Eosinophilic Polyserositis Associated With Hepatic Globular Amyloidosis

Abstract

The authors report a case of 47-year-old man who had repeated episodes of eosinophilic pleural serositis and effusion associated with peripheral blood eosinophilia. He developed an epigastric mass 3 years after his initial illness. Laparotomy revealed a thickened, shrunken omentum adherent to the parietal peritoneum. Histologically, the omentum was heavily infiltrated with eosinophils. An open liver biopsy showed globular amyloidosis, a rare variant of amyloid with only 20 cases reported. Comprehensive examination of the patient ruled out parasitic, autoimmune, or neoplastic diseases. No features of hypereosinophilic syndrome or eosinophilic gastroenteritis were detected. The authors discuss this case with its unique association of these two unusual entities with special reference to the differential diagnosis of globular amyloid. Int J Surg Pathol 3(3):201-206, 1996