The incidence and morphological features of rheumatoid necroses (RN) in the forefoot are unknown.
Methods:
Biopsy material from 223 patients with seropositive rheumatoid arthritis (RA) was examined morphologically. The incidence and morphological features of RN in the forefoot were evaluated.
Results:
RN was found in 65% of cases, which had not been suspected clinically. It was correlated with pain in 69% of cases.
Conclusions:
Rheumatoid necrosis contributes to the development of pain and foot deformation. It can be a significant factor worsening the clinical behavior in seropositive RA patients.
ChantryDWinearlsCGMainiRNFeldmannM: Mechanism of immune complex mediated damage: induction of interleukin 1 by immune complex and synergy with interferon-Y and tumor necrosis factor-α. Eur. J. Immunol.19:189–192, 1989.
2.
FassbenderHG: Das Kranheitsbild der Rheumatoiden Arthritis als Ergebnis unterschiedlicher Pathomechanismen. Z. Rheumatol.44:33–40, 1985.
3.
FassbenderHG: Spezifische und unspezifische Strukturen entzündlich-rheumatischer Erkrankungen. Z. Rheumaforschung. 61–72, 1969.
HoriuchiYFujimotoM: Bilateral rheumatoid nodule development on the distal region of the soles: poor blood circulation and local pressure as possible causes. J. Dermatol.24:273–274, 1997.
6.
KochAEPolveriniPJLeibovichSJ: Functional heterogeneity of human rheumatoid synovial tissue macrophages. J. Rheumatol.15:1058–1063, 1987.
7.
McCachrenSSHaynesBENiebelJE: Localisation of collagenase mRNA in rheumatoid arthritis synovium by in situ hybridization histochemistry. J. Clin. Immunol.10:19–27, 1990.