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Abstract

The expression of monoclonal antibody p53 (PAb 1801) was studied by immunohisto chemistry in 16 endocervical and 28 endometrial adenocarcinomas. Eight endocervical and 17 endometrial carcinomas were p53 positive. The nuclear staining varied from focal to diffuse strong positivity. Follow-up information was obtained in 24 patients with endometrial tumors and in 10 patients with endocervical tumors. Of the 2 patients with endocervical tumors who died with disease, 1 showed strong p53 positivity while the other case was negative. Of the 8 patients with endometrial carcinoma who died, 6 showed positivity for p53 and 2 were negative. A significant correlation in intensity of staining was observed between well- and poorly differentiated endometrial adenocarcinomas (P < .001); however, this correlation was not observed in endocervical carcinomas. Int J Surg Pathol 2(4):269-274, 1995

Keywords

immunohistochemistry endocervical and endometrial adenocarcinomas.

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p53 Expression in Endocervical and Endometrial Adenocarcinomas

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