollander, Sjoerd A. S. Stufkens and Gino M. M. J. Kerkhoffs in Foot & Ankle International
Supplemental Material
sj-pdf-1-fai-10.1177_10711007251348196 – Supplemental material for Immediate Postoperative Weightbearing Following Arthroscopic Bone Marrow Stimulation for Talar Osteochondral Lesions
Supplemental material, sj-pdf-1-fai-10.1177_10711007251348196 for Immediate Postoperative Weightbearing Following Arthroscopic Bone Marrow Stimulation for Talar Osteochondral Lesions by Tristan M. F. Buck, Jari Dahmen, Quinten G. H. Rikken, Julian J. Hollander, Sjoerd A. S. Stufkens and Gino M. M. J. Kerkhoffs in Foot & Ankle International
Footnotes
Ethical Approval
Ethical approval for this study was obtained from the medical ethics committee from the University of Amsterdam with number 08/326.
Declaration of Conflicting Interests
The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. Disclosure forms for all authors are available online.
Funding
The authors received no financial support for the research, authorship, and/or publication of this article.
ORCID iDs
Supplemental Material
Supplementary material is available online with this article.
References
Supplementary Material
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