We describe the clinicopathologic and cytogenetic findings of an unusual dedifferentiated chondrosarcoma with a rhabdomyosarcomatous component in a case report and review the relevance of these findings with respect to seven previously reported cases. Cytogenetic studies of dedifferentiated chondrosarcoma are limited to 2 previously described cases, both with dedifferentiated components distinct from this case. In this study, cytogenetic analysis of 3 separate specimens, biopsy with chondrosarcoma, definitive surgical, and lung metastasis with rhabdomyosarcomatous component, revealed clonal karyotypic aberrations in each. A structural abnormality involving the short arm of chromosome 17 and extra copies of chromosomes 5, 7, 12, and 20 were common to all three specimens. These findings reveal multiple shared chromosomal anomalies between the primary chondrosarcoma and the dedifferentiated components, which suggests a clonal evolution. Int J Surg Pathol 2(4):319-328, 1995
Dahlin DC, Beabout JWDedifferentiation of low-grade chondrosarcomas. Cancer28:461-466, 1971
2.
Zalupski MM, Ensley JF, Ryan J., Seliaggi S., Baker LH, Wolman SRA common cytogenetic abnormality and DNA content alterations in dedifferentiated chondrosarcoma. Cancer66:1176-1182, 1990
3.
Astorini RN, Tesluk H.Dedifferentiated chondrosarcoma with a rhabdomyosarcomatous component . Human Pathol16:318-20, 1985
4.
Johnson S., Tetu B., Ayala AG, Chawla SPChondrosarcoma with additional mesenchymal component (dedifferentiated chondrosarcoma). I. A clinico-pathological study of 26 cases. Cancer58:278-286, 1986
Nietzabitowski A., Edel G., Roessner A., Grundmann E.Rhabdomyosarcomatous component in dedifferentiated chondrosarcoma. Pathol Res Pract182:275-279, 1987
7.
Sathaphatayavongs B., Sirikulchayanonta V., Chuen-Im V.Roentgenographic findings in malignant mesenchymoma of bone. J Med Assoc Thailand63:678-684, 1980
8.
Scheele PM, Von Kuster LC, Krivchenia II G.Primary malignant mesenchymoma of bone. Arch Pathol Lab Med114:614-617, 1990
9.
Hsu SM, Raine L., Fanger H.Use of the avidinbiotinperoxidase complex (ABC) in immunoperoxidase technique: A comparison between ABC and unlabelled antibody (PA) procedure . J Histochem Cytochem29:577, 1981
10.
Stefanini M. , De Martino C, Zamboni L.Fixation of ejaculated spermatozoa for electron microscopy. Nature216:173-174, 1967
11.
Bridge JA, Sreekantaiah C., Mouron B., Neff JR, Sandberg AAClonal chromosomal abnormalities in desmoid tumors. Implication for histopathogenesis. Cancer69:430-436, 1992
12.
Mitelman F.The chromosomes of fifty primary Rous rat sarcomas . Hereditas69:155-162, 1971
13.
Anastasi J.Interphase cytogenetic analysis in the diagnosis and study of neoplastic disorders. Am J Clin Pathol95(Suppl 1):22-28, 1991
14.
Weber-Matthiesen K., Winkeman M., Muller-Hermelink A., Schlegelberger B., Grote W.Simultaneous fluorescence immunophenotyping and interphase cytogenetics: A contribution to the characterization of tumor cells. J Histochem Cytochem40(2):171-175, 1992
15.
Ghadially FNDiagnostic electron microscopy of tumors. Butterworths , London, 1985
16.
Henderson DW , Papadimitriou JMUltrastructural appearance of tumors: A diagnostic atlas. Churchill Livingstone, New York, 1982
Robb JAChondrosarcoma of bone with "dedifferentiation." Letter. Hum Pathol13: 964, 1982
19.
Rywlin AMChondrosarcoma of bone with "dedifferentiation." Letter. Hum Pathol13:963-964, 1982
20.
Tétu B., Ordoñez NG, Ayala AG, Mackay B.Chondrosarcoma with additional mesenchymal component (Dedifferentiated chondrosarcoma). II. An immunohistochemical and electron microscopic study . Cancer58:287-298, 1986
21.
Stout APMesenchymoma, the mixed tumor of mesenchymal derivates. Ann Surg127:278-290, 1948
22.
Stout APTumors of the soft tissues. Atlas of tumor pathology, fascicle 5. Armed Forces Institute of Pathology, Washington , 1953
23.
Bridge JA, Sanger WG, Neff JRTranslocations involving chromosomes 2 and 13 in benign and malignant cartilaginous neoplasms. Cancer Genet Cytogenet38:83-88, 1989
24.
Bridge JA, Neff JRMalignant cartilage tumors. In Rennie WRJ , (ed): Current opinion in orthopaedics. Current Science, Philadelphia, pp. 796-800, 1991
25.
