Adenocarcinosarcoma in Barrett's Esophagus

Abstract

Carcinosarcoma of the esophagus is a rare tumor with both carcinomatous and sarcomatous components. Usually the mesenchymatous component is predominant, and the carcinomatous part is a squamous cell carcinoma. We report the case of an old man having a large polypoid mass in the distal third of the esophagus, arising in Barrett's esophagus. The tumor consisted of a mixture of vimentin-positive sarcoma and keratin-positive adenocarcinoma. The adenocarcinomatous cells also expressed the epithelial membrane antigen and did not express vimentin. To the best of our knowledge, it is the second case of adenocarcinosarcoma in Barrett's esophagus published in the English literature. The prognosis of this peculiar tumor is uncertain.