Atypical meningiomas comprise an intermediate category of meningeal neoplasmas with some microscopic features of aggressivity and a capacity for recurrence. We present a clin ical, morphologic, and cytogenetic study of 15 meningiomas. Morphologic and cytogenetic analysis suggested the existence of morphologically typical meningiomas with normal karyotype or monosomy 22 and morphologically atypical meningiomas, with increasing chromosomal abnormalities (complex karyotype) between these two types. Present results suggest the existence of a third type of morphologically typical meningioma that lacks a phenotypical aggressivity but has a complex karyotype. These genotypical characteristics may be related to the aggressivity of these neoplasms. Int J Surg Pathol 2(4):301-310, 1995
Simpson D.The recurrence of intracranial meningiomas after surgical treatment . J Neurol Neurosurg Psychiatr20:22-39, 1957
2.
Inoue H., Tamura H., Koizumi H., Nakamura M., Naganuma H., Ohye C.Clinical pathology of malignant meningioma. Acta Neurochir (Wien)73:179-191, 1984
3.
Mirimanoff R. , Dosoretz A., Linggood R, Oseman R, Martuza R. Meningiomas: Analysis of recurrence and progression following neurosurgical resection . J Neurosurg62:18-24, 1985
4.
Cushing H., Eisenhardt C.Meningiomas. Their classification, regional behavior, life history and surgical end results. Charles C Thomas, Springfield, Illinois, 1938
5.
Russell D., Rubinstein L.In Pathology of tumors of the nervous system, 5th ed. Williams & Wilkins, Baltimore, pp. 449-532, 1989
6.
Kepes J.Review of the WHO's new proposed classification of brain tumors. XIth International Congress of Neuropathology, Kyoto, Japan, 1990
7.
Rubinstein L. In Tumors of the central nervous system. AFIP, Washington, pp. 169-190, 1972
8.
Kepes J. In Meningiomas: Biology, pathology and differential diagnosis. Masson Publishing, pp. 206, 1982
9.
Jellinger K. , Slowik K.Histological subtypes and prognostic problems in meningiomas. J Neurol208:279-298, 1975
10.
Kepes J.Presidential address: The histopathology of meningiomas. A reflection of origins and expected behavior?J Neuropathol Exp Neurol45:95-107, 1986
11.
Scheithauer B.Tumors of the meninges: Proposed modifications of the World Health Organization classification. Acta Neuropathol80:343-354, 1990
12.
Maier H., Ofner D., Hittmair A., Kitz A., Budka H.Classic, atypical and anplastic meningioma: Three histopathological subtypes of clinical relevance. J Neurol Surg77:616-623, 1992
13.
Kleihues P., Burger PC, Scheithauer BWHistological typing of tumours of the central nervous system. World Health Organization International Histological Classification of Tumours. Springer-Verlag, Berlin, 1993
14.
Mark J.Chromosomal aberrations and their relation to malignancy in meningiomas: A meningioma with ring chromosomes. Acta Pathol Microbiol Scand (Sect A) 79:193-200, 1971
15.
Yamada K., Kendo T., Yoshioka M., Dami H.Cytogenetic studies in twenty human brain tumors: Association of no. 22 chromosome abnormalities with tumors of the brain. Cancer Genet Cytogenet2:293-307, 1980
16.
Zang KDCytological and cytogenetical studies on human meningiomas. Cancer Genet Cytogenet6:249-274, 1982
17.
Al Saadi A, Latimer F., Madercia M., Robbins T.Cytogenetic studies of human brain tumors and their clinical significance. II. Meningioma. Cancer Genet Cytogenet26:127-141, 1987
18.
Maltby EL, Ironside JW, Battersby Rde.Cytogenetic studies in 50 meningiomas. Cancer Genet Cytogenet31:199-210, 1988
19.
Rey JA, Bello MJ, de Campos JM, Kusak E., Moreno S.Chromosomal involvement secondary to -22 in human meningiomas. Cancer Genet Cytogenet33:275-290, 1988
20.
Casalone R. , Simi P., Granate R., Tunelli E., Giu A., Butti G., Solero CLCorrelation between cytogenetic and histopathological findings in 65 human meningiomas. Cancer Genet Cytogenet45:237-241, 1990
21.
Casartelli C., Rogatto SR, Neto JBKaryotype evolution of human meningioma progression through malignancy. Cancer Genet Cytogenet40:33-45, 1989
22.
López-Ginés C., Piquer J., Cerdá-Nicolás M., Barcia-Salorio J., Barcia-Mariño C.Meningiomas: Karyotypes and histological patterns. Clin Neuropathol8:130-133, 1989
23.
Meloni A., Morgan R., Bridge J., Erling MA, Lewin RJ, Sandberg AACytogenetic findings in typical and atypical meningioma. Cancer Genet Cytogenet51:35-39, 1991
24.
Vagner-Capodano A., Grisoli F., Gambarelli D., Sedan R., Pellet W., De Victor B.Correlation between cytogenetic and histopathological findings in 75 human meningiomas . Neurosurgery32:892-900, 1993
25.
Hsu H., Raine L., Fange H.Use of avidin-biotin-peroxidase (ABC) in immunoperoxidase technique: A comparison betwee ABC and unlabelled antibody (PAP) procedures. J Histochem Cytochem29: 557-580, 1981
26.
Seabright M.A rapid banding technique for human chromosomes . Lancet2:971-972, 1971
27.
Iscn. In An International System for Human Cytogenetic Nomenclature, Harnden DG, Klinger HP (eds); published in collaboration with Cytogenetic Cell Genet ( Karger, Basel) 1985; also in Birth Defects: Original Article Series, Vol. 21, No. 1 (March of Dimes Birth Defects Foundation, New York), 1985
28.
Skullerud K. , Löken A.The prognosis of meningiomas. Acta Neuropathol (Berl)29:337-344, 1974
29.
Jellinger K.Biologic behavior of meningiomas. In Fields WS (ed): Primary brain tumors: A review of histologic classification . Springer Verlag, New York, pp. 231-279, 1975
30.
Yamashita J. , Handa H., Iwaki K., Abe M.Recurrence of intracranial meningiomas, with special reference to radiotherapy. Surg Neurol14:33-40, 1980
McLean C., Jolley D., Cukier E, Giles G, Conzales M. Atypical and malignant meningiomas: Importance of micronecrosis as a prognostic indicator. Histopathology23:349-353, 1993
33.
Burger P., Vogel S.In Surgical pathology of the nervous system and its coverings. John Wiley & Sons, New York, pp 73-97, 1976
34.
Baker D., Meurer H., Gullotta F.Recurring intracranial meningioma of some factors predisposing for tumor recurrence . J Neurosurg Sci29:11-17, 1985
35.
Jääskelainen J., Haltia M., Laasonen E., Wahlstrom T., Valtonen S.The growth of intracranial meningiomas and its relation to histology: An analysis of 43 patients. Surg Neurol24:165-172, 1985
36.
de la Monte S., Flickinger J., Linggood R.Histopathologic features predicting recurrence of meningiomas following subtotal resection. Am J Surg Pathol10:836-843, 1986
37.
Benedict EF , Poster IH, Brown CD, Florentin RACytogenetic diagnosis of malignancy in recurrent meningioma. Lancet1:971-973, 1970
38.
Mark J.Karyotype patterns in human meningiomas: A comparison between studies with G- and Q-banding techniques. Hereditas75:213-220, 1971
39.
Zankl H., Singer H., Zang KDCytological and cytogenetical studies on brain tumors. II. Hyperdiploidy, a rare event in human meningiomas. Hum Genet11:253-257, 1971
