A 66-year-old woman affected by sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease) is described. She presented with renal and ovarian masses. Percutaneous fine-needle aspiration was performed. Histologic specimens showed numer ous histiocytes that contained lymphocytes or plasma cells in their cytoplasm. Strong reac tivity for histiocyte-associated antigens was diffusely present in these cells. She was treated with prednisone and cyclophosphamide; a partial remission was obtained. Int J Surg Pathol 2(4) :329-332, 1995
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