Fletcher JA, Lipinski KK, Weidner N., Morton CCComplex cytogenetic aberrations in a well-differentiated chondrosarcoma . Cancer Genet Cytogenet41:115-121, 1989
26.
Hinrichs SH, Jaramillo MA, Gumerlock PH, Gardner MB, Lewis JP, Freeman AEMyxoid chondrosarcoma with a translocation involving chromosomes 9 and 22 . Cancer Genet Cytogenet14:219-226, 1985
27.
Hirabayashi Y., Yoshida MA, Ikeuchi T., Ishida T., Kojima T., Higaki S., Machinami R., Tonomura A.Chromosome rearrangements at 12q13 in two cases of chondrosarcomas. Cancer Genet Cytogenet60:35-40, 1992
28.
Mandahl N., Heim S., Arheden K., Rydholm A., Willén H., Mitelman F.Chromosomal rearrangements in chondromatous tumors. Cancer65:242-248, 1990
29.
Turc-Carel C., Lizard-Nacol S., Justrabo E., Favrot M., Philip T., Tabone E.Consistent chromosomal translocation in alveolar rhabdomyosarcoma. Cancer Genet Cytogenet19:361-362, 1978
30.
Bridge JA, Bhatia PS, Anderson JR, Neff JRBiological and clinical significance of cytogenetic abnormalities in benign and malignant cartilaginous lesions. Cancer Genet Cytogenet69:79-90, 1993
Becher R., Wake N., Gibas Z., Ochi H., Sandberg AAChromosome changes in soft tissue sarcomas. J Natl Cancer Inst72:823-831, 1984
33.
Douglass EC , Valentine M., Etcubanas E., Parham D., Webber BL, Houghton PJ, Green AAA specific chromosomal abnormality in rhabdomyosarcoma . Cytogenet Cell Genet45:148-155, 1987
34.
Engel R., Ritterback J., Schwabe D., Lampert F.Chromosome translocation (2:13) (q37;q37;q14) in a disseminated alveolar rhabdomyosarcoma . Eur J Pediatr148:69-71, 1988
35.
Hayashi Y., Inaba T., Hanada R., Yamamioto K.Translocation 2;8 in a congenital rhabdomyosarcoma. Cancer Genet Cytogenet30:343-345, 1988
36.
Lai JL, Savary JB, Deminatti M., Demaille MC, Baranzelli MCTranslocation (2;13) (q37;q14) in rhabdomyosarcoma: A new case. Cancer Genet Cytogenet25:371-372, 1987
37.
Lizard-Nacol S., Mugneret F., Volk C., Turc-Carel C., Favrot M., Philip T.Translocation (2;13)(q37;q14) in alveolar rhabdomyosarcoma: A new case. Cancer Genet Cytogenet24:373-374, 1987
38.
Olegard C., Mandahl N., Heim S., Willen H., Leifsson B., Mitelman F.Embryonal rhabdomyosarcoma with 100 chromosomes but no structural aberrations . Cancer Genet Cytogenet60:198-201, 1992
39.
Pearson Adj , Reid MM, Davidson EV, Bown N., Malcolm AJ, Craft AWCytogenetic investigations of solid tumours of children. Arch Dis Child63:1012-1015, 1988
40.
Potluri VR, Gilbert F.A cytogenetic study of embryonal rhabdomyosarcoma. Genet Cytogenet14:169-173, 1985
41.
Rowe D., Gerrard M., Gibbons B., Malpas JSTwo further cases of t(2;13) in alveolar rhabdomyosarcoma indicating a review of the published chromosome breakpoints. Br J Cancer56:379-380, 1987
42.
Trent J., Casper J., Meltzer P., Thompson F., Fogh J.Nonrandom chromosome alterations in rhabdomyosarcoma. Cancer Genet Cytogenet16: 189-197, 1985
43.
Turc-Carel C., Dal Cin P, Rao U, Karakousis C, Sandberg AA. Recurrent breakpoints at 9q31 and 22q12.2 in extraskeletal myxoid chondrosarcoma . Cancer Genet Cytogenet30:145-150, 1988
44.
Wang-Wuu S. , Soukup S., Bailard E., Gotwals B., Lampkin B.Chromosomal analysis of sixteen human rhabdomyosarcomas . Cancer Res48:983-987, 1988
45.
Whang-Peng J., Triche TJ, Knutsen T., Miser J., Kao-Shan S., Tsai S., Israel MACytogenetic characterization of selected small round-cell tumors of childhood. Cancer Genet Cytogenet21:185-208, 1986
46.
Sanerkin NG , Woods CGFibrosarcomata and malignant fibrous histiocytomata arising in relation to enchondromata. J Bone Joint Surg61B:366-372, 1979
47.
McCarthy EF , Dorfman HDChondrosarcoma of bone with dedifferentiation: A study of eighteen cases. Hum Pathol13:36-40, 1982
48.
Schulz A.Letters to the case: Rhabdomyosarcomatous component in differentiated chondrosarcoma . Pathol Res Pract192-282, 1987
